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A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease

A technology for hyperphosphatemia and anemia, which is used in drug combinations, pharmaceutical formulations, organic active ingredients, etc.

Active Publication Date: 2009-12-30
GUANGDONG BANGMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Equally, in International Publication No. WO94 / 27621 communique, record the method that binds iron ion by means of the polymkeric substance that contains amino group, if the polystyrenes of amino group and acrylic resin are administered as they are, the above-mentioned side effects (iron deficiency) also occur. anemia) the possibility of

Method used

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  • A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease
  • A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease
  • A medicine for treating hyperphosphatemia disease and iron deficiency anemia disease

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preparation example Construction

[0013] The preparation method of the above-mentioned medicine for treating hyperphosphatemia and iron deficiency anemia, the steps are as follows:

[0014] Take polystyrene sulfonate resin and acidify with hydrochloric acid to obtain polystyrene sulfonic acid resin, then soak or elute with water-soluble ferrous salt solution, wash with water until the pH value is neutral, and then remove the excess ferrous ions that have not been exchanged Until it is washed, the ferrous polystyrene sulfonate resin is taken out, dried and pulverized into powder, and the weight of ferrous iron in the obtained ferrous polystyrene sulfonate resin powder is 3.8%-5.1%.

[0015] Wherein, the polystyrene sulfonate resin can be selected from sodium polystyrene sulfonate resin, calcium polystyrene sulfonate resin, potassium polystyrene sulfonate resin or magnesium polystyrene sulfonate resin, considering industrial production In terms of production cost, sodium polystyrene sulfonate resin or calcium po...

Embodiment 1

[0064] Embodiment 1. A kind of medicine for the treatment of hyperphosphatemia and iron-deficiency anemia, the active ingredient of medicine is ferrous polystyrene sulfonate resin, average molecular weight 3000-10000, and the polymerization unit structural formula is as follows:

[0065]

[0066] The preparation method is as follows:

[0067] Get 50 grams of sodium polystyrene sulfonate resin, acidify with hydrochloric acid to obtain polystyrene sulfonic acid resin, soak with 2000 milliliters of 8% ferrous acetate, keep the temperature at 50 ° C for 8 hours, wash with deionized water until The pH is close to neutral, continue to wash until the excess ferrous ions are washed away. Take out the ferrous polystyrene sulfonate resin, dry it, and pulverize it. The powdered ferrous polystyrene sulfonate resin was obtained, and the weight of ferrous iron in the ferrous polystyrene sulfonate resin was detected to be 4.7%. The ferrous polystyrene sulfonate resin powder can be used ...

Embodiment 2

[0068] Embodiment 2. A kind of medicine for the treatment of hyperphosphatemia and iron deficiency anemia, the active ingredient of medicine is ferrous polystyrene sulfonate resin, and the weight percent of ferrous polystyrene sulfonate resin in medicine is 95%wt, the preparation method is as follows:

[0069] Get 50 grams of calcium polystyrene sulfonate resin, acidify with hydrochloric acid to obtain polystyrene sulfonic acid resin, soak with 2000 ml of 15% ferrous gluconate, keep the temperature at 20°C for 20 hours, and wash with deionized water Until the pH is close to neutral, continue washing until the excess ferrous ions are washed away. Take out the ferrous polystyrene sulfonate resin, dry it, and pulverize it. The powdered ferrous polystyrene sulfonate resin was obtained, and the weight of ferrous iron in the ferrous polystyrene sulfonate resin was detected to be 3.82%. Take ferrous polystyrene sulfonate resin powder, prepare granules according to the amount of con...

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Abstract

The invention relates to medicine treating hyperphospheremia and iron deficiency anemia. Polystyrene sulfoacid ferrous iron resin is used as the effective component of the medicine, the medicine is produced by either adding medical auxiliary material or not, administration is performed by passing through gastrointestinal tract, the effective component and phosphate in the alimentary tract of a patient are combined together to be an insoluble substance which is excreted to the outside of the body through the alimentary tract, thereby the phosphate in the body of a chronic renal failure patient is reduced, and the aim of treating the hyperphospheremia is achieved. Simultaneously, residual ferrous ions of the polystyrene sulfoacid ferrous iron resin are dissociated, and are absorbed by the human body to supplement the ferrous ions in the body, thereby achieving the aim of treating the iron deficiency anemia of the chronic renal failure patient. The medicine can also be used for the treatment of the hyperphospheremia of the chronic renal failure patient and used as the preventive agent of the iron deficiency anemia.

Description

technical field [0001] The invention relates to a medicine for treating hyperphosphatemia and iron deficiency anemia. Background technique [0002] Patients with chronic renal insufficiency usually have to receive regular dialysis treatment for a long period of time, but they often have elevated plasma phosphorus concentrations (above 4.5 mg / dL), resulting in so-called hyperphosphatemia. For hyperphosphatemia, no direct treatment for the cause has been developed, so dietary therapy is generally used to reduce the absorption of phosphorus, or as a symptomatic treatment, oral administration can absorb phosphate ions in the organs of the digestive tract for hyperphosphatemia method of treatment. In general, aluminum hydroxide gel or precipitated calcium carbonate, lanthanum carbonate hydrate and sevelamer can be used as therapeutic agents for hyperphosphatemia. [0003] In the pathological state of chronic renal insufficiency showing hyperphosphatemia, iron deficiency anemia ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/795A61K9/14A61K9/16A61K9/20A61K9/48A61P3/02A61P13/12
Inventor 刘钢
Owner GUANGDONG BANGMIN PHARMA
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