Process for preparing porous biological ceramics supporting frame

A technology of bioceramics and pore diameter, which is applied in medical science, prosthesis, etc., can solve the problems of residue preparation process, complexity, and large connection diameter of porous bioceramic scaffolds, and achieve high sphericity, small equipment volume, The effect of high powder utilization rate

Active Publication Date: 2007-08-08
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In order to overcome the disadvantages of the prior art, such as the small ratio of the connection diameter in the hole of the porous ceramic support to the diameter of the ball hole, the presence of residues, and the complex preparatio

Method used

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  • Process for preparing porous biological ceramics supporting frame

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of a porous bioceramic scaffold with a diameter larger than 100 μm.

[0029] This porous bioceramic scaffold can ensure that osteoclasts with a diameter of 100 μm pass through each pore. Referring to Table 1, select a sieve with 24-26 meshes to screen out the spherical particle structure scaffold with a diameter of 710-800 μm, and the pore diameter of the scaffold is between 110-586 μm. The specific process is as follows:

[0030] Weigh 30g of PVA aqueous solution with a mass concentration of 5% as a binder, mix it with 70g of tricalcium phosphate bioceramic powder, and use the Mini-250 extrusion spheronizer produced by Shenzhen Xinyite Pharmaceutical Equipment Co., Ltd. The ceramic powder is subjected to orifice plate extrusion, cutting and spheronizing processes to produce tricalcium phosphate spherical particles, and the tricalcium phosphate spherical particles with a diameter of 710-800 μm are screened out with a 24-26 mesh sieve and dried fo...

Embodiment 2

[0033] Example 2: Preparation of a porous bioceramic scaffold with a diameter less than 400 μm.

[0034] This porous bioceramic scaffold has high mechanical properties and osseointegration performance. Studies have shown that when the pore size is greater than 400 μm, the bonding force of bone decreases. Referring to Table 1, select a 35-40 mesh sieve to screen out a spherical particle structure scaffold with a diameter of 450-500 μm, and the pore size of the scaffold is between 70-366 μm. The specific process is as follows:

[0035]Weigh 20g of PVA aqueous solution with a mass concentration of 3% as a binder, mix it with 80g of calcium-deficient hydroxyapatite bioceramic powder, and use the Mini-250 extrusion spheronization produced by Shenzhen Xinyite Pharmaceutical Equipment Co., Ltd. The granulator implements orifice plate extrusion, cutting and spheronizing process on the ceramic powder to produce calcium-deficient hydroxyapatite particles, and uses a 35-40 mesh sieve t...

Embodiment 3

[0039] Example 3: Preparation of a porous bioceramic scaffold with a pore diameter of less than 800 μm.

[0040] This porous bioceramic scaffold has better blood circulation ability, which is beneficial to realize bone repair in parts far away from the heart where blood circulation is weak. Although this porous bioceramic scaffold is not optimal in terms of bone bonding at the initial stage of implantation in the human body, as the osteoblasts grow on the scaffold, the pore diameter gradually becomes smaller, and the bone bonding will increase. be strengthened. Referring to Table 1, select a 18-20 mesh sieve to screen out the particle structure scaffolds with a diameter of 900-1000 μm, and a pore size of 139-732 μm. The specific process is as follows:

[0041] Weigh 50g of PVA aqueous solution with a mass concentration of 4% as a binder, mix it with 50g of alumina bioceramic powder evenly, and use the Mini-250 extrusion spheronizer produced by Shenzhen Xinyite Pharmaceutical...

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Abstract

The invention relates to a method for preparing the porous biological ceramic support, used to repair the ill or hurt skeleton. The invention comprises that using polyvinyl alcohol water solution as adhesive to be mixed with biological ceramic powders, to be compressed via porous plate, cut and rolled, to obtain spherical particles, to be screened and dried; using the polyvinyl alcohol water solution as adhesive to be mixed with said spherical particles to be molded in mould, and sintered in sintering furnace. The invention uses the extruding rolling particle making method to prepare the biological ceramic spherical particles, with uniform diameter, while said particles are directly stacked into porous structure; therefore, the final support has non sealed porous structure, while the connecting diameter and the aperture is rationed higher than 1.0. And the polyvinyl alcohol is carbon hydrogen oxygen polymer which can be burnt out at high temperature, to avoid left material.

Description

technical field [0001] The invention relates to a preparation method of a porous bioceramic support. Background technique [0002] For bone tissue with lesion or damage, natural bone such as body bone, allogeneic bone, heterogeneous bone or artificial bone can be used for repair. However, the homologous bone repair method belongs to the treatment method of "removing the east wall to make up the west wall", which will cause secondary trauma to the patient, and the number of bone repairs is also greatly limited. Allograft bone and xenograft bone have the potential risk of disease transmission. Artificial bone is designable, can be produced on demand, and is easy to standardize, so as to solve various problems of bone repair in a long-lasting and effective manner. Artificial bone scaffolds are usually made of biocompatible metals, polymers or ceramics. Among them, metal stents have high mechanical properties, but free metal ions are potentially dangerous; polymer stents have...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/12
Inventor 曾庆丰刘永胜多桂英张立同闫秀天
Owner 西安点云生物科技有限公司
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