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Method for preparing novel medicine capsule and plant capsule

A technology of capsules and plants, applied in the field of polymer chemistry, can solve problems such as easy to contain aldehydes, easy to break, and become brittle, and achieve the effects of improving production efficiency, low moisture content, and saving production costs

Inactive Publication Date: 2007-08-29
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in use, gelatin capsules have some disadvantages and deficiencies, such as easy drug cross-linking containing aldehydes, reducing sugar-based compounds and vitamin C, which not only affects the disintegration of the capsule shell but also affects drug stability; long-term storage in low humidity Becomes brittle in the environment, breaks easily when handled, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Under stirring conditions, heat 85.1 parts (mass) of deionized water to 70-75°C, add 0.2 parts of gellan gum, stir to dissolve, then add 0.2 parts of sodium chloride; slowly add 14.5 parts of Hydroxypropyl methylcellulose, lower the temperature to 45°C, keep warm and let it stand for 4-10 hours to remove foam; immerse the needle with a temperature of 25°C in the dipping glue solution, stay for 10 seconds, slowly pull it out, and put it at 55°C Drying under the sun; the dried capsule-shaped film is demolded from the needle and trimmed to form the capsule shell.

Embodiment 2

[0023] Under stirring conditions, heat 82 parts of deionized water to 70-75°C, add 0.6 parts of gellan gum, stir to dissolve, then add 0.04 parts of calcium chloride: slowly add 18 parts of hydroxypropyl Methyl cellulose, lower the temperature to 45°C; dip the needle at 25°C into the dipping glue solution, then pull it out slowly, and dry it at 55°C; remove the dried capsule film from the needle for trimming, Serve as a capsule shell.

Embodiment 3

[0025] Under stirring conditions, heat 74 parts (mass) of deionized water to 70-75°C, add 0.6 parts of gellan gum, stir to dissolve, then add 0.05 parts of calcium chloride; under stirring conditions, slowly add 25 parts Hydroxypropyl methylcellulose, cooling down; immerse the needle at 25°C in the dipping glue solution, then slowly pull it out, and dry it at 55°C; remove the dried capsule film from the needle for trimming, Serve as a capsule shell.

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Abstract

The present invention relates to a preparation method of new-type medicine capsule-plant capsule. It is characterized by that it adopts conventional capsule production method, uses the gelatin capsule production machine and utilizes natural plant cellulose derivative-cellulose ether as raw material to produce the invented plant capsule.

Description

technical field [0001] The invention relates to a preparation method of herbal medicine capsules, in particular to a method for preparing herbal medicine capsules by adopting a traditional glue-dipping process and using natural plant cellulose derivatives as raw materials, which belongs to the technical field of macromolecule chemistry. Background technique [0002] In 1846, Lehury was the first to obtain a patent for a two-section hard capsule. These capsules are made from starch or tapioca flour, sweetened with sucrose and colored with "fish silver". [0003] Lehury also describes the use of different materials and mixtures including gelatin and the like. Gelatin is produced by hydrolyzing the bones and skins of cattle, pigs and other animals. It belongs to protein substances and is widely used in the food industry. It is easily soluble in body fluids at body temperature and is a good film-forming material. Gelatin has been used to make capsules for a long time, and its ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61J3/07
Inventor 邵自强王飞俊杨斐霏
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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