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Method for preparing malic acid containing unit functional polyester by biological catalysis in organic medium

A biocatalysis and malic acid technology, applied in the direction of fermentation, can solve the problems such as the difficulty of carrying out the polymerization reaction, the low molecular weight of the polyester product, and the limitation of research and application. Effect

Inactive Publication Date: 2011-05-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular weight of the polymalic acid prepared by the microbial synthesis method is relatively high, and the product is relatively pure; however, the yield of this method is low, the product separation is difficult, the cost is high, and the product structure is single. At present, only β-polymalic acid can be synthesized. It is difficult to obtain functional polyesters containing malic acid units with other structures, which greatly limits its research and application
[0004] When using enzyme-catalyzed direct condensation polymerization to prepare malic acid-containing functional polyester, if a solvent-free reaction system is selected, although the reaction process still has the characteristics of mild reaction conditions, simple reaction process, controllability, and environmental friendliness, but due to The viscosity of the reaction system is high, and the polymerization reaction is difficult to proceed, resulting in a low molecular weight of the obtained polyester product
Low molecular weight polyesters limit their use in biomedicine

Method used

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  • Method for preparing malic acid containing unit functional polyester by biological catalysis in organic medium
  • Method for preparing malic acid containing unit functional polyester by biological catalysis in organic medium
  • Method for preparing malic acid containing unit functional polyester by biological catalysis in organic medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add butanediol, adipic acid and malic acid in a 100mL round-bottomed flask according to the molar ratio of 15:13:2 (the ratio of carboxyl and hydroxyl groups is 16:15), and the total amount of octane and monomers is 3: Add in a mass ratio of 1, add lipase from Candida antarctica at 1000U / gram of monomer, place in an oil bath at 70°C, and magnetically stir at 200rpm, add molecular sieves, react for 48 hours, add chloroform to dissolve the product, and filter The lipase was removed, and the product solution was vacuum spin-dried to obtain a polymer with a molecular weight of 32,000.

Embodiment 2

[0026] Add butanediol, adipic acid, and malic acid into a 100mL round-bottomed flask in a molar ratio of 15:7.5:7.5 (the ratio of carboxyl and hydroxyl groups is 5:4), and the ratio of n-hexane and the total amount of monomers is 3:1. Add in the mass ratio of 1500U / gram of monomer and add lipase from Candida antarctica, put it in an oil bath at 80°C, with a magnetic stirring speed of 200rpm, add molecular sieves, react for 96 hours, add chloroform to dissolve the product, and filter to remove Lipase, the product solution was vacuum spin-dried to obtain a polymer with a molecular weight of 14,500.

Embodiment 3

[0028] Add ethylene glycol, adipic acid, and malic acid into a 100mL round-bottomed flask in a molar ratio of 15:13:2 (the ratio of carboxyl and hydroxyl groups is 16:15), and the total amount of cyclohexane and monomers is 3: Add in a mass ratio of 1, add lipase from Candida antarctica at 4000U / gram of monomer, place it in an oil bath at 40°C, magnetically stir at 200rpm, add molecular sieves, react for 48 hours, add chloroform to dissolve the product, and filter The lipase was removed, and the product solution was vacuum-rotated to obtain a polymer with a molecular weight of 5,700.

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Abstract

The invention discloses a catalyzing method to prepare functional polyester with malic acid unit in the organic dielectric, which is characterized by the following: adopting dihydroxy alcohol and malic acid as monomer and organic solvent as reacting dielectric; condensing dihydroxy alcohol and malic acid through lipase directly; making the functional polyester with malic acid unit; fitting for leading dibasic acid in the monomer system to adjust the composition and structure of polymer chain; changing kinds of properties of the product within large scale.

Description

technical field [0001] The invention belongs to the fields of biocatalytic synthesis and polymer chemistry, and in particular relates to a method for preparing functional polyester containing malic acid units through biocatalytic direct condensation polymerization. Background technique [0002] Functional polyester containing malic acid units has excellent biocompatibility, modifiability and biodegradability, and its degradation products are harmless to human body. The composition and structure of the polymer can be adjusted by adjusting the ratio of different structural units constituting the macromolecular chain of the polymer, thereby adjusting its physical and chemical properties. Studies have shown that functional polyesters containing malic acid units have broad application prospects in the fields of medicine, environmental protection, new materials, and bioengineering. Surgical sutures, green macromolecular surfactants, coating materials for drugs, etc. [0003] At ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/16C08G63/82C12P7/62
Inventor 李光吉姚大虎宗敏华
Owner SOUTH CHINA UNIV OF TECH