Extractive of persimmon leaves ethyl acetate used for prevention and/or treatment of glycolipid metabolism related diseases

A persimmon leaf ethyl acetate, glucose and lipid metabolism technology, applied to metabolic diseases, nervous system diseases, plant/algae/fungus/moss components, etc., can solve problems such as insulin deficiency, diabetes, and reduced insulin work efficiency

Active Publication Date: 2007-10-03
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] 2) Relative lack of insulin: In some patients, the level of insulin does not decrease, but the effect of insulin is greatly reduced, that is, the efficiency of insulin work is reduced. Although there is a "golden key", but the effect is not great, it can also cause diabetes, which belongs to type 2 diabetes
This type of diabetes can be treated with oral drugs first to improve the working efficiency of insulin, but about 50% of patients with type 2 diabetes will gradually have poor oral drug therapy and finally have to accept insulin therapy

Method used

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  • Extractive of persimmon leaves ethyl acetate used for prevention and/or treatment of glycolipid metabolism related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Effect of Naoxinqing on blood sugar and blood lipids of diabetic model mice

[0034]Drugs and reagents: Naoxinqing (persimmon leaf ethyl acetate extract, NXQ); Co., Ltd.); Total Cholesterol, Triglyceride, High Density Lipoprotein Cholesterol Determination Kit; Streptozotocin (STZ), product of Sigma Company of the United States; Xiaokean Capsule, product of Tonghua Baishan Pharmaceutical Co., Ltd.

[0035] Blood glucose was measured by Advantage electronic induction blood glucose meter and supporting paper strips (product of Swiss Roche Company).

[0036] The experimental object is a clean-grade Kunming male mouse with a body weight of 22-25 g provided by the Provincial Experimental Animal Center of Southern Medical University.

[0037] a) Effects on blood sugar and blood lipids in streptozotocin (STZ) diabetic model mice

[0038] Eighty mice were numbered and weighed and randomly divided into 8 groups, 10 in each group, and one of them was taken as the n...

Embodiment 2

[0050] Example 2: Effect of Naoxinqing on hydrocortisone-induced insulin resistance in mice

[0051] The 40 mice were numbered and weighed and randomly divided into 4 groups, with 10 mice in each group. One group was subcutaneously injected with normal saline as the normal control group, one group was subcutaneously injected with hydrocortisone (36 mg / kg), and the other two groups were Hydrocortisone (36mg / kg) was injected subcutaneously, and then the doses of Naoxinqing (20, 40mg / kg) were intragastrically administered. Each group was intragastrically administered once a day. The normal control group and the hydrocortisone group were given equal volumes of normal saline for 10 consecutive days. After 2 hours of the last administration, the control group received an equal volume of normal saline ip. In the group ip insulin (0.5g / kg), blood was taken from eyes 0.5 and 2 hours after ip glucose respectively, serum was separated, and blood glucose was measured by automatic biochemi...

Embodiment 3

[0055] Example 3: Effect of Naoxinqing on Streptozotocin Type Diabetic Model Rats

[0056] Drugs and reagents: Streptozotocin (STZ), product of Sigma Company in the United States; sodium citrate, product of Shantou Guanghua Chemical Factory, batch number 20000116.

[0057] The subjects of the experiment were 36 female Wistar normal grade rats, weighing 220-250g. (Provided by the Experimental Animal Center of First Military Medical University, certificate number: Yuejian Zhengzi No. 2004B023)

[0058] After all rats were fed adaptively for one week, they were fasted for 12 hours, and 7 rats were taken as the normal control group (abbreviated as the control group). pH4.5 sodium citrate buffer solution, used within 10min), the control group was injected with the same amount of sodium citrate solution. After 72 hours, the rats with blood glucose FBG greater than 16.7mmol / L were hyperglycemic diabetic model rats. Diabetic rats were randomly divided into diabetes model group and ...

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Abstract

An application of the extract of persimmon leaf in ethyl acetate in preparing the medicines to prevent and treat the diseases associate with glycolipid metabolism (such as hyperglycemia, diabetes, hyperlipemia, and hypertension) and metabolism syndrome is disclosed.

Description

technical field [0001] The present invention relates to the use of ethyl acetate extract of persimmon leaves in the field of medicine, specifically, the use of ethyl acetate extract of persimmon leaves for preparing medicines and / or health products for preventing and / or treating diseases related to glucose and lipid metabolism , wherein the diseases related to glucose and lipid metabolism include hyperglycemia, diabetes and metabolic syndrome, especially Alzheimer's disease. Background technique [0002] At present, the Chinese patent medicine "Naoxinqing Tablet" made of ethyl acetate extract of persimmon leaves is mainly used for the treatment of cerebral arteriosclerosis, transient ischemic attack, cerebral thrombosis, sequelae of cerebral thrombosis, coronary artery disease, etc. Heart disease, angina pectoris and other diseases have been clinically used for many years, but there are no reports on the prevention and / or treatment of glucose and lipid metabolism diseases su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/00A61P3/10A61P25/28
Inventor 李楚源贝伟剑利幼罗杰
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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