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Method for extracting active constituent from Tibetan capillary

An extraction method and technology for active ingredients, which are applied in the field of extracting active ingredients of Cang Yin Chen, can solve the problems of inability to remove small molecular impurities, difficulty in removing proteins, fibers, and low content of active ingredients, so as to reduce the incidence of adverse reactions and improve the use of crude drugs. dose, the effect of dose reduction

Active Publication Date: 2007-10-17
TIBENTAN RIKEZE ZANGNUO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some injections use water extraction and alcohol precipitation or alcohol extraction water precipitation, it is difficult to remove protein and fiber, and precipitation occurs after long-term storage (Zhao Xinxian, Traditional Chinese Medicine Injection, 1998, 146-148); some injections are extracted by water and alcohol, and centrifugal ultrafiltration can remove Particle impurities and macromolecular substances can be removed, but small molecular impurities cannot be removed, and traditional Chinese medicine injection requires more than 70% of the effective parts, and its application is limited; tablets are extracted with ethanol and directly concentrated and compressed without separation. The content of active ingredients is lower, and the dose needed to be taken each time is larger

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 10 kg of capillary capsicum and cut it into sections, add 70% ethanol for reflux extraction three times, each time for 1.5 hours, each time add 70% ethanol 60L. Combine the extracts, filter, concentrate the filtrate under reduced pressure until it has no alcohol smell, add water to 10L, stir evenly, let it stand for 15 hours, take the supernatant, add it to a macroporous adsorption resin D101 column (15cm×100cm), wash with 60L of water, After washing with 30% ethanol, and then eluting with 40L of 70% ethanol, the eluate was collected, concentrated under reduced pressure, dried under vacuum at 70°C, and pulverized to obtain the finished product.

Embodiment 2

[0019] Take 10 kg of capillary wormwood and pulverize it, add 30% ethanol to ultrasonic, each time for 0.5 hours, add 100 L of 30% ethanol each time. The ultrasonic frequency is 33kHz and the power is 350W. Combine the extracts, filter, concentrate the filtrate under reduced pressure until it has no alcohol smell, add water to 5L, stir evenly, add 1000ml of 5% 101 fruit juice clarifier under stirring, let it stand for 3 hours, and centrifuge at 5000rpm / min for 30 minutes, and the supernatant is passed through Centrifuge at 15000rpm / min, get the supernatant and add it to the macroporous adsorption resin D201 column (15cm × 100cm), wash with 15L of water, then wash with 40% ethanol, then elute with 10L of 80% ethanol, collect the eluate, reduce Concentrate under reduced pressure, dry in vacuum at 70°C, and pulverize to obtain the finished product.

Embodiment 3

[0021] Take 10kg of capillary wormwood, soak in water for 30 minutes, decoct and extract 3 times, each time for 2 hours, add water 100L, 80L, 80L each time. Combine the extracts, filter, concentrate the filtrate under reduced pressure until it has no alcohol smell, add water to 10L, stir evenly, take the filter paper pulp, spread it evenly on the filter cloth of the centrifugal filter, take the medicine solution and filter, take the filtrate and add it to the large Pore ​​adsorption resin Lk002 column (30cm×100cm), washed with 200L of water, then eluted with 50L of 70% ethanol, collected the eluate, concentrated with a double-effect concentrator, dried in vacuum at 60°C, and pulverized to obtain the finished product.

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PUM

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Abstract

The invention discloses a method for extracting anagallidium effective components with a producing steps of extracting, removing the impurity, primary separation, absorbing separation, concentrating, drying, smashing, secondary refining and etc. The extracting method extracts by solvent water and ethanol which can be recovered and has no pollution. The ultrasonic accessory extraction can shorten the extraction period, improves the efficiency, reduces energy consumption. The centrifugation and large-hole resin absorption treatments can keep the effective components, remove the impurity in a high limit, refine the Chinese traditional medicine, reduce dosage and facilitate to dispose a plurality of preparation formulation containing injection (intravenous injection ), oral reagent, external use regent, and also can be the material of the compound preparation. Meanwhile, it can reduce the side effects and bad reaction incidence rate because the impurity is removed throughly.

Description

Background technique [0001] Tibetan Yinchen is a traditional medicinal material used in Tibetan medicine to treat various diseases such as hepatitis, cholecystitis, liver injury, liver fibrosis, and fatty liver. It belongs to the Gentianaceae Swertia plant. Anti-yellowing effect. The research data show that Capillary chinensis contains a variety of chemical components, the main active ingredient is oleanolic acid, and picrosides mainly including swertiamarin, swertiaroside and gentiopicroside, and flavin as the main ingredient. Main flavonoids, mangiferin-based flavonoid glycosides (Yang Huiling, Liu Jianjian, Study on 7 effective chemical components in 9 kinds of "Zang Yinchen" original plants, Chinese Herbal Medicine, 2005, 36(8), 1233-1237) , the above-mentioned ingredients have various activities such as treating liver poisoning, clearing away heat, reducing inflammation, protecting the liver, reducing transaminase, anti-oxidation, and antibacterial. Oral solid preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/515A61P1/16
Inventor 王智森
Owner TIBENTAN RIKEZE ZANGNUO PHARMA CO LTD
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