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Terpolymer for controllable degradation of carbon dioxide/epoxide/lactone and preparation method thereof

A technology of terpolymer and epoxy, which is applied in the field of polymer chemistry, can solve problems such as unsatisfactory degradation rate, and achieve the effects of improving physical and mechanical properties, increasing molecular weight, and improving degradation performance

Inactive Publication Date: 2007-10-17
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, aliphatic polycarbonate has been more and more widely used in the fields of drug control release, in vivo implant materials and tissue engineering. However, although aliphatic polycarbonate has good biocompatibility, its degradation rate is not ideal.

Method used

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  • Terpolymer for controllable degradation of carbon dioxide/epoxide/lactone and preparation method thereof
  • Terpolymer for controllable degradation of carbon dioxide/epoxide/lactone and preparation method thereof
  • Terpolymer for controllable degradation of carbon dioxide/epoxide/lactone and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0016] Preparation of the terpolymer (PPCG) of carbon dioxide / propylene oxide / γ-butyrolactone: the polymerization reaction was carried out in a 300mL magnetic autoclave. Propylene oxide 50mL, benzene 50mL, γ-butyrolactone and propylene oxide are in a certain ratio, respectively 0:5, 1:5, 2:5, 3:5, 4:5, 5:5, fully stirred for 0.5h , then pass into the CO 2 The pressure of the gas to the reaction system is 3.5-4Mpa. Heated, polymerized at 60°C for 24h, stopped heating and stirring, cooled to room temperature, and discharged the remaining gas. After discharging, the copolymer was washed with 5% hydrochloric acid ethanol, washed three times with ethanol, and dried to obtain a crude product. Dissolve in dichloromethane, centrifuge to remove insoluble matter and residual catalyst, evaporate to remove solvent, and vacuum dry at 35°C until constant weight. The polymers PPC, PPCG1, PPCG2, PPCG3, PPCG4, PPCG5 were obtained respectively. Their viscosity-average molecular weights are:...

Embodiment 2

[0018] Preparation of the terpolymer (PPCCL) of carbon dioxide / propylene oxide / ε-caprolactone: the polymerization reaction was carried out in a 300mL magnetic autoclave. Propylene oxide 50mL, toluene 60mL, ε-caprolactone and propylene oxide are in a certain ratio, respectively 1:3, 2:3, 3:3, after fully stirring for 0.5h, then introduce CO 2 The pressure of the gas to the reaction system is 3.5-4Mpa. Heated, polymerized at 60°C for 24h, stopped heating and stirring, cooled to room temperature, and discharged the remaining gas. After discharging, the copolymer was washed with 5% hydrochloric acid ethanol, washed three times with ethanol, and dried to obtain a crude product. Dissolve in dichloromethane, centrifuge to remove insoluble matter and residual catalyst, evaporate to remove solvent, and vacuum dry at 35°C until constant weight. The polymers PPCCL1, PPCCL2 and PPCCL3 were obtained respectively. Their viscosity-average molecular weights are: 51200, 67100, 57300 respect...

Embodiment 3

[0020] Preparation of terpolymer (PBCCL) of carbon dioxide / 1,2 epoxybutylene / ε-caprolactone: The polymerization reaction was carried out in a 300mL magnetic autoclave, and after purging the autoclave with nitrogen for 10min, the catalyst was quickly added 1.00g, 32mL of 1,2-butylene oxide, 50mL of toluene, ε-caprolactone and 1,2-butylene oxide in a certain ratio, respectively 0:4, 1:4, 2:4, 3:4, 4:4, after fully stirring for 0.5h, then introduce CO 2 The pressure of the gas to the reaction system is 3.5-4Mpa. Heated, polymerized at 70°C for 36h, stopped heating and stirring, cooled to room temperature, and discharged the remaining gas. After discharging, the copolymer was washed with 5% hydrochloric acid ethanol, washed three times with ethanol, and dried to obtain a crude product. Dissolve in dichloromethane, centrifuge to remove insoluble matter and residual catalyst, evaporate to remove solvent, and vacuum dry at 35°C until constant weight. The polymers PBC, PBCCL1, PBCC...

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Abstract

A ter-copolymer for controlling to degrade carbon dioxide / epoxide / lactone and the producing method thereof are provided. The ter-copolymer is named of lactone-epoxide-carbon dioxide. The invention increases the polycarbonate hydrophilicity and biodegradation capacity by introducing the lactone unit containing easy hydrolysis group and bonding easy hydrolysis group on the aliphatic polycarbonate molecular chain and regulates the polycarbonate degradation speed and further achieves the controlled material degradation by controlling the content of the ester-containing unit.

Description

technical field [0001] The invention relates to a controllable biodegradable aliphatic polycarbonate and a preparation method thereof, belonging to the field of polymer chemistry. Background technique [0002] So far, the clinical application in the field of biomedical polymer materials is mainly polyester materials, such as polyethylene glycol, polycaprolactone, polylactic acid (PLA) and its copolymer with polyglycolide ( PLGA) etc. During the degradation process, polyester materials will release a large amount of acidic substances, which will cause non-infectious inflammatory reactions in the later stage of treatment. However, the aliphatic polycarbonate prepared directly from carbon dioxide and epoxy compounds, because of its good biocompatibility and degradability, and generates carbon dioxide and neutral diols after degradation, can avoid non-infectious diseases in the later stage of treatment. Generation of inflammatory response. Therefore, aliphatic polycarbonate h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G64/34C08G64/38
Inventor 黄可龙刘素琴刘艳飞黄健涵王蔚玲卢凌冰吴弘肖寒
Owner CENT SOUTH UNIV
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