Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers

A technology of bilurin and medicine, which is applied in the field of preparation of the medicinal ingredient rischolin, and can solve problems such as reports on the application of rischolin that have not yet been found

Active Publication Date: 2007-11-21
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on the

Method used

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  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers
  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers
  • Preparation of hemsleyadine-A and its use of preparing pharmaceutics against cancers

Examples

Experimental program
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Embodiment 1

[0050] Embodiment 1: Take 5 kg of Luoguo bottom in Qiaojia County, Yunnan, grind it into medium powder, put it into a seepage container, add 24 times the amount of acetone to soak for 48 hours at 15-25 ° C, and then carry out percolation according to the Chinese Pharmacopoeia percolation method , reclaim the percolation liquid, mix the extract into an equal amount of silica gel, dry at 50-70°C, put it on a silica gel column, use chloroform: methanol as the eluent to carry out gradient elution, and collect the eluent at a concentration of 3-5% methanol After recovery, the crude product can be obtained, which is recrystallized several times with methanol to obtain columnar crystals with a melting point of 226-228°C and a purity of 98.98% by HPLC analysis. As shown in Figure 1, it was confirmed to be bilbacetin through four-spectrum analysis of ultraviolet, infrared, nuclear magnetic resonance and mass spectrometry.

[0051] Taking the above-mentioned pectin as a monomer componen...

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PUM

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Abstract

Production of medicinal component snow bile pigment and its usage for preparing medicines in treatment of cancers are disclosed. The process is carried out by taking snow bile plant tuber, crushing, taking acetone 18-26 proportion as solvent, extracting by diacolation method, recovering extract in water-bath kettle at 60-75 degree to obtain extractive, adding extractive into silica gel 1-2 proportion, drying to obtain silica-gel column, gradient eluting by ethanol or chloroform with volume concentration 2-10%, recovering eluent to obtain coarse product, heating while dissolving for ethanol or alcohol in water bath, filtering, lowering to room temperature, re-crystallizing to obtain prism crystal with purity above 98%. It can be used to prepare medicines in treatment of hepatocarcinoma, lung cancer, gastric carcinoma, laryngeal cancer and leukemia.

Description

technical field [0001] The invention relates to a preparation method of the medicinal ingredient gentamicin and its new application in the preparation of medicines for treating cancer. Background technique [0002] Echobilisin is a mixture consisting of escobilin and escobilin. It was first isolated from the root of Hemsleya amalils Diels by Chen Weixin et al. (Acta Chemica Sinica, 1975, 33(1), 5). Hemsleya amalils were identified as 19--decarb-9β- Methyl-10à-3à-hydrogen-2β,3à,16à,20,25-pentahydroxylanosterene-11,20-diketone-25-acetate (IIa) is 23.24 of cucurbitacin F (Ic) -cc dihydro-25-acetate, B identified as the 23,24-dihydro compound of cucurbitacin F (Ic), two new compounds, and the development of snow gallin tablets, received in 1974 Contained in the drug standard of Yunnan Province, it is used to treat bacillary dysentery, bronchitis, and acute tonsillitis. [0003] In order to find plant resources for extracting pectin, some scholars have carried out resource che...

Claims

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Application Information

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IPC IPC(8): C07J9/00A61K31/575A61P35/00
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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