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Nano particle of enwrapping water-soluble active ingredient, and preparation method

An active ingredient and nanoparticle technology, applied in the field of W/O type nanoparticles, can solve the problems affecting the performance of the final product, poor efficacy, etc., and achieve the effect of obvious stable protection, high drug loading rate and high stability.

Inactive Publication Date: 2007-12-26
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of such derivatives is worse than that before modification, which affects the performance of the final product

Method used

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  • Nano particle of enwrapping water-soluble active ingredient, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 0.15g vitamin C dry powder and add it into 50mL water to dissolve, and adjust the pH value to 2.0. Dissolve 3.0g span80 and 0.6g tween80 in 50mL n-hexane, add 1mL vitamin C aqueous solution dropwise into the oil phase with emulsifier dissolved under ultrasonic vibration, stir for 0.5 hours to make the system uniform and stable and maintain a relatively transparent and clear state , and accompanied by a blue light phenomenon, showing a uniform microemulsion. Slowly add 0.02 g of α-butyl cyanoacrylate monomer dropwise into the emulsified system under stirring, and react at room temperature for 15 hours. After the reaction, the system was centrifuged at a speed of 5000 r / min for 10 minutes, and the supernatant was removed to obtain the precipitated milky white solid nano drug-loaded particles, which were polymeric particles encapsulating the water-soluble active ingredients. Ethyl cyanoacrylate nanoparticle drug-loaded particles. As shown in Figure 1, the particle s...

Embodiment 2

[0018] Take 0.15g vitamin C dry powder and add it to 50mL water to dissolve, and adjust the pH value to 3.0. Dissolve 3.0g span80 and 0.6g tween80 in 50mL n-hexane, add 1mL vitamin C aqueous solution dropwise into the oil phase with emulsifier dissolved under ultrasonic vibration, stir for 0.5 hours to make the system uniform and stable and maintain a relatively transparent and clear state , and accompanied by a blue light phenomenon, showing a uniform microemulsion. Slowly add 0.15 g of α-butyl cyanoacrylate monomer dropwise into the emulsified system under stirring, and react for another 15 hours at room temperature. After the reaction, the system was centrifuged at a speed of 5000 r / min for 10 minutes to remove the supernatant to obtain the precipitated milky white solid nano drug-loaded particles, which are the water-soluble active ingredients. Polyethylene cyanoacrylate nano drug-loaded particles. The particle size of the prepared microspheres was 380nm at 25°C, the dru...

Embodiment 3

[0020] Take 0.15g vitamin C dry powder and add it into 50mL water to dissolve, and adjust the pH value to 4.0. Dissolve 3.0g span80 and 0.6g tween80 in 50mL n-hexane, add 1mL vitamin C aqueous solution dropwise into the oil phase with emulsifier dissolved under ultrasonic vibration, stir for 0.5 hours to make the system uniform and stable and maintain a relatively transparent and clear state , and accompanied by a blue light phenomenon, showing a uniform microemulsion. Slowly add 0.02 g of α-butyl cyanoacrylate monomer dropwise into the emulsified system under stirring, and react for another 15 hours at room temperature. After the reaction, the system was centrifuged at a speed of 5000 r / min for 10 minutes to remove the supernatant to obtain the precipitated milky white solid nano drug-loaded particles, which are the water-soluble active ingredients. Polyethylene cyanoacrylate nano drug-loaded particles. The particle size of the prepared microspheres is 450nm at 25°C, the dr...

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Abstract

This invention discloses a method for preparing nanoparticles containing water-soluble active component. The cores are composed of water-soluble active component, and the shells are composed of polymer of alkyl alpha-cyanoacrylate monomer. The average diameter of the nanoparticles at 25 deg.C is 100-500 nm. The water-soluble active component is one or more of vitamin C, vitamin B, hyaluronic acid and hyaluronic acid derivatives. The alkyl alpha-cyanoacrylate monomer is ethyl alpha-cyanoacrylate monomer or butyl alpha-cyanoacrylate monomer. The carrier material has such advantages as high biocompatibility, and high safety in cosmetic field. The method has such advantages as simple operation and high stability. The obtained nanoparticles have such advantages as small and uniform sizes, high permeability to skin, high drug loading rate, and stable protection of sensitive active substances.

Description

technical field [0001] The invention relates to a W / O nano particle prepared by an interfacial polymerization method, and more specifically relates to a nano particle coated with a water-soluble active ingredient that can be used in cosmetics and has penetration and sustained release functions and a preparation method thereof. Background technique [0002] Drug sustained release technology appeared in the 1980s, and it is a very effective way to realize drug sustained release technology with nanometer controlled release drug carriers. Applying this technology to the field of cosmetics, the obtained active substance nanoparticles have excellent characteristics such as strong penetrating power, good slow-release effect, not easy to lose, and sensitive components are protected, which can effectively improve the absorption of nutrients by the epidermis and hair follicle glands in the skin. Absorption efficiency, avoiding the loss of active ingredients along with the loss of cosm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/08C08F2/44C08F2/30A61K47/32
Inventor 章苏宁郭奕光周磊
Owner SHANGHAI INST OF TECH
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