Preparation of self-assembly bionic phospholipid polyalcohol organization plasmalemma and application thereof

A bionic phospholipid and polymer technology, applied in medical science, prosthesis, surgery, etc., can solve problems such as high cost, high degree of model automation, and inconvenient testing
CN101108260BInactive Publication Date: 2011-06-22DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2011-06-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method and application of a self-assembled biomimetic phospholipids polymer membrane. The preparation steps comprise (1) monomer preparation and (2) oligomer preparation. Connect the hydrophilic phospholipids groups and their derivatives with the dual bonds hydrophobic aliphatic hydrocarbons and synthesize a self-assembled microcosmic heterogeneous phase similar to the biological membrane. The invention can imitate PH values of different organs by adjusting the PH value of the penetrant liquid, or can regulate the stability and flexibility of the phospholipid polymer by controlling the polymer molecular size, the hydrophobic chain length and the phospholipid content. The membrane coverage and thickness can be adjusted according to requirements while the single or double layer membrane can be made according to the molecule's PH value change with the environment. The preparation method is fast and easy, low cost and can be kept for a long time, helps to accelerate the new medicine discovery and development. The invention is applied to bring various polarized phospholipids and their derivatives such as lecithin and cephalin on the hydrophobic chain, and set up the simulation cell membrane model with different targets.
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Description

technical field

[0001] The invention belongs to the technical field of polymer material membranes, and in particular relates to the preparation of a self-assembled biomimetic phospholipid polymer tissue cell membrane and its application in drug penetration. Background technique

[0002] Bioavailability is one of the important indicators to measure whether a drug can be developed into an effective clinical drug. The bioavailability of drugs is affected by a series of factors. It has been reported that 80% of drugs penetrate into the blood through non-spontaneous diffusion of intestinal epithelial cells. Studies have shown that absorbability data can be used for in vitro activity analysis in early drug development.

[0003] In the past ten years, tissue cell models have been widely used abroad as a tool for drug absorption research, mainly including Caco-2 cell monolayer model and MDCK cell model.

[0004] The Caco-2 cell model is derived from human colon cancer cells and is...

Claims

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