35results about How to "Easy self-assembly" patented technology

The invention discloses a preparation method of a magnetic molecular imprinting photonic crystal sensor for detecting melamine and belongs to the technical field of molecular imprinting photonic crystal and analysis detection. The product is obtained through preparation of oleic acid modified ferroferric oxide magnetic nanoparticles, preparation of melamine magnetic molecular imprinting nanoparticles and preparation of the magnetic molecular imprinting photonic crystal sensor. The melamine magnetic molecular imprinting nanoparticles are self-assembled to form a photonic crystal structure under the action of an external magnetic field, and a liquid-state molecular imprinting photonic crystal sensor is obtained. On a macro level, with increase of the concentration of melamine, the diffraction color of the sensor changes from weak purple to green, yellow and finally orange red. The preparation method has the advantages that the photonic crystals are assembled rapidly, simply and conveniently. The provided molecular imprinting photonic crystal sensor transmits a chemical signal of melamine concentration change directly through an optical signal of diffraction color change and realizes the purpose of naked eye detection.

The invention relates to a preparation method and application of a self-assembled biomimetic phospholipids polymer membrane. The preparation steps comprise (1) monomer preparation and (2) oligomer preparation. Connect the hydrophilic phospholipids groups and their derivatives with the dual bonds hydrophobic aliphatic hydrocarbons and synthesize a self-assembled microcosmic heterogeneous phase similar to the biological membrane. The invention can imitate PH values of different organs by adjusting the PH value of the penetrant liquid, or can regulate the stability and flexibility of the phospholipid polymer by controlling the polymer molecular size, the hydrophobic chain length and the phospholipid content. The membrane coverage and thickness can be adjusted according to requirements while the single or double layer membrane can be made according to the molecule's PH value change with the environment. The preparation method is fast and easy, low cost and can be kept for a long time, helps to accelerate the new medicine discovery and development. The invention is applied to bring various polarized phospholipids and their derivatives such as lecithin and cephalin on the hydrophobic chain, and set up the simulation cell membrane model with different targets.

The invention discloses a method for constructing a slow release system for medicament on surface of a medical titanium alloy implant. The system is characterized in that the method comprises the following steps: a solvent blending method is used for grafting maleic anhydride to polylactic acid in order to prepare maleic anhydride grafted polylactic acid; MPLA microballoons containing streptomycin sulphate is prepared by a self-assembly balling method; surface amination of titanium alloy is carried out by surface grafting modification, so that the surface of titanium has positive charges, a layer by layer assembly technology is used, the MPLA microballoons and PEI are used as negative and positive ions respectively, static adsorption is used, and an SS-MPLA microballoon/PEI multilayer antibacterial film is constructed on the surface of the titanium material. When the multilayer antibacterial film on the surface of the implant in vivo is degraded, streptomycin sulphate is slowly released, so that long-term bacteriostasis effect is realized, and the system has the effects of good compatibility, high stability, firm combination, and long slow release time.

The invention relates to a preparation method of a disulfide bond cross-linked C3 polypeptide supermolecule helical polymer. C3 polypeptide monomers can form the supermolecule helical polymer through layer-by-layer self-assembly in a tetrahydrofuran solution, and a disulfide bond can be obtained through sulfydryl crosslinking on an oxidation polypeptide side chain to obtain the disulfide bond cross-linked C3 polypeptide supermolecule helical polymer. The assembly chirality of the disulfide bond cross-linked C3 polypeptide supermolecule helical polymer is not greatly changed along with increasing of temperature within a certain temperature interval; the assembly can stably exist and keeps a left-hand helical structure under a good solvent. The supermolecule helical polymer has the advantages of being easy to synthesize, reliable in chirality and stable in structure, and can be applied in the fields of chiral recognition, chiral separation, asymmetry catalysis and the like.

The invention discloses a preparation method of homocyclic peptide Cyclo-[(Asp)5-Gly]. The method includes: (1) connection of resin with protective group equipped aspartic acid to form aspartic acid connected resin; (2) sequential condensation of the aspartic acid connected to resin with the protective group equipped aspartic acid and allylglycine to form linear peptide connected resin; (3) cutting of the linear peptide off the resin and end-to-end cyclization to obtain a cyclic peptide crude product; and (4) purification and preservation of cyclic peptide. The Cyclo-[(Asp)5-Gly] prepared by the invention is a homocyclic peptide structure, has a molecular structure with better regularity, is easier for self-assembly into an ion channel or nanotube, thus serving as a drug carrier, membrane channel, molecular device and the like. The five carboxyl functional groups contained on a side chain endow the product with certain water solubility and bioactivity, also an allyl functional group contained on the side chain endows the product with better reaction activity, so that the product can be used as a precursor reagent for high efficient click reaction. At the same time, the method has the advantages of reasonable process, simple operation, and high synthesis efficiency.

The invention relates to a tripolyindole compound, and a preparation method and use thereof. The tripolyindole compound is shown in formula I, wherein R and X are defined in the specification. The tripolyindole compound provided by the invention comprises a large-pi conjugate soluble parent nucleus structural unit, and push-pull structural side chains of a conjugate electron donor and/or a receptor, and is a low-energy gap small molecular compound; and the compound has wide application prospect in solar battery devices.

The embodiment of the invention discloses a method of preparing platinum nano cage, relates to the technical field of synthesis technology field of nano materials, and the preparation method includesthe following steps: a. preparation of gold nano particle seed solution; b. preparation of angular octahedral gold nanoparticle solution; c. preparation of platinum-coated angle-cutting octahedral gold nanoparticle solution; d. the octahedral gold nano particles are etched to obtain the octahedral platinum nano cage solution. The preparation method comprises the following steps prepare corner-cutting octahedron gold nanoparticles by using the solution phase gradual growth method; selectively growing platinum on the corners of the corner-cutting octahedron by using the solution phase method; and selectively etching most gold to generate the corner-cutting octahedron platinum nano cage; the cut-angle octahedral platinum nano cage with a plurality of edges and corners is mixed with platinum nano cage is self-assembled into an orderly arranged porous film which has long-term stability and higher specific surface area and important application potential in the field of catalysis.

The invention relates to stone-crash-resistant automobile corrosion-resistant wax and a preparation method thereof, and belongs to the technical field of metal corrosion prevention. The characteristicthat environment-friendly phytic acid compounds inositol hexaphosphoric acid and tannic acid are liable to be self-assembled on the surface of metal to form a film is utilized; when the environment-friendly phytic acid compounds inositol hexaphosphoric acid and tannic acid are contacted with the surface of the metal, the two anti-rust groups are chelated with the surface of the metal to generateone layer of compact passivation film, and composite paraffin is met and guided to gradually form a protective wax film on the surface of plate material; on the other hand, the two anti-rust groups have optimal compatibility with metal polymers with excellent corrosion resistance such as titanium and aluminum in the metal, the two anti-rust group and a film-forming substance jointly form a corrosion-resistant layer with high compactness on the surface of the metal, and the corrosion-resistant layer has extremely high barrier property on erosion and corrosion mediums such as water, oxygen and ions. The corrosion-resistant wax prepared by the method has extremely high barrier property and high stone crash resistance, is applied to the surface and the hole gap of the material by a spray-coating mode, and has high long-time corrosion resistance.

The invention discloses a pharmaceutical betaine conjugate and a pharmaceutical composition and an application thereof. The pharmaceutical composition contains the pharmaceutical betaine conjugate or a pharmaceutic composition composed of the pharmaceutical betaine conjugate and a pharmacologically acceptable carrier and is made into liquid preparations, solid preparations, semi-solid preparations, capsules, granules, gels and injections. The pharmaceutical composition is of liposomal nano-particles made of the pharmaceutical betaine conjugate or the composition of the pharmaceutical betaine conjugate and auxiliaries, to be specific, 10-100nm in particle size. The pharmaceutical betaine conjugate and the liposomal nano-particles thereof can serve as the liquid preparations, the solid preparations, the semi-solid preparations, sterilization preparations and sterile preparations and are low in toxicity and applicable to various tumor efficient treatments.

The invention discloses a recombinant FCV antigen and a Feline calicirus genetic engineering subunit vaccine. The recombinant FCV antigen comprises two proteins with the sequences shown as SEQ ID NO: 2 and SEQ ID NO: 3 respectively. The vaccine comprises the recombinant FCV antigen and a pharmaceutically acceptable carrier. The recombinant FCV antigen provided by the invention is easy for self-assembly to form a virus-like particle (VLP) with stable structure and excellent immunogenicity. The VLP has shape, stability and immunogenicity close to those of a wild virion, and can be prepared by large-scale serum-free suspension culture in a bioreactor through an insect cell expression system along with high expression level and good protein immunotherapy. The prepared vaccine is easy in quality control, stable in batches and low in production cost.

The invention discloses a tool for installing and fixing a valve seat of a valve. The tool includes a butterfly screw (1), a gasket cover (2), a round nut (3), a steel pipe (4), a pull rod (5), an elastic sleeve ( 6) and the cone (7), one end of the tie rod (5) is screwed to the center of the cone (7), the cone (7) is inserted into the elastic sleeve (6), and one end of the steel pipe (4) is connected to the elastic sleeve (6) ), the round nut (3) is screwed on the external thread of the steel pipe (4), the other end of the steel pipe (4) is covered with the gasket cover (2), and the other end of the tie rod (5) protrudes from the gasket cover (2) And screw on thumb screw (1), integrally constitutes tool. The invention has the advantages of simple structure, easy understanding and convenient operation, thereby greatly improving the assembly efficiency of the valve.