35results about How to "Easy self-assembly" patented technology

The invention relates to benzo terthiophene compound as well as a preparation method and usage thereof. The structure of the benzo terthiophene compound is expressed by a formula I, and in the formula, the definition of X is described in the description. The benzo terthiophene compound provided by the invention has a large phi conjugated and soluble mother nucleus structure unit and a conjugated electron donor and / or receptor side chain with a push-pull structure and is a low-energy gap micro-molecular compound, and the benzo terthiophene compound has an extensive application prospect in solar cell devices.

The invention discloses a preparation method of a magnetic molecular imprinting photonic crystal sensor for detecting melamine and belongs to the technical field of molecular imprinting photonic crystal and analysis detection. The product is obtained through preparation of oleic acid modified ferroferric oxide magnetic nanoparticles, preparation of melamine magnetic molecular imprinting nanoparticles and preparation of the magnetic molecular imprinting photonic crystal sensor. The melamine magnetic molecular imprinting nanoparticles are self-assembled to form a photonic crystal structure under the action of an external magnetic field, and a liquid-state molecular imprinting photonic crystal sensor is obtained. On a macro level, with increase of the concentration of melamine, the diffraction color of the sensor changes from weak purple to green, yellow and finally orange red. The preparation method has the advantages that the photonic crystals are assembled rapidly, simply and conveniently. The provided molecular imprinting photonic crystal sensor transmits a chemical signal of melamine concentration change directly through an optical signal of diffraction color change and realizes the purpose of naked eye detection.

The invention relates to a preparation method and application of a self-assembled biomimetic phospholipids polymer membrane. The preparation steps comprise (1) monomer preparation and (2) oligomer preparation. Connect the hydrophilic phospholipids groups and their derivatives with the dual bonds hydrophobic aliphatic hydrocarbons and synthesize a self-assembled microcosmic heterogeneous phase similar to the biological membrane. The invention can imitate PH values of different organs by adjusting the PH value of the penetrant liquid, or can regulate the stability and flexibility of the phospholipid polymer by controlling the polymer molecular size, the hydrophobic chain length and the phospholipid content. The membrane coverage and thickness can be adjusted according to requirements while the single or double layer membrane can be made according to the molecule's PH value change with the environment. The preparation method is fast and easy, low cost and can be kept for a long time, helps to accelerate the new medicine discovery and development. The invention is applied to bring various polarized phospholipids and their derivatives such as lecithin and cephalin on the hydrophobic chain, and set up the simulation cell membrane model with different targets.

The invention discloses a method for constructing a slow release system for medicament on surface of a medical titanium alloy implant. The system is characterized in that the method comprises the following steps: a solvent blending method is used for grafting maleic anhydride to polylactic acid in order to prepare maleic anhydride grafted polylactic acid; MPLA microballoons containing streptomycin sulphate is prepared by a self-assembly balling method; surface amination of titanium alloy is carried out by surface grafting modification, so that the surface of titanium has positive charges, a layer by layer assembly technology is used, the MPLA microballoons and PEI are used as negative and positive ions respectively, static adsorption is used, and an SS-MPLA microballoon / PEI multilayer antibacterial film is constructed on the surface of the titanium material. When the multilayer antibacterial film on the surface of the implant in vivo is degraded, streptomycin sulphate is slowly released, so that long-term bacteriostasis effect is realized, and the system has the effects of good compatibility, high stability, firm combination, and long slow release time.

The invention relates to a preparation method of a disulfide bond cross-linked C3 polypeptide supermolecule helical polymer. C3 polypeptide monomers can form the supermolecule helical polymer through layer-by-layer self-assembly in a tetrahydrofuran solution, and a disulfide bond can be obtained through sulfydryl crosslinking on an oxidation polypeptide side chain to obtain the disulfide bond cross-linked C3 polypeptide supermolecule helical polymer. The assembly chirality of the disulfide bond cross-linked C3 polypeptide supermolecule helical polymer is not greatly changed along with increasing of temperature within a certain temperature interval; the assembly can stably exist and keeps a left-hand helical structure under a good solvent. The supermolecule helical polymer has the advantages of being easy to synthesize, reliable in chirality and stable in structure, and can be applied in the fields of chiral recognition, chiral separation, asymmetry catalysis and the like.

The invention discloses a preparation method of homocyclic peptide Cyclo-[(Asp)5-Gly]. The method includes: (1) connection of resin with protective group equipped aspartic acid to form aspartic acid connected resin; (2) sequential condensation of the aspartic acid connected to resin with the protective group equipped aspartic acid and allylglycine to form linear peptide connected resin; (3) cutting of the linear peptide off the resin and end-to-end cyclization to obtain a cyclic peptide crude product; and (4) purification and preservation of cyclic peptide. The Cyclo-[(Asp)5-Gly] prepared by the invention is a homocyclic peptide structure, has a molecular structure with better regularity, is easier for self-assembly into an ion channel or nanotube, thus serving as a drug carrier, membrane channel, molecular device and the like. The five carboxyl functional groups contained on a side chain endow the product with certain water solubility and bioactivity, also an allyl functional group contained on the side chain endows the product with better reaction activity, so that the product can be used as a precursor reagent for high efficient click reaction. At the same time, the method has the advantages of reasonable process, simple operation, and high synthesis efficiency.

The invention relates to a tripolyindole compound, and a preparation method and use thereof. The tripolyindole compound is shown in formula I, wherein R and X are defined in the specification. The tripolyindole compound provided by the invention comprises a large-pi conjugate soluble parent nucleus structural unit, and push-pull structural side chains of a conjugate electron donor and / or a receptor, and is a low-energy gap small molecular compound; and the compound has wide application prospect in solar battery devices.

The embodiment of the invention discloses a method of preparing platinum nano cage, relates to the technical field of synthesis technology field of nano materials, and the preparation method includesthe following steps: a. preparation of gold nano particle seed solution; b. preparation of angular octahedral gold nanoparticle solution; c. preparation of platinum-coated angle-cutting octahedral gold nanoparticle solution; d. the octahedral gold nano particles are etched to obtain the octahedral platinum nano cage solution. The preparation method comprises the following steps prepare corner-cutting octahedron gold nanoparticles by using the solution phase gradual growth method; selectively growing platinum on the corners of the corner-cutting octahedron by using the solution phase method; and selectively etching most gold to generate the corner-cutting octahedron platinum nano cage; the cut-angle octahedral platinum nano cage with a plurality of edges and corners is mixed with platinum nano cage is self-assembled into an orderly arranged porous film which has long-term stability and higher specific surface area and important application potential in the field of catalysis.

The invention discloses a preparation method of ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under urea action. The preparation method comprises the following steps: adding solublesalt ferric trichloride, sodium chloride and urea of certain amount into absolute ethyl alcohol and deionized water to obtain suspension A; pouring the suspension A into a homogeneous-phase hydrothermal reaction kettle, and sealing the reaction kettle; putting the reaction kettle in a homogeneous-phase hydrothermal reaction instrument for a hydrothermal reaction; then naturally cooling to room temperature to obtain a product B; washing the product B with water and alcohol respectively, and dispersing the washed product in water to obtain a product C; performing freeze drying on the product C to obtain the ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under urea action. Through the homogeneous-phase hydrothermal process, the preparation method disclosed by the invention has the advantages of simplicity, short time, low cost and easiness in implementation; with a larger specific surface area, the ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under ureaaction can provide more electrochemical reaction active sites to improve the reaction activity of a Beta-FeOOH conversion reaction.

The invention relates to stone-crash-resistant automobile corrosion-resistant wax and a preparation method thereof, and belongs to the technical field of metal corrosion prevention. The characteristicthat environment-friendly phytic acid compounds inositol hexaphosphoric acid and tannic acid are liable to be self-assembled on the surface of metal to form a film is utilized; when the environment-friendly phytic acid compounds inositol hexaphosphoric acid and tannic acid are contacted with the surface of the metal, the two anti-rust groups are chelated with the surface of the metal to generateone layer of compact passivation film, and composite paraffin is met and guided to gradually form a protective wax film on the surface of plate material; on the other hand, the two anti-rust groups have optimal compatibility with metal polymers with excellent corrosion resistance such as titanium and aluminum in the metal, the two anti-rust group and a film-forming substance jointly form a corrosion-resistant layer with high compactness on the surface of the metal, and the corrosion-resistant layer has extremely high barrier property on erosion and corrosion mediums such as water, oxygen and ions. The corrosion-resistant wax prepared by the method has extremely high barrier property and high stone crash resistance, is applied to the surface and the hole gap of the material by a spray-coating mode, and has high long-time corrosion resistance.

The invention discloses a pharmaceutical betaine conjugate and a pharmaceutical composition and an application thereof. The pharmaceutical composition contains the pharmaceutical betaine conjugate or a pharmaceutic composition composed of the pharmaceutical betaine conjugate and a pharmacologically acceptable carrier and is made into liquid preparations, solid preparations, semi-solid preparations, capsules, granules, gels and injections. The pharmaceutical composition is of liposomal nano-particles made of the pharmaceutical betaine conjugate or the composition of the pharmaceutical betaine conjugate and auxiliaries, to be specific, 10-100nm in particle size. The pharmaceutical betaine conjugate and the liposomal nano-particles thereof can serve as the liquid preparations, the solid preparations, the semi-solid preparations, sterilization preparations and sterile preparations and are low in toxicity and applicable to various tumor efficient treatments.

The invention relates to a preparation method and application of a self-assembled biomimetic phospholipids polymer membrane. The preparation steps comprise (1) monomer preparation and (2) oligomer preparation. Connect the hydrophilic phospholipids groups and their derivatives with the dual bonds hydrophobic aliphatic hydrocarbons and synthesize a self-assembled microcosmic heterogeneous phase similar to the biological membrane. The invention can imitate PH values of different organs by adjusting the PH value of the penetrant liquid, or can regulate the stability and flexibility of the phospholipid polymer by controlling the polymer molecular size, the hydrophobic chain length and the phospholipid content. The membrane coverage and thickness can be adjusted according to requirements while the single or double layer membrane can be made according to the molecule's PH value change with the environment. The preparation method is fast and easy, low cost and can be kept for a long time, helps to accelerate the new medicine discovery and development. The invention is applied to bring various polarized phospholipids and their derivatives such as lecithin and cephalin on the hydrophobic chain, and set up the simulation cell membrane model with different targets.

The invention discloses a method for constructing a slow release system for medicament on surface of a medical titanium alloy implant. The system is characterized in that the method comprises the following steps: a solvent blending method is used for grafting maleic anhydride to polylactic acid in order to prepare maleic anhydride grafted polylactic acid; MPLA microballoons containing streptomycin sulphate is prepared by a self-assembly balling method; surface amination of titanium alloy is carried out by surface grafting modification, so that the surface of titanium has positive charges, a layer by layer assembly technology is used, the MPLA microballoons and PEI are used as negative and positive ions respectively, static adsorption is used, and an SS-MPLA microballoon / PEI multilayer antibacterial film is constructed on the surface of the titanium material. When the multilayer antibacterial film on the surface of the implant in vivo is degraded, streptomycin sulphate is slowly released, so that long-term bacteriostasis effect is realized, and the system has the effects of good compatibility, high stability, firm combination, and long slow release time.

The invention relates to a tripolyindole compound, and a preparation method and use thereof. The tripolyindole compound is shown in formula I, wherein R and X are defined in the specification. The tripolyindole compound provided by the invention comprises a large-pi conjugate soluble parent nucleus structural unit, and push-pull structural side chains of a conjugate electron donor and / or a receptor, and is a low-energy gap small molecular compound; and the compound has wide application prospect in solar battery devices.

The embodiment of the present invention discloses a method for preparing a platinum-gold nanocage, which relates to the technical field of synthesis of nanomaterials. The preparation method includes the following steps: a. preparing a gold nanometer seed solution; b. preparing an angle-cut octahedral gold nanometer Particle solution; c. preparing a solution of platinum-coated octahedral gold nanoparticles; d. etching the solution of platinum-coated octahedral gold nanoparticles to obtain a platinum-gold nanocage solution of octahedrons. The preparation method uses the solution phase stepwise growth method to prepare the cut-angle octahedral gold nanoparticles, and then selectively grows platinum on the corners of the cut-angle octahedron by using the solution phase method, and finally etches most of the gold selectively to form Cutting angle octahedral platinum-gold nanocages; the self-assembly of cutting-angle octahedral platinum-gold nanocages with many corners and corners into an ordered porous film, the film has long-term stability and high specific surface area. field has great application potential.

The invention discloses a recombinant FCV antigen and a Feline calicirus genetic engineering subunit vaccine. The recombinant FCV antigen comprises two proteins with the sequences shown as SEQ ID NO: 2 and SEQ ID NO: 3 respectively. The vaccine comprises the recombinant FCV antigen and a pharmaceutically acceptable carrier. The recombinant FCV antigen provided by the invention is easy for self-assembly to form a virus-like particle (VLP) with stable structure and excellent immunogenicity. The VLP has shape, stability and immunogenicity close to those of a wild virion, and can be prepared by large-scale serum-free suspension culture in a bioreactor through an insect cell expression system along with high expression level and good protein immunotherapy. The prepared vaccine is easy in quality control, stable in batches and low in production cost.

The invention discloses a preparation method of a homogeneous cyclic peptide Cyclo-(Ala)4. The preparation method comprises the steps: (1) allowing resin to react and be connected with alanine with aprotecting group to form resin connected with alanine, (2) conducting continuous condensation on alanine connected with the resin and alanine with the protecting group to form resin connected with a linear chain peptide, (3) cutting the linear chain peptide from the resin for end-to-end cyclization to form a cyclic peptide crude product, and (4) purifying and storing the cyclic peptide. Cyclo-(Ala)4 prepared by the method is in a homogeneous cyclic peptide structure formed by single amino acid, has a structure extremely similar to that of a crown ether compound; molecules having good regularity and multidirectional symmetry in structure can be self-assembled into an ion channel or a nano tube more easily as a drug carrier, a membrane channel, a molecular element and the like; no free aminogroup or carboxyl group is available in the molecules of the cyclic peptide, so that the cyclic peptide has extremely good liposolubility and biological in-vivo stability; at the same time, the method is reasonable in technology and simple in operation; the synthesis efficiency is higher.

The invention discloses a preparation method of ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under urea action. The preparation method comprises the following steps: adding solublesalt ferric trichloride, sodium chloride and urea of certain amount into absolute ethyl alcohol and deionized water to obtain suspension A; pouring the suspension A into a homogeneous-phase hydrothermal reaction kettle, and sealing the reaction kettle; putting the reaction kettle in a homogeneous-phase hydrothermal reaction instrument for a hydrothermal reaction; then naturally cooling to room temperature to obtain a product B; washing the product B with water and alcohol respectively, and dispersing the washed product in water to obtain a product C; performing freeze drying on the product C to obtain the ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under urea action. Through the homogeneous-phase hydrothermal process, the preparation method disclosed by the invention has the advantages of simplicity, short time, low cost and easiness in implementation; with a larger specific surface area, the ultra-fine Beta-FeOOH nanorod self-assembly hollow microspheres under ureaaction can provide more electrochemical reaction active sites to improve the reaction activity of a Beta-FeOOH conversion reaction.

The invention discloses a tool for installing and fixing a valve seat of a valve. The tool includes a butterfly screw (1), a gasket cover (2), a round nut (3), a steel pipe (4), a pull rod (5), an elastic sleeve ( 6) and the cone (7), one end of the tie rod (5) is screwed to the center of the cone (7), the cone (7) is inserted into the elastic sleeve (6), and one end of the steel pipe (4) is connected to the elastic sleeve (6) ), the round nut (3) is screwed on the external thread of the steel pipe (4), the other end of the steel pipe (4) is covered with the gasket cover (2), and the other end of the tie rod (5) protrudes from the gasket cover (2) And screw on thumb screw (1), integrally constitutes tool. The invention has the advantages of simple structure, easy understanding and convenient operation, thereby greatly improving the assembly efficiency of the valve.

The invention discloses a preparation method of homocyclic peptide Cyclo-[(Asp)5-Gly]. The method includes: (1) connection of resin with protective group equipped aspartic acid to form aspartic acid connected resin; (2) sequential condensation of the aspartic acid connected to resin with the protective group equipped aspartic acid and allylglycine to form linear peptide connected resin; (3) cutting of the linear peptide off the resin and end-to-end cyclization to obtain a cyclic peptide crude product; and (4) purification and preservation of cyclic peptide. The Cyclo-[(Asp)5-Gly] prepared by the invention is a homocyclic peptide structure, has a molecular structure with better regularity, is easier for self-assembly into an ion channel or nanotube, thus serving as a drug carrier, membrane channel, molecular device and the like. The five carboxyl functional groups contained on a side chain endow the product with certain water solubility and bioactivity, also an allyl functional group contained on the side chain endows the product with better reaction activity, so that the product can be used as a precursor reagent for high efficient click reaction. At the same time, the method has the advantages of reasonable process, simple operation, and high synthesis efficiency.

The invention relates to a laser nano material processing method and a processing system. The processing system includes a laser, a beam shaping module, a target module and a monitoring module, and a target seat located at the liquid interface is set, so that the laser enters and ablates different targets in different environments from the liquid interface. The interface is very close, so it can be easily self-assembled at the interface, and the target can be self-assembled at the interface to obtain a single-layer film. This preparation method has good controllability, and is more energy-saving, environmentally friendly and pollution-free than the chemical preparation method; use Transmittance monitoring indirectly monitors the self-assembly process of the liquid interface, with good accuracy and low monitoring cost; the device and method of the present invention are suitable for preparing nanometer single-layer film structures of various components, and can be widely used in various scientific research laboratories.

The invention relates to a method for guiding the self-assembly of polymer-modified carbon nanotubes in water through temperature regulation. Adsorb the polymer to the surface of the carbon nanotubes, then disperse the carbon nanotubes with the adsorbed polymers in water, change the temperature to make the carbon nanotubes self-assemble in the solvent, and separate the self-assembled carbon nanotubes by standing or centrifuging . The self-assembled body is a regular carbon nanotube bundle, which is composed of tens to thousands of highly oriented carbon nanotubes closely arranged in parallel. Self-assembly can concentrate and amplify the excellent performance of carbon nanotubes in the axial direction, so that carbon nanotubes have broader application prospects. The invention has simple steps and is easy to realize, self-assembly is carried out in water, no toxic organic solvent is used, and the invention is more environmentally friendly.

The invention relates to self-assembly systems formed by diphenol compounds and 2-formylbenzeneboronic acid and an application of the self-assembly systems as a fluorescence probe. According to the invention, two diphenol compounds respectively form the self-assembly systems with the 2-formylbenzeneboronic acid, the self-assembly systems can be taken as the fluorescence probe, the self-assembly systems are formed by adding the diphenol compounds and 2-formylbenzeneboronic acid in a phosphoric acid buffer, quantitative determination is carried out on free radical hypochloric acid and peroxynitrite, the probe has the advantages that the self fluorescence is weak, the fluorescence is obviously enhanced after effecting with a to-be-measured object, and compared with other detection free radical fluorescence quenching-type probes, the fluorescence probe has the characteristics of higher signal to noise ratio, rapidity, sensitivity, simpleness, and high efficiency.

The invention discloses a preparation method of a thermo-sensitive fluorescent polymer. The preparation method comprises the following steps: (1) synthesizing an NMA (N-alpha-naphthyl methacrylamide) monomer; (2) synthesizing a P(St-co-NMA)m (poly(styrene-co-NMA) macromolecular chain transfer agent; (3) synthesizing P(St-co-NMA)m-b-PENGMAn (P(St-co-NMA)m-b-poly(polyethylene glycol methacrylate)), namely the thermo-sensitive fluorescent polymer. According to the preparation method, the prepared nanoparticles simultaneously have thermosensitivity and fluorescence, and a series of fluorescent nanoparticles with different particle sizes can be prepared by changing external conditions.

The invention discloses phosphorylcholine polyethylene glycol modified chitosan and a preparation method thereof. The number-average molecular weight of the phosphorylcholine polyethylene glycol modified chitosan is 0.13 to 0.41 million, and the chemical structural formula of the phosphorylcholine polyethylene glycol modified chitosan is as shown in the description, wherein PC is as shown in the description, and n is equal to 4 to 50. The preparation method comprises the step of adopting chitosan and acrylate-terminated phosphorylcholine polyethylene glycol to carry out free radical polymerization so as to obtain the phosphorylcholine polyethylene glycol modified chitosan. The phosphorylcholine polyethylene glycol is introduced onto the chitosan, other reagents do not need to be introduced, a nanoparticle structure with a chitosan chain segment as a core and the phosphorylcholine polyethylene glycol on the surface can be self-assembled in water, meanwhile, the introduced phosphorylcholine polyethylene glycol chain segment has good water solubility, biocompatibility and flexibility, and phosphorylcholine radical is positioned at the tail end of the flexible polyethylene glycol, so that a simulated cell outer layer membrane structure is self-assembled more easily.

The invention discloses a preparation method of a magnetic molecular imprinting photonic crystal sensor for detecting melamine and belongs to the technical field of molecular imprinting photonic crystal and analysis detection. The product is obtained through preparation of oleic acid modified ferroferric oxide magnetic nanoparticles, preparation of melamine magnetic molecular imprinting nanoparticles and preparation of the magnetic molecular imprinting photonic crystal sensor. The melamine magnetic molecular imprinting nanoparticles are self-assembled to form a photonic crystal structure under the action of an external magnetic field, and a liquid-state molecular imprinting photonic crystal sensor is obtained. On a macro level, with increase of the concentration of melamine, the diffraction color of the sensor changes from weak purple to green, yellow and finally orange red. The preparation method has the advantages that the photonic crystals are assembled rapidly, simply and conveniently. The provided molecular imprinting photonic crystal sensor transmits a chemical signal of melamine concentration change directly through an optical signal of diffraction color change and realizes the purpose of naked eye detection.

The invention discloses a method for manufacturing a surface plasmon resonator chip based on lysine modification and mucoprotein modification. The chip comprises a BK7 glass sheet substrate, the BK7 glass sheet substrate is plated with a chromium layer of 2 nm to 3 nm and a gold film layer of 47 nm to 48 nm, amphipathic mucoprotein is connected to the surface of the gold film through hydrophobic groups of a protein framework, carboxyl groups of sugar residues on mucoprotein side chains are activated through 1-(3-dimethylamino propyl)-3-EDAC and N-hydroxysuccinimide and used for being coupled with lysine, and therefore the mucoprotein surface plasmon resonator chip based on lysine modification is obtained. The chip manufactured through the method has the high antifouling property in a single protein system and a complex system with the pH equal to 7.4 and can be easily assembled on various surfaces, and a stable and regular monomolecular layer is formed. The chip has the excellent antifouling property and high stability, the preparation method is relatively easy and convenient, and high feasibility and universality are achieved.

The invention discloses a preparation method of homocyclic peptide Cyclo-[(Asn)5-Cys]. The method includes: (1) connection of resin with protective group equipped asparagine to form asparagine connected resin; (2) sequential condensation of the asparagine connected to resin with the protective group equipped asparagine and cysteine to form linear peptide connected resin; (3) cutting of the linear peptide off the resin and end-to-end cyclization to obtain a cyclic peptide crude product; and (4) purification and preservation of cyclic peptide. The Cyclo-[(Asn)5-Cys] provided by the invention is a homocyclic peptide structure, has a similar structure to crown ether compounds, and compared with the heterocyclic peptide, has better regularity in terms of molecule structure, is easier for self-assembly into an ion channel or nanotube, thus serving as a drug carrier, membrane channel, molecular device and the like. The five amino functional groups contained on a side chain endow the product with certain water solubility and bioactivity, and a mercapto functional group contained on the side chain endows the product with better reaction activity, so that the product can be used as a precursor reagent for high efficient click reaction.

The invention discloses a preparation method of a homogeneous cyclic peptide Cyclo-(Ala)4. The preparation method comprises the steps: (1) allowing resin to react and be connected with alanine with aprotecting group to form resin connected with alanine, (2) conducting continuous condensation on alanine connected with the resin and alanine with the protecting group to form resin connected with a linear chain peptide, (3) cutting the linear chain peptide from the resin for end-to-end cyclization to form a cyclic peptide crude product, and (4) purifying and storing the cyclic peptide. Cyclo-(Ala)4 prepared by the method is in a homogeneous cyclic peptide structure formed by single amino acid, has a structure extremely similar to that of a crown ether compound; molecules having good regularity and multidirectional symmetry in structure can be self-assembled into an ion channel or a nano tube more easily as a drug carrier, a membrane channel, a molecular element and the like; no free aminogroup or carboxyl group is available in the molecules of the cyclic peptide, so that the cyclic peptide has extremely good liposolubility and biological in-vivo stability; at the same time, the method is reasonable in technology and simple in operation; the synthesis efficiency is higher.