35results about How to "Easy self-assembly" patented technology

The invention discloses a preparation method of a homogeneous cyclic peptide Cyclo-(Ala)4. The preparation method comprises the steps: (1) allowing resin to react and be connected with alanine with aprotecting group to form resin connected with alanine, (2) conducting continuous condensation on alanine connected with the resin and alanine with the protecting group to form resin connected with a linear chain peptide, (3) cutting the linear chain peptide from the resin for end-to-end cyclization to form a cyclic peptide crude product, and (4) purifying and storing the cyclic peptide. Cyclo-(Ala)4 prepared by the method is in a homogeneous cyclic peptide structure formed by single amino acid, has a structure extremely similar to that of a crown ether compound; molecules having good regularity and multidirectional symmetry in structure can be self-assembled into an ion channel or a nano tube more easily as a drug carrier, a membrane channel, a molecular element and the like; no free aminogroup or carboxyl group is available in the molecules of the cyclic peptide, so that the cyclic peptide has extremely good liposolubility and biological in-vivo stability; at the same time, the method is reasonable in technology and simple in operation; the synthesis efficiency is higher.

The invention provides glycosyl polyethers, a preparation method thereof and use thereof. In the method, macromolecular glycosyl polyethers which have a molecular weight ranging from several hundred to more than 100,000 and have a structure below are prepared by starting from common glycosyl donors and by a method of using the glycosyls as starting ends, bonding the glycosyls with the open-loop long chains of alkylene oxide at anomeric positions and using common nucleopilic reagents such as hydroxys, alkoxys, aminos, nitrines and halogen atoms as capping ends. As the mechanical performance and plasticity of the glycosyl polyether compounds can be controlled conveniently by regulating the length of the polyether chain, the glycosyl polyether compounds can be used as medical materials, important materials for synthesizing polyurethane, thermoplastic polyester-polyamide elastic materials and precursors for preparing glyconanoparticles.

The invention relates to a laser nano material processing method and a processing system. The processing system includes a laser, a beam shaping module, a target module and a monitoring module, and a target seat located at the liquid interface is set, so that the laser enters and ablates different targets in different environments from the liquid interface. The interface is very close, so it can be easily self-assembled at the interface, and the target can be self-assembled at the interface to obtain a single-layer film. This preparation method has good controllability, and is more energy-saving, environmentally friendly and pollution-free than the chemical preparation method; use Transmittance monitoring indirectly monitors the self-assembly process of the liquid interface, with good accuracy and low monitoring cost; the device and method of the present invention are suitable for preparing nanometer single-layer film structures of various components, and can be widely used in various scientific research laboratories.

The invention relates to self-assembly systems formed by diphenol compounds and 2-formylbenzeneboronic acid and an application of the self-assembly systems as a fluorescence probe. According to the invention, two diphenol compounds respectively form the self-assembly systems with the 2-formylbenzeneboronic acid, the self-assembly systems can be taken as the fluorescence probe, the self-assembly systems are formed by adding the diphenol compounds and 2-formylbenzeneboronic acid in a phosphoric acid buffer, quantitative determination is carried out on free radical hypochloric acid and peroxynitrite, the probe has the advantages that the self fluorescence is weak, the fluorescence is obviously enhanced after effecting with a to-be-measured object, and compared with other detection free radical fluorescence quenching-type probes, the fluorescence probe has the characteristics of higher signal to noise ratio, rapidity, sensitivity, simpleness, and high efficiency.