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Construction method of drug sustained release system on medical titanium alloy implant surface

A construction method and implant technology, which is applied in the field of construction of drug sustained-release system on the surface of medical titanium alloy implants, can solve the problems of decreased immunity at the tissue interface, secondary trauma of patients, and susceptibility to infection, etc. Effects of shedding, increased drug loading, and good biocompatibility

Active Publication Date: 2018-09-14
TONGREN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, titanium alloy materials have been widely used in artificial joints, internal fixation of fractures, spinal orthopedics, and fusion fixation materials. However, due to the implantation of titanium alloys, the immunity of the tissue interface is reduced, which makes it easy for the implant to enter the human body. Infection, bacteria will adhere to the surface of the implant and multiply rapidly, forming a dense biofilm on the surface of the implant. Conventional antibiotic therapy is difficult to enter the surface of the implant through the human body to kill the bacteria , it often requires multiple debridement operations to make up for not only the increased cost but also the secondary trauma to the patient

Method used

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  • Construction method of drug sustained release system on medical titanium alloy implant surface
  • Construction method of drug sustained release system on medical titanium alloy implant surface
  • Construction method of drug sustained release system on medical titanium alloy implant surface

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0035] Construction of nanospheres with anti-inflammatory effects

[0036] In the case of mycobacterial infection on the surface of the implant material, streptomycin sulfate was selected as an antibacterial substance and assembled on the surface of the titanium alloy. Streptomycin sulfate has a strong antibacterial effect on Mycobacterium tuberculosis. In this experiment, MPLA microspheres containing streptomycin sulfate were prepared by self-assembly into spheres, and the coverage rate of MPLA microspheres for streptomycin sulfate was determined by ultraviolet absorption spectroscopy.

[0037] 1. Experimental materials

[0038] D, L-polylactic acid, maleic anhydride (MA analytical pure Chongqing Chuandong Chemical Co., Ltd.), dibenzoyl peroxide (BPO analytical pure Chongqing Chuandong Chemical Co., Ltd.), deionized water, dichloromethane (analytical pure Chengdu Kelong Chemical Reagent Factory), chloroform (analytical pure Chengdu Kelong Chemical Reagent Factory), ether (a...

specific Embodiment 2

[0053] Construction of SS-MPLA / PEI Multilayer Film on Titanium Surface

[0054] To sum up, in this experiment, titanium alloy was used as the base material, and the surface of the titanium alloy was aminated through surface graft modification. The surface of the material has more positively charged groups, which is more conducive to the later layer-by-layer self-assembly steps. Through layer-by-layer self-assembly technology, a multi-layer film was constructed on the surface of titanium amide, and a sustained-release system for antibacterial drug streptomycin sulfate was established. MPLA microspheres and PEI were used as polyanions and cations, respectively, and electrostatic adsorption was used to achieve SS-MPLA microspheres. Ball / PEI multilayer film, the formation of multilayer film can be judged indirectly by contact angle. figure 2 It is a schematic diagram of titanium surface amination and further layer-by-layer self-assembly process.

[0055] 1. Experimental materia...

specific Embodiment 3

[0075] Verification of sustained release effect of antibacterial film on titanium alloy surface

[0076] 1. Experimental materials

[0077] The surface NH 2 / (SS-MPLA / PEI) 5 ; NH 2 / (SS-MPLA / PEI) 10 Multilayer film; phosphate buffered saline (PBS, 0.1M, pH=7.4): ferric ammonium sulfate ((NH 4 ) 2 SO 4 · Fe 2 (SO 4 ) 3 24 hours 2 O analytically pure Chongqing Chuandong Chemical Co., Ltd.); sodium hydroxide (analytical pure Chongqing Chuandong Chemical Co., Ltd.); concentrated sulfuric acid (analytical pure Chongqing Chuandong Chemical Co., Ltd.); deionized water.

[0078] 2. Experimental method

[0079] 5 NH prepared by the method of the above-mentioned specific example two 2 / (SS-MPLA / PEI) 5 Titanium sheet, 5 NH 2 / (SS-MPLA / PEI) 5 Put the titanium sheets into the cell culture dishes respectively, add 3ml of 0.1M phosphate buffer (pH=7.4) to the 10 cell culture dishes, cover and seal, and place at room temperature; at 1, 3, 6, 12, During the period of 24, 36, 48...

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Abstract

The invention discloses a method for constructing a slow release system for medicament on surface of a medical titanium alloy implant. The system is characterized in that the method comprises the following steps: a solvent blending method is used for grafting maleic anhydride to polylactic acid in order to prepare maleic anhydride grafted polylactic acid; MPLA microballoons containing streptomycin sulphate is prepared by a self-assembly balling method; surface amination of titanium alloy is carried out by surface grafting modification, so that the surface of titanium has positive charges, a layer by layer assembly technology is used, the MPLA microballoons and PEI are used as negative and positive ions respectively, static adsorption is used, and an SS-MPLA microballoon / PEI multilayer antibacterial film is constructed on the surface of the titanium material. When the multilayer antibacterial film on the surface of the implant in vivo is degraded, streptomycin sulphate is slowly released, so that long-term bacteriostasis effect is realized, and the system has the effects of good compatibility, high stability, firm combination, and long slow release time.

Description

technical field [0001] The invention relates to a medical titanium alloy implant, in particular to a method for constructing a drug sustained release system on the surface of the medical titanium alloy implant. Background technique [0002] Biomedical materials (biomedical materials) are materials that diagnose, treat or replace tissues and organs in living organisms, or enhance the corresponding functions of tissues and organs, and have no adverse effects on the human body. Biomedical materials can be natural, such as biologically active cells, tissues, and organs, or synthetic, such as polymer materials, ceramics and carbon materials, artificial synthetic materials, or metal and alloy materials. It can also be a composite of natural materials and synthetic materials, such as the assembly of living cells on synthetic materials to become implants with therapeutic effects. Due to the formation of stable TiO on the surface of titanium and titanium alloys 2 Membrane, with its...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/54A61L31/12A61L31/16
CPCA61L27/34A61L27/54A61L31/10A61L31/16A61L2300/232A61L2300/406A61L2300/602A61L2300/608A61L2300/62A61L2300/802A61L2400/18C08L79/02C08L67/04
Inventor 黄啸郑曦
Owner TONGREN UNIV
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