Chirality anona squamosa L. lactone compound with conformation limitation structure and synthesizing method and use thereof

A technique of constraining the structure of anemone lactone, which is applied in the field of chiral anemone lactone analogues and their synthesis, and can solve the problems of not obtaining chiral products, etc.
CN101108840BInactive Publication Date: 2013-06-05SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Publication Date
2013-06-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the chemical compound of the chiral annonaceous acetogenins of the comformational restriction structure, the synthetic method and the purpose. The compound has the optical activity compound as the above formula: (R or S configuration) (R or S configuration). The compound of the invention has high anti-cancer activity and selectivity and has the IC50 (MuM) of the human breast duct cancer reaching less than 0.04, and the suppressive activity on the cancer cell is about 100 times that of the normal cell and has better selectivity. The compound of the invention can also be used as the anti-cancer drug and has simple preparation method, which is a method suitable for the industrial production.
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Description

technical field

[0001] The present invention relates to a lactone compound, in particular to a chiral anemone lactone analogue and its synthesis method and application. Background technique

[0002] Currently, cancer has become the greatest threat to human health, and its incidence is increasing year by year. Cancer is responsible for more than 20% of all deaths each year, a figure that exceeds the combined number of deaths from AIDS, tuberculosis and malaria. Traditional cancer treatment methods, such as surgical resection, radiotherapy and chemotherapy, have certain defects, either incomplete treatment or severe side effects. With the development of modern organic separation identification and synthesis technology, many chemists are committed to the separation and identification of natural compounds with high anti-tumor activity and selectivity from natural products, and obtain this natural compound with relatively high content through organic synthesis. Low compounds, a...

Claims

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