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Highly effective abstraction method for preparation of high-purity ginko flavonoid

A high-purity technology for ginkgo flavonoids is applied in the field of efficient preparation for extracting high-purity ginkgo flavonoids, which can solve the problems of low extract content, complex process, low extraction yield, etc. Easy control and high extraction rate

Inactive Publication Date: 2008-03-05
颜廷和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Representative is the preparation of Ginkgo biloba extract by solvent extraction, such as Sehwabe in Germany, Flaschman pharmaceutical factory, mainly dry coarse powder of Ginkgo biloba, 60% acetone extraction, pressure filtration with carbon tetrachloride degreasing, acetone water The layer is saturated with ammonium sulfate, extracted with methyl ethyl ketone, the extract is concentrated under reduced pressure to form an ethanol solution of a certain concentration, added with an appropriate amount of lead hydroxide for filtration, the filtrate is concentrated and then saturated with ammonium sulfate, extracted with methyl ethyl ketone, and the extract is dried and concentrated Ginkgo biloba extract is obtained by refining with ethanol and then concentrating and drying. This method uses many organic and inorganic chemical media, the process is complicated, the cost is high, and it is easy to cause residues to affect product quality.
At present, the production technology of ginkgo biloba extract in China mostly uses water or alcohol solvent to extract, and then adsorbed by macroporous resin, but the extraction rate is low and the content of the extract is not high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A, adopt the ginkgo leaves when the autumn leaves are not yellow, dry at a temperature of 120°C, and store after drying;

[0025] B, Ginkgo biloba is pulverized, and pulverized particle size is 4 millimeters, for subsequent use;

[0026] C, extract with 80% ethanol solution, temperature control is normal temperature during extraction;

[0027] D. Concentrate the extract to recover ethanol, and the temperature during concentration is not higher than 65°C;

[0028] E. Dilute the concentrated solution with water or purified water, cool and settle, and control the temperature of the cold sink at 10°C.

[0029] F, supernatant enters styrene type macroporous resin adsorption column (such as DM-130) to adsorb;

[0030] G, eluting with alcohol solution, the concentration of eluent is 70%;

[0031] H. Concentrate the eluate under reduced pressure at a concentration temperature of 60-70°C, vacuum-dry at a drying temperature of 60-70°C, crush and pack.

Embodiment 2

[0033] A, adopt the ginkgo leaves when the autumn leaves are not yellow, dry at a temperature of 85°C, and store after drying;

[0034] B, the Ginkgo biloba is pulverized, and the pulverized particle size is 3 millimeters for subsequent use;

[0035] C, extract with 70% ethanol, temperature is controlled at 50 ℃ during extraction;

[0036] D, the extract is concentrated to recover ethanol, and the temperature during concentration is 75°C;

[0037] E. Dilute the concentrated solution with water or purified water, cool and settle, and control the cooling temperature at 15°C;

[0038] F, clear liquid enters styrene type macroporous resin adsorption column (such as D 101) to adsorb;

[0039] G, desorb with alcohols, the concentration of the desorption solution that is alcohol is 80%;

[0040] H. Concentrate the eluate under reduced pressure at 60-70° C., dry it in vacuum, crush it and pack it.

Embodiment 3

[0042] A, adopt the ginkgo leaves when the leaves are not yellow in autumn, dry them at a temperature of 160°C, and store them after drying;

[0043] B, Ginkgo biloba is pulverized, and the pulverized granularity is 5 millimeters, for subsequent use;

[0044] C, extract with 50% ethanol, temperature is controlled at 50 ℃ during extraction;

[0045] D, the extract is concentrated to recover ethanol, and the temperature during concentration is 60°C;

[0046] E. Dilute the concentrated solution with water or purified water, cool and settle, and control the cooling temperature at 5°C:

[0047] F, clear liquid enters styrene type macroporous resin adsorption column (D 201) to adsorb;

[0048] G, desorb with alcohols, the concentration of the desorbing solution that is alcohol is 90%;

[0049] H. Concentrate the eluate under reduced pressure at 60° C., dry it in vacuum, crush it and pack it.

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PUM

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Abstract

The present invention is high efficiency extracting process of high purity gingko flavone compound, and belongs to the field of natural plant medicine extracting technology. The extracting process includes the following steps: collecting green gingko leaf in autumn and stoving, crushing, extracting with 50-90 % concentration alcohol solution, concentrating the extracted solution to recover alcohol, diluting the concentrate and cooling to precipitate, adsorbing the supernatant with macroporous resin, desorbing with alcohol, vacuum concentrating the eluted solution, vacuum drying, crushing and packing. The process has no harmful matter residue, simple control and high extracting rate, and product has high effective component content and stable quality.

Description

(1) Technical field [0001] The invention relates to a natural plant drug extraction technology, in particular to a high-efficiency preparation method for extracting high-purity ginkgo flavonoids from ginkgo leaves as raw materials. (2) Background technology [0002] Ginkgo biloba is one of the oldest tree species in the world and is known as a "living fossil". Ginkgo biloba is an important medicinal and health food raw material. Its extract has a strong antioxidant effect. Modern medical science research shows that, Ginkgo flavonoid glycosides, ginkgolides and bilobalides are the main components of ginkgo biloba extract, they have the functions of capturing free radicals, inhibiting platelet activating factor (PAF), promoting blood circulation and brain metabolism, etc. Blood pressure, hypotension, heart disease, arteriosclerosis, hypofunction of the brain and other diseases have a good preventive effect. In recent years, domestic and foreign countries, especially Germany, ...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07D493/14C07D493/22A61K36/16A61K127/00
Inventor 颜廷和
Owner 颜廷和
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