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Nanometer bacteria cellulose aldehyde grouping modified method

A bacterial cellulose and nano-bacteria technology, applied in microorganism-based methods, biochemical equipment and methods, microorganisms, etc., can solve the problems of low performance of bacterial cellulose and cells, and achieve improved reactivity and cell adhesion, The effect of expanding the application field

Inactive Publication Date: 2008-05-21
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although bacterial cellulose (3-10nm) has a natural and fine network structure, excellent mechanical properties and biocompatibility, the adhesion of bacterial cellulose to cells and the performance of drug loading are not outstanding.

Method used

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  • Nanometer bacteria cellulose aldehyde grouping modified method

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example 1

[0027] Using Acetobacter xylinum as a bioreactor, a milky white bacterial cellulose hydrogel film was prepared by fermentation [L.Hong, Y.L.Wang, S.R.Jia, Y.Huang, C.Gao, Y.Z.Wan Hydroxyapatite / bacterialcellulose composites synthesized via a biomimetic route, Materials Letters 60(2006) 1710-1713.]. The strains of Acetobacter xylinum were placed in agar solid medium and kept refrigerated at 4°C.

[0028] Suspend 50 g of bacterial cellulose produced by Acetobacter xylinum in deionized water, add 0.1 g of 2,2,6,6-tetramethylpiperidine oxide and 1.3 g of sodium bromide, and stir thoroughly. Then slowly add 0.25 g of sodium hypochlorite solution with 10% available chlorine, and add 0.5 M sodium hydroxide solution to adjust the pH of the system to 11. Start timing, and after reacting at 25° C. for 30 min, add 40 ml of absolute ethanol to terminate the reaction. After the bacterial cellulose is taken out and rinsed repeatedly with deionization, the aldylated bacterial cellulose is ...

example 2

[0036] Suspend 50 g of bacterial cellulose produced by Acetobacter xylinum in deionized water, add 0.1 g of 2,2,6,6-tetramethylpiperidine oxide and 1.3 g of sodium bromide, and stir thoroughly. Then slowly add 0.5 g of sodium hypochlorite solution with 5% available chlorine, and add 0.5 M sodium hydroxide solution to adjust the pH of the system to 10. Start timing, and after reacting at 30° C. for 20 minutes, add 40 ml of absolute ethanol to terminate the reaction. After the bacterial cellulose is taken out and rinsed repeatedly with deionization, the aldylated bacterial cellulose is obtained. The evaluation method is the same as Example 1.

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Abstract

The invention relates to a method for modifying nano-bacillus fibrin aldehyde group. The method takes the nano-bacillus fibrin as the basic raw material and the nano-bacillus fibrin is provided with a fine three-dimensional network structure; the diameter of micro-fiber is 3 to 10nm; the nano-bacillus fibrin is suspended in deionized water and oxidant is added into the deionized water; the oxidant is 2,2,6,6- Tetramethylpiperidinooxy, sodium bromide and sodium hypochlorite; the reaction is implemented for 20 to 40 min under an alkaline environment with a temperature of 20 to 30 Celsius degrees and the pH value of the alkaline solution is 10 to 12. The invention can prepare nano-bacillus fibrin which contains aldehyde group under very moderate conditions and can greatly enlarge the application field of the nano-bacillus fibrin.

Description

technical field [0001] The invention relates to a method for formaldehyde modification of nano-bacteria cellulose, which belongs to the research category of nano-biological materials. Background technique [0002] Cellulose is a kind of polymer hydrogel material, and it is the most abundant biomacromolecule on the earth. It can be divided into plant cellulose and nanocellulose, among which plant cellulose is the most important component of plants. ; Bacterial cellulose is a representative of microbial extracellular macromolecules and is a specific product of primary metabolism. The biggest difference between bacterial cellulose and plant cellulose lies in its chemical purity. The former is a pure cellulose, while the latter is usually connected with hemicellulose and lignin that are difficult to remove. Bacterial cellulose spontaneously forms a fine network structure in the medium, and this special structure determines the chemical and physical properties of cellulose. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/04C08B15/00C12R1/01C12R1/05C12R1/38C12R1/41
Inventor 万怡灶高川何芳黄远罗红林
Owner TIANJIN UNIV
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