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Lomoxicam sustained release tablet and preparation method thereof

A technology for lornoxicam and sustained-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problem of large fluctuations in the blood concentration of lornoxicam, inconvenient clinical medication for patients, and easy occurrence of Adverse reactions and other problems, to achieve the effect of reducing the incidence of adverse reactions, reducing the fluctuation of blood drug concentration, and improving convenience

Active Publication Date: 2008-05-28
ZHEJIANG ZHENYUAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Lornoxicam has a good analgesic and anti-inflammatory effect, but due to its short half-life in vivo, in order to maintain the effective blood concentration, clinical oral lornoxicam ordinary tablets often need repeated medication, and each time you need to take multiple tablets. Inconvenience to clinical medication for patients
At the same time, the plasma concentration of lornoxicam fluctuates greatly and adverse reactions are prone to occur, and its action time is relatively short.

Method used

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  • Lomoxicam sustained release tablet and preparation method thereof
  • Lomoxicam sustained release tablet and preparation method thereof
  • Lomoxicam sustained release tablet and preparation method thereof

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preparation example Construction

[0076] The preferred preparation method of lornoxicam sustained-release preparation of the present invention comprises the following steps:

[0077] (i) Mix 2.0-60.00 parts by weight of lornoxicam, 10.00-95.00 parts by weight of slow-release retarding materials and fillers, add binders, and make soft materials; wherein, the slow-release retarding materials include : Hypromellose or a mixture of hydroxypropylmethylcellulose and other celluloses;

[0078] (ii) granulating, drying, sizing, drying and tableting the soft material to obtain lornoxicam sustained-release tablets.

[0079] Any method known in the field of formulation can be used to carry out the steps of mixing, preparing the soft material, and granulating, drying, sizing, drying or tableting the soft material.

[0080] Other sustained-release tablet preparation methods known in the art can also be used to prepare the lornoxicam sustained-release preparation of the present invention. For example, dry granulation tabl...

Embodiment 1

[0095] Preparation of Lornoxicam Sustained Release Tablet 1

[0096] 1000 pieces

[0097] Lornoxicam 12g

[0098] Hypromellose (viscosity: 4000 centipoise) 15g

[0099] Hypromellose (viscosity: 100 centipoise) 30g

[0100] Lactose 150g

[0101] Magnesium Stearate 1g

[0102]

[0103] Total weight 208g

[0104] Preparation:

[0105] Grind lornoxicam, hypromellose (viscosity: 4000 centipoise), hypromellose (viscosity: 100 centipoise) and lactose, pass through a 100-mesh sieve, and mix mechanically. Add 5% povidone aqueous solution (g / 100 ml, model: K30) to granulate during stirring, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 lornoxicam sustained-release tablets 1.

Embodiment 2

[0107] Preparation of Lornoxicam Sustained Release Tablet 2

[0108] 1000 pieces

[0109] Lornoxicam 8g

[0110] Hypromellose (viscosity: 4000 centipoise) 15g

[0111] Hypromellose (viscosity: 50 centipoise) 15g

[0112] Ethyl cellulose (viscosity: 20 centipoise) 15g

[0113] Lactose 150g

[0114] Magnesium Stearate 1g

[0115]

[0116] Total weight 204g

[0117] Preparation:

[0118] Grinding lornoxicam, hypromellose (viscosity: 4000 centipoise), hypromellose (viscosity: 50 centipoise), ethyl cellulose (viscosity: 20 centipoise), lactose, 100 mesh sieve, mechanically mixed. During stirring, add 5% povidone (type: K30) aqueous solution to granulate, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 lornoxicam sustained-release tablets 2.

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Abstract

The invention provides a lornoxicam sustained release tablet and the preparation method thereof. The sustained release tablet includes 2.0-60.00 parts of lornoxicam by weight and 10.00-95.00 parts of sustained release block material by weight; wherein, the sustained release block material includes hydroxypropyl methyl cellulose or compound of hydroxypropyl methyl cellulose and other celluloses. The preparation method is that raw material prescription doses of lornoxicam, sustained release block material and filler are evenly mixed, then added with adhesive to be prepared into soft material; pelletization, drying and finishing granule are carried out according to the conventional technique of the tablet preparation, and the dry grain after finishing granule is added with lubricant, evenly mixed and pressed to make the preparation. Compared with conventional oral lornoxicam preparation, the lornoxicam sustained release tablet can maintain a longer effect after oral administration of the drug.

Description

technical field [0001] The invention relates to a sustained-release preparation of non-steroidal anti-inflammatory drugs and a preparation method thereof, in particular to lornoxicam sustained-release tablets and a preparation method thereof. Background technique [0002] Lornoxicam, the chemical name is 6-chloro-4-hydroxy-2-methyl-3-(2-pyridinecarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine -1,1-dioxide belongs to Oxycam non-steroidal anti-inflammatory analgesics. It has strong analgesic and anti-inflammatory effects, and can be used in obstetrics and gynecology, oral tooth extraction, orthopedic surgery and postoperative acute pain, moderate to severe pain caused by trauma, acute sciatica and low back pain, advanced cancer pain, and can also be used In the treatment of chronic low back pain, osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. [0003] Parenteral lornoxicam was as effective as morphine, meperidine, and tramadol in relieving postoperative pain, but l...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K31/542A61P29/00
Inventor 张建军俞建生高缘翁杭辉许梁
Owner ZHEJIANG ZHENYUAN PHARMA CO LTD
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