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Human body hard tissue filling renovation material containing calcium citrate

A technology of calcium citrate and repair materials, which is applied in the fields of prosthesis, medical science, organic chemistry, etc. It can solve the problems of affecting the formation of new bone tissue, difficult biodegradation or absorption, application restrictions, etc., and achieve good bone conduction and repair effects , good biocompatibility, and wide application value

Inactive Publication Date: 2008-05-28
彭磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biomaterials based on hydroxyapatite and tricalcium phosphate are still difficult to completely biodegrade or absorb in the bone defect after a long period of time, eventually affecting the formation of new bone tissue; bone filling materials based on calcium sulfate hemihydrate, due to The price is expensive, its degradation speed is too fast, and the calcium concentration around the material is 14mmol / L, which eventually affects the proliferation and mineralization of surrounding osteoblasts; although bioglass has a certain bone activation effect, it has high brittleness and low bending strength, etc. insufficient
The application of these materials is limited due to their own defects

Method used

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  • Human body hard tissue filling renovation material containing calcium citrate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prepare tricalcium citrate according to the literature method (Wang Shanyang, Weng Zhenhui, He Yanhong. Prepare calcium citrate from shells [J]. Journal of Hangzhou Normal University, 1995 (6): 69-73), or pharmaceutical grades available on the market Tricalcium citrate is the main raw material (100%), which is granulated, dried, and prepared into lumps with a tablet press under a pressure of 6 mPA at normal temperature.

[0020] The use effect verification experiment is as follows:

[0021] cobalt 60 After disinfection, it was co-incubated with rabbit osteoblasts in vitro, cell proliferation and differentiation were observed at 7 days, and the relative cell proliferation rate (RGR) was calculated. Calculation formula: RGR=(test group X / negative control group X)×100%, according to the 6-level toxicity scoring standard, the material toxicity score is 1, without any cytotoxicity, and cells can adhere and proliferate on the surface of tricalcium citrate ( As shown in Figu...

Embodiment 2

[0023] Adopting tricalcium citrate as the main material (85%), after mixing with auxiliary materials fibrin glue (14.5%) and tetracycline (0.5%), through granulation, drying, under normal temperature, under the pressure of 10mPA, a tablet press is prepared into Blocks or flakes are prepared and shaped.

[0024] The use effect verification experiment is as follows:

[0025] cobalt 60 After disinfection, it was co-incubated with rabbit osteoblasts in vitro, cell proliferation and differentiation were observed at 7 days, and the relative cell proliferation rate (RGR) was calculated. Calculation formula: RGR=(test group X / negative control group X)×100%, according to the 6-level toxicity scoring standard, the material toxicity score is level 1, without any cytotoxicity. The material was implanted into the back muscle bag of rats in vivo, and histology confirmed that the biomaterial had no adverse reactions and had good biocompatibility; it was degradable and drug-sustained-releas...

Embodiment 3

[0027] Tricalcium citrate is used as the main material (65%), mixed with auxiliary materials polyvinylpyrrolidone (34.5%) and vancomycin (0.5%); after granulation, drying, and compression at room temperature under a pressure of 5mPA Machine prepared into blocks.

[0028] The use effect verification experiment is as follows:

[0029] cobalt 60 After disinfection, it was co-incubated with rabbit osteoblasts in vitro, cell proliferation and differentiation were observed at 7 days, and the relative cell proliferation rate (RGR) was calculated. Calculation formula: RGR=(test group X / negative control group X)×100%, according to the 6-level toxicity scoring standard, the material toxicity score is level 1, without any cytotoxicity. The material was implanted into the back muscle bag of rats in vivo, and histology confirmed that the biomaterial had no adverse reactions and had good biocompatibility; it was degradable and drug-sustained-release activity (degradation time in vivo was ...

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Abstract

The invention relates to a human hard tissue filling and repair material containing calcium citrate. The invention provides the human hard tissue filling and repair material containing calcium citrate, wherein the calcium citrate is selected from tricalcium citrate, which can be one or any combination of tricalcium citrate tetrahydrate (the molecular formula is Ca3(C6H5O7)2.4H2O), tricalcium citrate dihydrate (the molecular formula is Ca3(C6H5O7)2.2H2O) and tricalcium citrate anhydrous (the molecular formula is Ca3(C6H5O7)2), and the weight percentage content of which in the human hard tissue filling and repair material is 50 to 100 percent. The invention also provides the preparation method of the human hard tissue filling and repair material containing calcium citrate. The human hard tissue filling and repair material containing calcium citrate which is provided by the invention is a reliable hard tissue filling and repair material which is degradable in the body, and the invention has significant treatment effects to bone defects, osteoporosis and bone tumors.

Description

technical field [0001] The invention relates to a human body hard tissue filling repair material containing calcium citrate. Background technique [0002] Fractures and bone defects caused by various reasons are very common clinically, but the treatment effect is still unsatisfactory. In the past few decades, although many bone repair materials have been prepared, 70% of bone repair materials in clinical practice still use autologous bone or allogeneic bone. The effect of autologous bone transplantation is relatively reliable, but it increases surgical trauma and costs a lot, and patients often Unwilling to accept, and the sources of bone donors are limited. Allogeneic bone has the potential risk of spreading human diseases, and its source is also limited. Xenograft bone has strong immunogenicity and may cause the spread of zoonotic diseases, which has certain limitations; therefore, artificially prepared bone filling repair materials have a good application prospect. [...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/58A61L27/34C07C55/22
Inventor 彭磊
Owner 彭磊
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