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Preparation method for octacosanol

A technology of octacosanol and octacosanol, which is applied in the field of preparation of octacosanol, can solve the problems of not preparing octacosanol, achieve no environmental pollution, high conversion efficiency, and process route simple effect

Inactive Publication Date: 2008-05-28
广州伯凯生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, as of now, there is no report on the preparation of octacosanol from octacosanol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0021] Example 2 Put crude product 5g and 100mL methanol containing 40% octacosanol into a 1L reaction kettle, add 100mg8% palladium carbon catalyst, use 0.4Mpa hydrogen to blow 3 times, continue to maintain after removing the air in the still Introduce hydrogen, the pressure in the kettle is 4Mpa, under the stirring of 800 rpm, the temperature is raised to 120°C, after constant temperature, react for 5 hours, stop heating, cool to room temperature, adjust the exhaust valve to reduce the pressure, and measure the content by gas chromatography , the content of octacosanol is 1.5%, and the conversion rate of octacosanol is 96.25%.

Embodiment 3

[0022] Example 3 Put 5 g of the crude product containing 40% octacosanol and 200 mL of ethanol into a 1 L reaction kettle, add 50 mg of platinum catalyst, and purge 3 times with 0.4 Mpa hydrogen, and continue to maintain the ventilation after removing the air in the kettle. Enter hydrogen, the pressure in the kettle is 4Mpa, under the stirring of 1500 rpm, heat up to 120°C, after constant temperature, react for 4 hours, stop heating, cool to room temperature, adjust the exhaust valve to reduce the pressure, and measure the content by gas chromatography , the content of octacosanol is 0.87%, and the conversion rate of octacosanol is 97.8%.

example 4

[0023] Example 4 Put 5 g of crude product containing 40% octacosanol and 300 mL of propanol into a 1-liter reactor, add 300 mg of 20% palladium-carbon catalyst, and purse 3 times with 0.4 Mpa hydrogen, after removing the air in the still Continue to keep feeding hydrogen, the pressure in the kettle is 4Mpa, under the stirring of 2000 rpm, the temperature is raised to 110°C, after constant temperature, react for 1.5 hours, stop heating, cool to room temperature, adjust the exhaust valve to reduce the pressure, and use gas chromatography Determination of content by method, the content of octacosanol is 4.2%, and conversion rate is 89.5%.

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PUM

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Abstract

The invention relates to a preparation method of octacosanol: using octacosa-enol as raw materials; catalytic hydrogenation reaction is carried out in reaction solvent of lower alcohol containing one to six carbon atoms with precious metals catalyst of palladium and platinum; the reaction conditions are that: the temperature is 100 to 180 DEG C; the pressure is 3.0 to 6.0 MPa; the agitating speed is 600 to 1800 RPH, and the reaction time is 2.0 to 6.0 hours. The octacosa-enol can be changed into the octacosanol with conversion efficiency above 90 percent.

Description

technical field [0001] The invention relates to a method for preparing octacosanol, in particular to a method for preparing octacosanol from octacosanol. technical background [0002] Octacosanol is a high-level aliphatic alcohol, which has physiological functions such as promoting hormone action, reducing muscle pain, strengthening heart function and oxygen transport capacity, reducing systolic blood pressure, and improving basal metabolism. It can be used to treat hypercalcemia Osteoporosis, lower serum total cholesterol and triglyceride content, has obvious effect on lowering LDL cholesterol, is widely used in improving people's quality of life, enhancing people's vitality, losing weight and reducing fat, preventing coronary heart disease and other medical care field. [0003] Octacosanol is widely found in plant lipids. Octacosanol is contained in the epidermis of leaves, stems, and fruits of many plants, as well as food waxes such as apples, grapes, alfalfa, sugar can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C31/125C07C29/17
Inventor 吕扬效张雷李环王玉亭
Owner 广州伯凯生物技术有限公司
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