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Hydroxyl apatite/nylon nanometer artificial bone and preparing method thereof

A technology of hydroxyapatite and nano-hydroxyapatite, which is used in medical science, prosthesis, etc., can solve the problems of difficulty in meeting the requirements of medical materials, uneven dispersion, and low material purity.

Inactive Publication Date: 2008-06-18
SHANGHAI GENIUS ADVANCED MATERIAL (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The blending method is to melt and blend nylon 66 and nano-hydroxyapatite powder through a screw extruder and other equipment. It is difficult to achieve a high filling amount of hydroxyapatite in composite materials prepared by this method, and hydroxyapatite The stone particles are seriously agglomerated and dispersed unevenly in the composite material
The solution co-precipitation method is to dissolve nylon 66 in a solvent containing nano-hydroxyapatite, and then precipitate the composite material. Although this method can make the hydroxyapatite particles in the nano-scale and uniformly dispersed, the product performance is good, but in A large number of high-boiling solvents are used in the preparation process, which not only greatly increases the cost, but also the product contains solvents that are difficult to remove, and the purity of the material is low, which is difficult to meet the requirements of medical materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0050] The preparation method of the present invention is described below:

[0051] Preparation

[0052] The preparation method of the present invention includes the following steps:

[0053] (A) Provide an aqueous dispersion of hydroxyapatite and nylon salt;

[0054] Wherein the weight ratio of the hydroxyapatite to the nylon salt is (50-66): (34-50); the total content of the hydroxyapatite and the nylon salt is 60-80% by weight, calculated based on the total weight of the dispersion;

[0055] (B) The dispersion of the step (a) is polymerized in situ to obtain the artificial bone.

[0056] Specifically, for example: first prepare nano-hydroxyapatite by acid-base neutralization method, dissolve nylon salt in an aqueous solution of nano-hydroxyapatite, then boil off the water for concentration, and then carry out nylon salt in an autoclave The condensation polymerization.

[0057] Acid-base neutralization method

[0058] Preferably, the hydroxyapatite is prepared by an acid-base ...

Embodiment 1

[0080] Calcium hydroxide and phosphoric acid were mixed according to the molar ratio of 1.67, reacted in deionized water at 70°C for 48 hours, and then nylon 66 salt was added in the same amount as hydroxyapatite. The boiling water was removed and concentrated to a slurry containing 70% of the total material. Add the slurry to the reactor, gradually increase the temperature to 235°C, and control the pressure at 17.5MPa. After reacting for 3 hours, remove water under reduced pressure for 1 to 1.5 hours. After the pressure drops to normal pressure, increase the temperature to 280-290°C. React for 40-60 minutes under the condition of ~6KPa, and then discharge. The material can be molded or injection molded.

[0081] The size of hydroxyapatite in the composite material is as follows:

[0082] Shape

Needle

Average length

80nm

The average diameter

14nm

Aspect ratio

5.7

[0083] The properties of the composite material are as follow...

Embodiment 2

[0087] The implementation process is the same as in Example 1, and the compounding ratio of hydroxyapatite and nylon 66 salt is changed to 1.2 / 1.

[0088] The size of the hydroxyapatite in the composite is the same as in Example 1.

[0089] The properties of the composite material are as follows: the tensile strength is tested according to the ASTM D638 standard, and the flexural strength and flexural modulus are tested according to the ASTM D638 standard.

[0090] Nano-hydroxyapatite content

62％

Tensile Strength

76MPa

Bending strength

48MPa

Flexural modulus

6.5GPa

[0091] Other physical properties test

[0092] The obtained composite material is tested by transmission electron microscopy, and the hydroxyapatite is needle-shaped, with a length of less than 100 nm and a diameter of 10-20 nm, and is uniformly dispersed in the composite material without obvious agglomeration.

[0093] It is confirmed by photoelectron spectrosc...

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Abstract

The invention provides a hydroxyapatite / nylon manometer artificial bone, including hydroxyapatite which accounts for 50-66% of the total weight of the artificial bone; nylon which accounts for 34-50% of the total weight of the artificial bone; the hydroxyapatite disperses in the nylon under the dispersed phase with the average length between 60-80nm; the molecular weight of the nylon is between 9000-13000; in addition, the artificial bone is free of organic solvent. The invention can achieve high filling amount, no use of organic solvent, high product purity and can reach the standard set for the medical material.

Description

Technical field [0001] The invention relates to a polymer composite material and a preparation method thereof, in particular to a hydroxyapatite / nylon artificial bone and a preparation method thereof. Background technique [0002] The main inorganic component of natural bone is nano-hydroxyapatite, which is about 60-67% of bone tissue, and the organic component is mainly collagen, which accounts for about 33-40%. Using synthetic nano-acicular hydroxyapatite and polymer composite to prepare nano-artificial bone composite material, not only has the good biocompatibility and bone guiding characteristics of hydroxyapatite, but also combines the good mechanical properties of polymer materials and Biodegradable, it is a promising artificial bone composite material. [0003] Nylon (nylon 66) is a kind of polyamide, which is an engineering plastic with good comprehensive properties. It not only has good mechanical properties, but also has good biocompatibility and a certain degree of bio...

Claims

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Application Information

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IPC IPC(8): A61L27/46
Inventor 李兰杰杨桂生
Owner SHANGHAI GENIUS ADVANCED MATERIAL (GRP) CO LTD
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