Preparation of deinsectization carbamide controllable sustained-release nano grain and uses thereof

A technology of nanoparticles and diflubenzuron, which is applied to the preparation and application of diflubenzuron controlled-release nanoparticles, can solve the problems of reduced contact area, poor efficacy, hidden dangers to farmers and environmental health and safety, etc. The effect of low surface tension, improved drug efficacy, and alleviation of soil ecological environment problems

Inactive Publication Date: 2008-08-27
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of organic solvents in emulsifiable concentrates poses health and safety hazards to farmers and the environment
Due to the larger particles dispersed in the medium in the suspension, the contact area between diflubenzuron and the acting object is reduced, resulting in poor efficacy of this dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. The preparation method of diflubenzuron sustained-release nano-microsphere preparation

[0032] Components:

[0033] Diflubenzuron (a.i 100%) 10%

[0034] DMSO-solvent 15%

[0035] TSP-54 (Alkylphenol Polyoxyethylene Ether)-Emulsifier 13%

[0036] Witconol (Ethylene Oxide Propylene Oxide Block Copolymer) - Dispersant 6.5%

[0037] Polyethylene Glycol 200 - Crystallization Inhibitor 7.5%

[0038] Polyethylene Glycol 1000 - Crystallization Inhibitor 7.5%

[0039] Xanthan gum (polysaccharide) - stabilizer 0.4%

[0040] Soft water 40.1%

[0041] Process steps:

[0042] 1. At room temperature, mix polyethylene glycol 200, polyethylene glycol 1000 with water;

[0043] 2. Add TSP-54 and Witconol to DMSO, heat to 40°C until TSP-54 and Witconol are dissolved, add diflubenzuron, mix and stir until diflubenzuron is dissolved;

[0044] 3. Slowly add the solution prepared in step 2 to the solution in step 1.

[0045] 4. After 1 hour, add xanthan gum and polymeri...

Embodiment 2

[0046] Example 2. The preparation method of diflubenzuron sustained-release nano-microsphere preparation

[0047] Components:

[0048] Diflubenzuron (a.i 100%) 25%

[0049] DMSO-solvent 18%

[0050] TSP-54 (Alkylphenol Polyoxyethylene Ether)-Emulsifier 10%

[0051] Witconol (Ethylene Oxide Propylene Oxide Block Copolymer) - Dispersant 4.5%

[0052] Polyethylene Glycol 200 - Crystallization Inhibitor 3%

[0053] Polyethylene Glycol 1000 - Crystallization Inhibitor 3%

[0054] Xanthan Gum (Polysaccharide) - Stabilizer 1.5%

[0055] Soft water 35%

[0056] Process steps:

[0057] 1. At room temperature, mix polyethylene glycol 200, polyethylene glycol 1000 with water;

[0058] 2. Add TSP-54 and Witconol to DMSO, heat to 40°C until TSP-54 and Witconol are dissolved, add diflubenzuron, mix and stir until diflubenzuron is dissolved;

[0059] 3. Slowly add the solution prepared in step 2 to the solution in step 1. After 1 hour, add xanthan gum and polymerize for 1 hour to o...

Embodiment 3

[0060] Example 3. The effect of diflubenzuron controlled slow-release nanoparticles at a concentration of 1000 mg / L on third instar larvae of beet armyworm.

[0061] After corn leaves were treated with 1000 mg / L of diflubenzuron controlled slow-release nanoparticles, the third instar larvae (11±1 mg) of beet armyworm were fed for 4 days; the mortality rate was 100%.

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PUM

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Abstract

A method for preparing diflubenzuron controlled-releasing nanoparticles is provided, which comprises the following processing steps: step 1, a crystallization inhibitor and water are mixed at room temperature; step 2, a surface active agent is added into a water soluble solvent and is heated to 40 DEG until the surface active agent is dissolved, and then the technical grade diflubenzuron is added, mixed and stirred till the diflubenzuron is dissolved; step 3, the solution prepared in step 2 is slowly added into the solution in step 1; step 4, after an hour, a stabilizer is added, then the diflubenzuron controlled-releasing nanoparticles are prepared after the polymerization for an hour, and the particle diameters are below 1000 nm, most of which are between 100 to 300 nm. The diflubenzuron can be controlled to release, with reduced toxicity and side effects, increased bioavailability, reduced cost, and environment-friendliness.

Description

technical field [0001] The invention relates to a preparation method and application of diflubenzuron controllable slow-release nanoparticles. Background technique [0002] Diflubenzuron is currently a highly effective insecticide against Lepidoptera, and its main method of use is to formulate an aqueous solution and apply it to the target. Because diflubenzuron has poor water solubility, it is often dissolved in an organic solvent to make an emulsifiable concentrate, or it is dispersed in a liquid medium with a dispersant to make a suspension. Organic solvents are required in emulsifiable concentrates, and these organic solvents pose health and safety hazards to farmers and the environment. Due to the larger particles dispersed in the medium in the suspension, the contact area between diflubenzuron and the acting object is reduced, resulting in poor drug efficacy of this dosage form. One way to overcome these deficiencies is to reduce the particle size of diflubenzuron pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N47/34A01P7/00
Inventor 梅向东宋倩袁会珠宁君赵前飞马洪菊杨国权张涛李永红
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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