Double cladding water-based magnetofluid and method for producing the same

A double-coating and magnetic fluid technology, which is applied in the field of nanotechnology and biomedicine, can solve the problems of poor coating effect and weak magnetism, and achieve good magnetic response, small particle size and good monodispersity. Effect

Inactive Publication Date: 2008-09-03
JIAYING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are some deficiencies in the prior art. One, in the synthesis technology of magnetic nanoparticles, most of them are difficult to synthesize magnetic nanoparticles that fully meet the size requirements. For example, CN1702782A uses centrifugation to remove unstable particles. From the patent application According to the transmission electron microscope photo, the bonding phenomenon of the particles is obvious, indicating that the control conditions of the synthesis reaction and the effect of coating with polymer materials are not good; the second is that the magnetism is weak, for example, the saturation magnetization of the water-based magnetic fluid provided by CN1702782A is only 1.6 ~2.5emu / g, the saturation magnetization of water-based magnetic fluid prepared in all examples is less than 1.0emu / g

Method used

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  • Double cladding water-based magnetofluid and method for producing the same
  • Double cladding water-based magnetofluid and method for producing the same

Examples

Experimental program
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Effect test

Embodiment 1

[0018] (1) Weigh 27.029g FeCl 3 ·6H 2 Add O into the boiling double-distilled water, stir to dissolve, after cooling to room temperature, drop 3~5mL dilute hydrochloric acid, and then add 11.361g FeCl 2 ·4H 2 O, stir to dissolve, the total volume of the mixed solution is 1000mL, Fe in the mixed solution 3+ And Fe 2+ The ratio according to the amount of the substance is 1.75;

[0019] (2) Put the mixed solution in the reactor to preheat and stir to make it fully mixed, measure 85.0mL of 25% NH 3 ·H 2 O is poured into the reactor, NH 3 ·H 2 O can also be added dropwise or poured in several times, the stirring speed is gradually increased from 1000r / min to 2500r / min, the temperature is controlled at 35℃, the pH value of the solution is 10, and the constant temperature reaction is 60min to obtain nano-Fe 3 O 4 Particles

[0020] (3) Weigh 0.06g of medicinal agar into 6mL of distilled water, heat it at 90℃ to dissolve it, pour it into step (2), gradually increase the stirring speed fro...

Embodiment 2

[0025] (1) Weigh 108.116g FeCl 3·6H 2 Add O to the boiling double-distilled water, stir to dissolve, after cooling to room temperature, drop in 3~5mL HCl, and then add 45.444g FeCl 2 ·4H 2 O, stir to dissolve, the total volume of the mixed solution is 1000mL, Fe in the mixed solution 3+ And Fe 2+ The ratio according to the amount of the substance is 1.75;

[0026] (2) Put the mixed solution in the reactor to preheat and stir to make it fully mixed, and take 325mL of 25% NH 3 ·H 2 O was poured into the reactor, the stirring speed was gradually increased from 1000r / min to 3000r / min, the temperature was 35°C, the pH value of the solution was 10, and the constant temperature reaction was 60min. Get nano Fe 3 O 4 Particles

[0027] (3) Weigh 0.24g of medicinal agar into 24mL of distilled water, heat it at 90℃ to dissolve it, pour it into step (2), gradually increase the stirring speed from 1000r / min to 2500r / min, temperature 55℃, pH Value 7~8, react for 60min, get agar-coated nano Fe 3...

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Abstract

The present invention relates to a double covered water-based magnetic fluid and manufacture method thereof, the magnetic fluid includes water, nano Fe3O4 granule and dispersing agent, which is characterized in that grain diameter of nano Fe3O4 granule is 1-16 nm, dispersing agent is medicinal agaragar and polyethylene glycol at the covered surface of nano Fe3O4 granule, compound granule particle diameter obtained by medicinal agaragar and polyethylene glycol at the covered surface of nano Fe3O4 granule is smaller than 45nm; medicinal agaragar and polyethylene glycol is taken as dispersing agent, a double covered water-based magnetic fluid is produced by synthesizing of nano Fe3O4 granule and modus of surface step-by-step modification, which surface has function group; activity group of carboxy group and hydroxyl group, etc make the double covered water-based magnetic fluid with good magnetic responsiveness, biological affinity, biodegradability and suspension stability, saturation magnetization of magnetic fluid is 1.0-10.0emu/g used in biomedicine field for special therapy and diagnose of medicine carrier etc.

Description

Technical field [0001] The invention belongs to the fields of nanometer science and technology and biomedicine, and relates to a double-coated water-based magnetic fluid and a preparation method thereof. technical background [0002] The so-called magnetic fluid, also known as magnetic liquid, is a colloidal system formed by highly dispersing magnetic nanoparticles with surfactants in a carrier liquid. It combines the superparamagnetism of nano-solid materials and the fluidity of liquids. It is a new type of The liquid functional nanomaterials have been widely used in the fields of sealing, lubrication, damping, grinding, separation, printing, dyeing, and environmental protection. In recent years, magnetic fluid has expanded to cell separation in the field of biomedicine, tumor hyperthermia, MRI imaging, and targeted preparations. [0003] Due to the non-biocompatibility of non-water-based magnetic fluids, the field of biomedicine is mainly water-based magnetic fluids. However, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/44H01F1/10C04B35/26C04B35/622
Inventor 苑星海
Owner JIAYING UNIV
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