Weight bearing tissue engineering bone porous pure magnesium bracket and bracket imitation human bone material surface coatings

A tissue engineering bone and surface coating technology, applied in the field of biomedical engineering materials, can solve the problems of bone defects that cannot be applied to the weight-bearing parts of the limbs, lack of mechanical strength, etc., and achieve strong designability, good adhesion or affinity Effect

Inactive Publication Date: 2008-09-10
李秉哲 +2
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems that pDBM/hBMSC and other complexes lack certain mechanical strength in the early stage of clinical trials, and cannot be applied to bone defects in weight-bearing parts of limbs, etc., the present invention designs a porous pure magnesium scaffold for weight-bearing tissue eng

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Weight bearing tissue engineering bone porous pure magnesium bracket and bracket imitation human bone material surface coatings
  • Weight bearing tissue engineering bone porous pure magnesium bracket and bracket imitation human bone material surface coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] like figure 1 , 2 Shown: the porous pure magnesium scaffold for load-bearing tissue engineering bone of the present invention, the porous pure magnesium scaffold is composed of magnesium powder with a particle size of ≤150 μm and a purity of ≥99.9% and a granular organic powder with a particle size of 100-500 μm and a purity of ≥99.0%. Pore ​​agent, processed by powder metallurgy to make cylinders or discs with different diameters (D) and heights (H), and randomly distribute main holes (1), connected holes (2) and Blind holes (3), the main holes are connected with each other to form connected holes, and the blind holes are closed and not connected. The porous pure magnesium support is powder metallurgy, which is to mix the magnesium powder and the granular organic pore-forming agent evenly, pour it into the metal mold, and compress the prefabricated body under the pressure of 100MPa along the axial direction of the porous pure magnesium support; In an argon atmosphere...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Graininessaaaaaaaaaa
Graininessaaaaaaaaaa
Diameteraaaaaaaaaa
Login to view more

Abstract

A weight bearing tissue engineering bone porous pure magnesium stent and a surface coating of human bone simulating material of the stent are provided. The stent is made from high pure magnesium powder and pore former into cylinders or round plates with certain diameter (D) and height (H) through powder metallurgy and main holes (1), interlocking pores (2) and blind holes (3) are randomly distributed. The main holes are mutually communicated. The blind holes are enclosed. The total volume of all holes and pores occupies 35-55 percent of the outer contour volume of the stent. The volume of the blind holes occupies 2-5 percent in all holes and pores. The diameter of the main holes and the blind holes is 200-500Mum, and the diameter of communicating holes is 50-100Mum. The formation of the surface coating of the human bone simulating material of the stent (4) is that the stent is immersed in the coating solution with a constant temperature of 37 DEG C, and the coating solution contains Na<+>, K<+>, Ca<2+>, Mg<2+>, HCO3-, Cl<->, HPO4<2->, SO4<2-> and Type I collagen. Finally, the coating of the stent is formed into hydroxyapatite containing magnesium ions and the Type I collagen, and the thickness is 1-3Mum.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering materials, in particular to a porous pure magnesium bracket for load-bearing tissue engineering bone and a surface coating of the bracket imitating human bone material. Background technique [0002] In the bone tissue engineering of modern medicine, seed cells, biomaterials and tissue construction are the three most basic elements, and biomaterials or scaffold materials are one of the most critical factors affecting bone tissue construction, which must have good biocompatibility , degradability, low immunogenicity and certain spatial structure, porosity, degradation rate and other characteristics. [0003] According to different bone defect sites, different material scaffolds made of natural coral, tricalcium phosphate β-TCP and partially decalcified bone pDBM were selected, and the skull defects of sheep and dogs, the alveolar ridge bone defects of dogs and the mandible were succes...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/56A61L27/32A61L27/42
Inventor 李秉哲雷万军曹谊林卡尔・乌利希・凯纳崔磊周宁生彭淑鸽冯坤赵琳
Owner 李秉哲
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap