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Method for preparing composite artificial blood vessel stent by combined electro-spinning with knitting technique

A technology of artificial blood vessels and electrospinning, which is applied in the direction of textiles, stents, braids, etc., to achieve the effect of good growth activity and not easy to embolize

Inactive Publication Date: 2008-09-17
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the method of combining electrospinning technology and braiding technology to prepare vascular stents has not been reported.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 0.6g of poly-L-lactic acid / polyε-caprolactone copolymer P(LLA-CL) [50:50] (molar ratio) with an electronic balance, dissolve it in 10ml of trifluoroethanol, stir and oscillate until completely dissolved , to obtain a solution with a concentration of 6% (g / ml); for the solution prepared by electrospinning, the voltage is 16kv, the advancing speed of the syringe pump is 1ml / h, and the receiving distance is 10cm. The No. 7 needle is selected, the aluminum foil is grounded, and the roller is used. The receiving device is connected to a 3mm steel pipe for collection, and the electrospun P(LLA-CL) nanofibers with an average diameter of about 100nm are obtained as the inner layer of the tubular stent; a 16-spindle braiding machine is selected, and a braiding process angle of 70° is used to weave the inner diameter The optimal parameter of the 4mm regular structure is to use weaving equipment to weave the filamentary PLLA finished fiber material into a tubular shape, which...

Embodiment 2

[0028] Weigh 0.7g P(LLA-CL)[75:25] (molar ratio) with an electronic balance, dissolve it in 10ml of trifluoroethanol, stir and oscillate until it dissolves completely, and obtain a solution with a concentration of 7% (g / ml) The solution prepared by electrospinning, the voltage is 18kv, the injection pump advance speed is 1ml / h, the receiving distance is 12cm, the No. 7 needle is selected, the aluminum foil is grounded, and the steel pipe of 3mm is connected by the roller receiving device to collect, and the average diameter is obtained. Electrospun P(LLA-CL) nanofibers of about 100nm are used as the inner layer of the tubular stent; a 32-spindle braiding machine is selected, an 80° braiding process angle is used, and the braiding parameters of the regular structure with an inner diameter of 4mm are used. The finished PLGA (polylactic acid-polyglycolic acid) fiber material is braided into a tubular shape as the outer layer of the tubular stent; the inner layer formed by electros...

Embodiment 3

[0030] Weigh 0.8g PCL (polyε-caprolactone) with an electronic balance, dissolve it in 10ml of trifluoroethanol, stir and oscillate until it dissolves completely, and obtain a solution with a concentration of 8% (g / mL); prepared by electrospinning solution, the voltage is 20kv, the advancing speed of the syringe pump is 1ml / h, the receiving distance is 15cm, the No. 7 needle is selected, the aluminum foil is grounded, and the roller receiving device is connected to a 3mm steel pipe for collection, and the electrospun PCL with an average diameter of about 100nm is obtained. Nanofibers are used as the inner layer of the tubular stent; a 16-spindle braiding machine is selected, a braiding process angle of 60° is adopted, and the inner diameter of the braid is 4mm with regular structure braiding parameters, and the filamentary PLLA finished fiber material is braided into a tubular shape by braiding equipment, as The outer layer of the tubular scaffold; the electrospun inner layer an...

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Abstract

The invention relates to a preparation method of compound artificial blood vessel support by electrostatic textile and weave technology, which can be described as follows: 6% to 10% (g / ml) polymer spinning solution is prepared; under the control of electrostatic spinning parameter, the prepared solution is used to make nano fiber with electrostatic textile technology; the nano fiber is collected by a roller collecting device to be the inner layer of a tubular support; the fiber materials are woven into tubular form by making use of the textile equipment to be the outer layer of the tubular support; the electrostatically textile inner layer and the woven outer layer are compounded together with the method of hot shaping or coating; with the adoption of biocompatible implant technology, human endothelial cells are implanted on the inner layer of the support and human smooth muscle cells are implanted on the outer layer of the support; after cell culture, the blood support is completed. The preparation method of compound artificial blood vessel support through electrostatic textile and weave technology has the advantages of simplification and time-saving effect, fine growth activity of the prepared artificial blood vessel after being implanted into human body; besides, the smooth muscle can grow along and into the fiber, and adaptability adjustment can be made to the blood vessel according to the condition of the host, leaving less liability for embolization.

Description

technical field [0001] The invention belongs to the field of preparation of artificial vascular stents, in particular to a method for preparing composite artificial vascular stents by combining electrospinning and braiding techniques. Background technique [0002] In recent years, the incidence of vascular diseases such as coronary heart disease and arterial occlusive disease has been increasing day by day, and artificial vascular grafting has attracted much attention as the main means of treating vascular diseases. However, artificial blood vessels, especially small-caliber artificial blood vessels with a diameter of less than 6mm, lack growth activity after transplantation in the human body, cannot be adaptively adjusted according to the host condition, and are prone to embolism. [0003] Therefore, it is one of the effective methods to obtain satisfactory compatibility and long-term patency rate by using tissue engineering technology to produce small-caliber blood vessels...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61F2/82D01D5/00D03D1/00D03D3/02D04C1/06
Inventor 莫秀梅张建松钱永芳
Owner DONGHUA UNIV
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