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Oral preparation containing ampicillin, preparation method and application thereof

An ampicillin and preparation technology, applied in the field of therapeutic drugs and preparation thereof, can solve the problems of long time to reach effective blood drug concentration, easy to cause local pain reaction, inconvenient use of injections, etc., to avoid pain and inconvenience, and to take effect Fast, easy-to-administer results

Inactive Publication Date: 2008-09-24
北京亿利高科生物工程技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the inconvenient use of injections and the tendency to cause local pain reactions when administered
Oral absorption of tablets, etc. is slow, and the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is lower, and the time to reach the effective blood drug concentration in the lesion is also longer, affecting Its effective antibacterial potency

Method used

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  • Oral preparation containing ampicillin, preparation method and application thereof
  • Oral preparation containing ampicillin, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 - Ampicillin Candy

[0043] Prescription: 62.5g of ampicillin, 881g of sucrose, 10g of citric acid, 400.1g of food coloring, 10g of mannitol, 36.5g of hypromellose, and the dosage is 1000 tablets.

[0044] Method: Prepare a mixture of 62.5g of ampicillin, 10g of citric acid, 400.1g of food coloring, 10g of mannitol, and 36.5g of hypromellose, grind it, and pass it through a 20-mesh sieve. Take 881 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 2 grams. Then measure the disintegration time limit of ampicillin candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0045] Results: The disintegration time limit is 20-28 minutes, and the dissolution rate when completely disintegrated is 92%-95%.

Embodiment 2

[0046] Example 2-low sugar ampicillin candy

[0047] Prescription: Ampicillin 62.5g, sucrose 231g, fructooligosaccharide 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose 36.5g, dosage 1000 tablets .

[0048] Method: Prepare a mixture of citric acid 10g, food coloring-400.1g, mannitol 10g, and hypromellose 36.5g, grind it, and pass it through a 20-mesh sieve. Take 231g of sucrose, 300g of fructooligosaccharides, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, add the sieved mixture, stir rapidly for 10 minutes, cool to 85°C, add 62.5g of ampicillin, and quickly Stir for 10 minutes, place on a product forming machine and extrude, each lozenge weighs 2 grams. Then measure the disintegration time limit of ampicillin candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0049] Results: The disintegration time limit was 21-27 minutes, and the dissolution rate was 91%-96% when comp...

Embodiment 3

[0050] Embodiment 3-ampicillin buccal tablet

[0051] Prescription: 250 grams of ampicillin, 128 grams of hypromellose, polyethylene glycol 6000 621 grams, 1 gram of aspartame.

[0052] Method: Prepare 128 grams of hypromellose, polyethylene glycol 6000 621 grams, 1 gram of aspartame mixed matrix, heated and melted, cooled to 80 ° C, added 250 grams of ampicillin, stirred and mixed, cooled at room temperature until solidified, granulated, placed on a tablet machine and extruded, each tablet contains Tablets weigh 1 gram. Then measure the disintegration time limit of ampicillin buccal tablet in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0053] Results: The disintegration time limit was 28-32 minutes, and the dissolution rate was 93%-96% when completely disintegrated.

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Abstract

The invention relates to a buccal preparation containing ampicillin as well as a preparation method and usage thereof. The invention aims at providing a buccal preparation taking ampicillin as ingredient, which is dissolved in saliva of oral cavity by sucking to enter the periphery of the oral cavity, the pharyngeal portion and the pharyngeal tonsils part, so as to play the role of antibacterium. The buccal preparation takes the ampicillin and salt ramification thereof as the raw material, and can be made into preparations such as buccal tablet, candy and pill, etc. The buccal preparation has the characteristics of rapid effect, good healing efficacy and convenient administration, etc., and can directly increase the concentration of bacteriophage drug at the parts of pathological changes, enhances the antibacterial capacity and is more suitable for the patients.

Description

technical field [0001] The invention relates to a therapeutic drug and its preparation method and application, in particular to a buccal preparation containing ampicillin and its preparation method and application. Background technique [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/43A61P31/04A61P1/02A61P11/04
Inventor 刘凤鸣
Owner 北京亿利高科生物工程技术研究所有限公司