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Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

A transdermal and compound technology, applied in the field of traditional Chinese medicine for treating dysmenorrhea, to achieve the effects of high content of active ingredients, improved bioavailability and improved compliance

Inactive Publication Date: 2010-06-23
TIANJIN ZHONGBAO PHARMACY
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  • Abstract
  • Description
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Problems solved by technology

It has no direct inhibitory effect on the cerebral cortex, but it can block the ascending activation system and descending inhibitory function of the brainstem reticular structure

Method used

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  • Chinese medicine compound percutaneous absorption patch for treating menorrhalgia and preparation method thereof

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preparation example Construction

[0038] The preparation method of the traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea of ​​the present invention comprises the following steps:

[0039] (1) CO2 was used for the powder or coarse powder of Chinese herbal medicines Angelica and Turmeric respectively. 2 Supercritical extraction device, under the conditions of pressure 30MPa and temperature 50-55°C, extract for 3-4 hours to obtain angelica extract and turmeric extract respectively;

[0040] (2) The traditional ethanol extraction method is used for the material powder or coarse powder of the Chinese medicinal material Corydalis Corydalis to obtain Corydalis Corydalis extractum extract;

[0041] (3) Take angelica extract, turmeric extract, and β-cyclodextrin inclusion compound in proportion, and disperse them strongly through a nano-microemulsion disperser to control the microemulsion particles at the nanoscale to prepare a microemulsion dispersion;

[0042] (4) Add trans...

Embodiment 1

[0049] formula:

[0050] Angelica CO 2 Supercritical Extraction Oil 6g

[0051] Turmeric CO 2 Supercritical Extraction Oil 3g

[0052] Corydalis extract 16.5g

[0053] Transdermal absorption enhancer laurocapram Azone 3g

[0054] β-cyclodextrin inclusion complex 10g

[0055] Medical pressure sensitive adhesive 300g

[0056] Makes 350 stickers

Embodiment 2

[0058] formula:

[0059] Angelica CO 2 Supercritical Extraction Oil 1.5g

[0060] Turmeric CO 2 Supercritical Extraction Oil 3g

[0061] Corydalis extract 12g

[0062] Transdermal absorption enhancer Laurazone Azone 1.5g

[0063] β-cyclodextrin inclusion complex 9g

[0064] Medical pressure sensitive adhesive 300g

[0065] Makes 350 stickers

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Abstract

The invention discloses a Chinese traditional medicine compound trans-dermal absorption plaster for treating dysmenorrhea and a preparation method thereof. The plaster is prepared with the following materials by weight ratios: 0.5-3 shares of angelica extract, which is extracted from angelica by carbon dioxide supercritical extraction; 4-6 shares of fumitory extract, which is extracted from fumitory by traditional extraction method; 1-3 shares of turmeric extract, which is extracted from Chinese traditional medicinal materials by carbon dioxide supercritical extraction; 0.5-2 shares of trans-dermal accelerant; and 100-150 shares of pressure-sensitive adhesive. The materials are dispersed by nano-microemulsion dispersing machine intensively, and the particle diameter of the microemulsion is limited in nano-grade. The trans-dermal absorption preparation of the invention enters into the Subcutaneous capillary through skin cell gaps, and gets to the focus along with the blood circulation;the biological availability is improved by more than 10 times higher than the equivalent products, the curative effect is improved notably, the usage is convenient, and the adaptability of the sufferer is improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating dysmenorrhea, in particular to a traditional Chinese medicine compound transdermal absorption patch for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Transdermal drug delivery system or percutaneous absorption patch refers to a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. The characteristic of the transdermal absorption patch is that the transdermal drug delivery system can avoid the first-pass effect of the liver and the inactivation of the drug in the gastrointestinal tract. Effective blood concentration or physiological effects, avoiding the peak and valley phenomenon of blood concentration caused by oral administration. Reduce toxic and side effects, reduce a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/66A61K36/232A61K9/70A61K47/40A61P15/00A61P29/02
Inventor 高惠明杨吉田
Owner TIANJIN ZHONGBAO PHARMACY
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