Self-emulsifying vitamin C preparation and method of preparing the same and application thereof

A vitamin and self-emulsifying technology, applied in cosmetic preparations, skin care preparations, cosmetics, etc., can solve problems such as difficult absorption and unstable vitamin C, and achieve the effect of stable product quality and good self-emulsifying performance

Inactive Publication Date: 2008-10-08
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the instability of vitamin C itself and the lack of easy absorption by the skin, the present invention provides a self-emulsifying vitamin C preparation, which can

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take by weight respectively the egg yolk lecithin of 10%, the isopropyl myristate of 27%, the polyethylene glycol caprylic acid / capric glyceride of 22%, the glycerol of 30%, the vitamin E of 1%, Dissolve the above mixture at 60°C to form mixed solution A; then add 10% vitamin C aqueous solution to solution A at 40°C and a stirring speed of 500min-1 to form a transparent self-emulsifying vitamin C preparation. The vitamin C aqueous solution adopts citric acid and sodium citrate buffer solution with pH 5.5, and the concentration of vitamin C in the buffer solution is 15%.

Embodiment 2

[0044] Take by weight respectively the soybean lecithin of 1%, the sorbitan monooleate of 15%, the sorbitan monooleate of 22%, the natural squalane of 25%, the ubiquinone of 2% and 25% butanediol, heated in a water bath at 45°C to form a mixed solution A; then add 10% vitamin C aqueous solution to solution A at 60°C and a stirring speed of 600min-1 to form a transparent self-emulsifying vitamin C preparation . The vitamin C aqueous solution adopts citric acid and sodium citrate buffer solution with a pH of 6.0, and the concentration of vitamin C in the buffer solution is 20%.

Embodiment 3

[0046] Weigh respectively 8% egg yolk lecithin, 4% caprylic acid / capric triglycerin, 6% dioctyl carbonate, 20% polyglycerol isostearate, 25% propylene glycol, 5% Polyvinyl alcohol, 2% vitamin E acetate, dissolve the above mixture in a 30°C water bath to form a mixed solution A; then add 30% vitamin C to solution A at 30°C and a stirring speed of 2000min-1 Aqueous solution, forming a transparent self-emulsifying vitamin C preparation. The vitamin C aqueous solution adopts sodium dihydrogen carbonate and disodium bicarbonate buffer solution with a pH of 6.0, and the concentration of vitamin C in the buffer solution is 25%.

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PUM

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Abstract

The invention relates to a self-emulsified vitamin C preparation, a preparation method and application thereof, which pertains to the technical field of the latex and the latex preparation. The preparation consists of a lecithin in the weight percentage of 1 to 10%, a surfactant in the weight percentage of 20 to 50%, a cosurfactant in the weight percentage of 10 to 30%, a lipid material in the weight percentage of 10 to 30%, an antioxidant in the weight percentage of 0.1 to 2% and the vitamin C aqueous solution in the weight percentage of 10 to 30%. The materials are mixed evenly by stirring, so as to obtain the self-emulsified vitamin C preparation with a transparent or semitransparent appearance. The preparation can be self-emulsified in the water and form the latex with the grain diameter less than 300nm; the quality of the preparation is steady, thereby being applied to a cosmetic comprising the vitamin C.

Description

technical field [0001] The invention relates to a self-emulsifying preparation, in particular to a self-emulsifying vitamin C preparation and its preparation method and application, belonging to the technical field of cosmetics. Background technique [0002] Vitamin C plays an important role in biological redox and cellular respiration. Vitamin C is involved in amino acid metabolism, synthesis of neurotransmission, synthesis of collagen and tissue cells. In dermatology, large-dose oral vitamin C is used to treat acquired pigmentation diseases such as liver spots (brown spots) and Lille melanosis, and it has obvious effects. Vitamin C can inhibit abnormal pigmentation on the skin, inhibit the reaction of tyrosine-tyrosinase and play an anti-sensitization effect, and vitamins also have the effect of reducing dopachrome, an intermediate of tyrosine, preventing The production of melanin, which plays a role in whitening the skin. [0003] Vitamin C is water-soluble, it is diffi...

Claims

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Application Information

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IPC IPC(8): A61K8/84A61K8/67A61Q19/00
Inventor 段明星谢静红周华锋郑昌学严泽民
Owner TSINGHUA UNIV
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