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Porous magnetic gelatine microsphere and preparation thereof

A technology of gelatin and microspheres, which is applied in the field of functional polymer materials and organic-inorganic composite materials, can solve problems such as toxicity, unfavorable applications, and restrictions, and achieve the effects of high mechanical stability, uniform size, and large selectivity

Inactive Publication Date: 2008-10-08
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cross-linking agent remaining in the microspheres and the product of gelatin and cross-linking agent have certain toxicity, which is not conducive to its application in the biological and medical fields, which limits the cross-linking method.

Method used

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  • Porous magnetic gelatine microsphere and preparation thereof
  • Porous magnetic gelatine microsphere and preparation thereof
  • Porous magnetic gelatine microsphere and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The proportioning by weight of its raw material components is as follows:

[0030] Ammonia 100 parts

[0031] Magnetic particles 12 parts

[0032] 20 parts gelatin

[0033] Liquid paraffin 1400 parts

[0034] 12 parts of water-soluble emulsifier

[0035] Oil-soluble emulsifier 64 parts

[0036] TEOS 100 copies

[0037] Mix the ammonia solution, nano-magnetic particles, water-soluble emulsifier, and gelatin evenly according to the proportions of the above components, seal and soak for 3 hours. Heat and stir in a water bath at 60°C to completely dissolve the gelatin to form liquid A as the water phase.

[0038] In another three-necked flask equipped with a stirrer, add liquid paraffin dissolved with an emulsifier according to the above ratio, and stir evenly in a water bath at 60°C to form liquid B as the oil phase.

[0039] Slowly add liquid A to liquid B dropwise under rapid mechanical stirring, and continue stirring after the dropwise addition is complete. Afte...

Embodiment 2

[0041] The proportioning by weight of its raw material components is as follows:

[0042] Ammonia 100 parts

[0043] Magnetic particles 15 parts

[0044] 15 parts gelatin

[0045] Liquid paraffin 1400 parts

[0046] Water-soluble emulsifier 0 parts

[0047] Oil-soluble emulsifier 64 parts

[0048] TEOS 100 copies

[0049] Mix the ammonia solution, nano-magnetic particles, and gelatin evenly according to the proportions of the above components, seal and soak for 4 hours. Heat and stir in a water bath at 65°C to completely dissolve the gelatin to form liquid A as the water phase.

[0050] In addition, add the liquid paraffin dissolved with the oil emulsifier in the above ratio into a three-necked flask equipped with a stirrer, and stir in a water bath at 65°C to form B liquid as the oil phase.

[0051]Slowly add liquid A into liquid B dropwise under fast mechanical stirring, and increase the stirring speed rapidly after the dropwise addition is completed. After emulsific...

Embodiment 3

[0053] The proportioning by weight of its raw material components is as follows:

[0054] Ammonia 100 parts

[0055] Magnetic particles 20 parts

[0056] 25 parts gelatin

[0057] Liquid paraffin 1600 parts

[0058] 10 parts of water-soluble emulsifier

[0059] Oil-soluble emulsifier 74 parts

[0060] 60 servings of TEOS

[0061] Mix the ammonia solution, nano-magnetic particles, water-soluble emulsifier, and gelatin evenly according to the proportions of the above components, seal and soak for 3 hours. Heat and stir in a water bath at 60°C to completely dissolve the gelatin to form liquid A as the water phase.

[0062] In addition, add the liquid paraffin dissolved with the oil emulsifier according to the above ratio into a three-neck flask equipped with a stirrer, and stir in a water bath at 60°C to form B liquid as the oil phase.

[0063] Slowly add liquid A into liquid B dropwise under fast mechanical stirring, and increase the stirring speed rapidly after the dropw...

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Abstract

The invention belongs to the technical field of functional macromolecular materials and organic and inorganic composite materials, particularly relating to porous magnetic gelatin microspheres and the preparation method. The porous magnetic gelatin microspheres are produced as follows: the gelatin-coated magnetic gelatin microspheres of magnetic nano-particles are obtained through emulsification; then in the catalysis of ammonia, tetraethyl orthosilicate is hydrolyzed and condensed to form loose porous silicon dioxide on the internal and external surfaces of the magnetic gelatin microspheres so as to obtain the porous magnetic gelatin microspheres. The size of the microspheres is of micron degree. The method of the invention is simple to operate and highly efficient; the prepared microspheres are of uniform size; besides, the size of the microspheres and the coating thickness of the silicon dioxide can be adjusted based on reaction conditions. The microspheres have high thermal stability and mechanical stability, as well as high kernel type selectivity of magnetic particles. The microspheres have unique loose porous structures and can be used as fine carriers of drugs and enzymes and can also be used as vascular embolization materials and sewage treatment agents, with a very good application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials and organic-inorganic composite materials, and in particular relates to a porous magnetic gelatin microsphere and a preparation method thereof. Background technique [0002] Gelatin has good biocompatibility and degradability, and is widely used in the fields of biology, medicine, and chemical industry (Bruschi M L, Cardoso M L C, Lucchesi M B, International Journal of Pharmaceutics, 2003, 264: 45-55.). Magnetic gelatin microspheres prepared by embedding magnetic particles in gelatin can be used in the fields of drug sustained release, enzyme immobilization, vascular embolism and targeted drug delivery (Hu SH, Liu T Y, Liu D M, Journal of Controlled Release, 2007, 121: 181-189. Hu S H, Liu T Y, Tsai C H, Journal of Magnetism and Magnetic Materials, 2007, 310: 2871-2873.). Due to poor thermal stability of gelatin and easy swelling in water, crosslinking agents such as formalde...

Claims

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Application Information

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IPC IPC(8): C08J3/00C08L89/00C08K3/36C08K3/00C08K5/56
Inventor 袁俊杰张雄浦鸿汀万德成杨正龙
Owner TONGJI UNIV
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