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Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof

A traditional Chinese medicine preparation, a technology for chronic hepatitis B, applied in antitumor drugs, pharmaceutical formulations, medical preparations with non-active ingredients, etc. Safe and convenient to take medicine, enhance the effect of curative effect

Active Publication Date: 2009-01-14
陕西东泰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fat-soluble components bufolides in dried toad skin have significant anti-tumor effects, but there are major defects in the extraction of these two components in the current prior art: Cinobufacin Tablets, Chinese Patent (Application No. 200510005277.4) "Hua Toad (toad skin) extract production process", all adopt water extraction and alcohol precipitation process 1. Make a large amount of fat-soluble component bufolide in dry toad skin not extracted
3. Cinobufacini Tablets are sugar-coated tablets, taking a large amount, which is not easy for patients to accept
Chinese patent (200610167378.6) "total bufolide extract with anti-tumor effect, its preparation method and use", although Chinese patent (200610096075.X) "toad skin extract, its pharmaceutical preparation and its preparation method" respectively improve The content of indole alkaloids and bufolides was lowered, but a large amount of highly toxic and carcinogenic reagents such as methanol, chloroform, and acetone were used in the preparation process, and the clinical adverse reactions were many and serious.

Method used

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  • Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof
  • Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof
  • Traditional Chinese medicine preparation for treating median or late-stage malignant tumors, chronic hepatitis B, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Take 3500g of dry toad skin, cut into pieces, wash, add 85% ethanol to reflux for extraction twice, add 6 times the amount of ethanol for the first time, first soak for 2 hours, then reflux for 1 hour, add 4 times the amount of ethanol for the second time, Reflux and extract for 30 minutes, combine the extracts, filter, and use the dregs for later use. The filtrate is centrifuged at 4000r / min for 30 minutes, and the supernatant is collected to recover ethanol until it has no alcohol smell, and a clear ointment is obtained for later use; For the second time, add 8 times the amount of water for the first time, decoct for 1 hour, add 6 times the amount of water for the second time, decoct for 45 minutes, combine the decoction, filter, and centrifuge the filtrate at 4000r / min for 30 minutes, and take the supernatant The liquid is concentrated to a clear paste with a relative density of 1.08-1.12, combined with the above-mentioned clear paste, spray-dried into a fine powder, ...

Embodiment 2

[0094] Take 2500g of dry toad skin, cut it into pieces, wash it, add 85% ethanol to reflux and extract twice, add 6 times the amount of ethanol for the first time, first soak for 2 hours, then reflux and extract for 1 hour, add 4 times the amount of ethanol for the second time, Reflux and extract for 30 minutes, combine the extracts, filter, and use the dregs for later use. The filtrate is centrifuged at 4000r / min for 30 minutes, and the supernatant is collected to recover ethanol until it has no alcohol smell, and a clear ointment is obtained for later use; For the second time, add 8 times the amount of water for the first time, decoct for 1 hour, add 6 times the amount of water for the second time, decoct for 45 minutes, combine the decoction, filter, and centrifuge the filtrate at 4000r / min for 30 minutes, and take the supernatant The liquid is concentrated to a clear paste with a relative density of 1.08-1.12, combined with the above-mentioned clear paste, spray-dried into ...

Embodiment 3

[0096] Take 3000g of dry toad skin, cut into pieces, wash, add 85% ethanol to reflux and extract twice, add 6 times the amount of ethanol for the first time, first soak for 2 hours, then reflux and extract for 1 hour, add 4 times the amount of ethanol for the second time, Reflux and extract for 30 minutes, combine the extracts, filter, and use the dregs for later use. The filtrate is centrifuged at 4000r / min for 30 minutes, and the supernatant is collected to recover ethanol until it has no alcohol smell, and a clear ointment is obtained for later use; For the second time, add 8 times the amount of water for the first time, decoct for 1 hour, add 6 times the amount of water for the second time, decoct for 45 minutes, combine the decoction, filter, and centrifuge the filtrate at 4000r / min for 30 minutes, and take the supernatant The liquid is concentrated to a clear paste with a relative density of 1.08-1.12, combined with the above-mentioned clear paste, spray-dried into a fine...

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Abstract

The present invention discloses a Chinese medicine for curing advanced cancers and chronic hbv hepatitis and a preparation method. The present invention is proportionally manufactured by a medicinal active component made of dry toad skin and a medicine-acceptable carrier; the medicine carrier contains sodium carboxymethylcellulose and starch. Compared with the prior dosage, the present invention with advanced process and high medicine content strengthens the curing effect, reduces the toxic side effect of the medicine and ensures safer and more convenient medicine taking for patients.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating advanced tumors and chronic hepatitis B and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. technical background [0002] According to the World Health Organization (WHO) report, in the past ten years, the global tumor incidence has increased by 22%. No matter from the perspective of incidence (1.2 million) or death (1.1 million), tumor is the most important disease in the world. According to the prediction of World Health Organization experts, tumor will become the first killer of human beings in the new century. [0003] Hepatitis B is a serious infectious disease caused by hepatitis B virus (HBV). As many as 700 million people in my country have been infected with hepatitis B virus, of which more than 100 million people carry the virus for life, and more than 30 million people Become a chronic hepatitis B patient....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/48A61K47/38A61P35/00A61P1/16A61P31/20A61K35/65
Inventor 罗川
Owner 陕西东泰制药有限公司
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