Amoxicillin granule and production method thereof

A technology for amoxicillin and granules, which is applied in the field of preparing amoxicillin granules by micronization technology, can solve problems such as the application of micronization technology, and achieve the effects of reducing the amount of excipients, good dissolution rate, and simple preparation process

Inactive Publication Date: 2009-03-25
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Airflow ultrafine pulverization technology is a kind of ultrafine pulverization technology. It uses the material to obtain huge energy under the action of high-speed airflow, causing high-speed collision and severe friction between material particles in the pulverization chamber. Shearing effect, so as to achieve the purpose of crushing materials, it can process raw materials into very fine powder, at present, this technology is mainly used in traditional Chinese medicine, almost no micronization technology is applied to chemical drugs or western medicine, used to improve medicine Application of formulation defects

Method used

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  • Amoxicillin granule and production method thereof
  • Amoxicillin granule and production method thereof
  • Amoxicillin granule and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Amoxicillin Granules

[0036] Weigh 1250g of amoxicillin and 1000g of lactose and mix evenly, inject the mixture and dry nitrogen into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.2MP, the internal working temperature is 50°C, the pulverization time is 40min, and then take out Fine powder, passed through a 500-mesh sieve, all passed, the fine powder and 100g sodium carboxymethyl cellulose, 2500g sucrose, 200g aspartame, 150g orange essence, 80g citric acid were mixed evenly, and the syrup solution was added to prepare the soft material , pass through a 20-mesh sieve to make wet granules, dry at 50°C, granulate through a 20-mesh sieve, and pack into bags.

Embodiment 2

[0037] Example 2 Preparation of Amoxicillin Granules

[0038] Weigh 1000g of amoxicillin and 800g of mannitol and mix evenly, inject the mixture and dry air into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.0MP, the internal working temperature is 45°C, and the pulverization time is 30min, then Take out the fine powder, pass it through a 1000-mesh sieve, and pass it all, mix the fine powder with 150g hypromellose, 2300g sucrose, 500g sorbitol, 100g strawberry essence, 66g malic acid, add 5% povidone K30 ethanol solution and mix Prepare soft materials, pass through a 20-mesh sieve to make wet granules, dry at 50°C, granulate through a 20-mesh sieve, and pack into bags.

Embodiment 3

[0039] Example 3 Preparation of Amoxicillin Granules

[0040] Weigh 500g of amoxicillin and 800g of sucrose and mix evenly, inject the mixture and dry air into the ultrafine pulverizer, use high-speed airflow to pulverize, the working pressure is 1.1MP, the internal working temperature is 60°C, the pulverization time is 35min, and then take out Fine powder, passed through 800 mesh sieve, all passed, fine powder mixed with 200g mannitol, 35g sodium carboxymethyl cellulose, 18g orange essence, 46g tartaric acid, added 5% povidone K30 ethanol solution and mixed to prepare soft material, Pass through a 20-mesh sieve to make wet granules, dry at 50°C, sieve through a 20-mesh sieve, add 12.24 g of talcum powder, mix well, and pack into bags.

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Abstract

The invention provides amoxicillin granules and the production method thereof, in particular relates to a method of adopting the micropowder technology to prepare amoxicillin granules. The method is characterized in that the method includes the steps that a superfine pulverizer is used to pulverize amoxicillin to obtain fine powder with the particle size of 25um-50um. The amoxicillin granules prepared by the method have the advantages of good dissolution, good stability, greatly reducing the dosage of auxiliary material, reducing the toxic and side effects, simple preparation process and easy operation.

Description

technical field [0001] The invention relates to a method for producing amoxicillin granules, in particular to a method for preparing amoxicillin granules by micronization technology. It belongs to the field of medical technology. Background technique [0002] Amoxicillin is a penicillin antibiotic, which is effective against aerobic gram-positive cocci such as Streptococcus pneumoniae, hemolytic streptococcus, non-penicillinase-producing Staphylococcus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Non-lactam-producing mold strains of aerobic Gram-negative bacteria such as Salmonella, Haemophilus influenzae, and Neisseria gonorrhoeae and Helicobacter pylori have good antibacterial activity. Amoxicillin exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls, and can rapidly dissolve and rupture bacteria into spheroids. Clinically, it is mainly used for respiratory tract infection, typhoid fever and urinary tract infection caused by se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/43A61P31/04
Inventor 邱民
Owner HAINAN MEIDA PHARMA
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