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Method for preparing specificity function magneto fluid

A magnetic fluid and specific technology, applied in the field of nanotechnology and biomedicine, can solve the problems of wide particle size distribution, limited application, large particle size of magnetic starch composite particles, etc., so as to improve product performance, reduce production cost, good The effect of biocompatibility

Inactive Publication Date: 2009-04-15
徐州诺特化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large particle size and wide particle size distribution of magnetic starch composite particles, its application in the field of biomedicine is limited, especially in the application of magnetically targeted drug technology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A mixed solution of 0.6mol / L Fe2+ and 0.3mol / L Fe3+ and a 0.2mol / L NaOH solution were prepared respectively with double distilled water. Add 3 parts by weight of poly-5-hydroxymethylfurfural to 40 parts of double-distilled water, and heat to 60° C. to dissolve it.

[0027] Take 50ml of the iron salt mixed solution and add it to the poly-5-hydroxymethylfurfural solution, and at the same time add it to the rotating packed bed reactor, adjust the rotation speed, and control the supergravity that produces a centrifugal acceleration of 300-900g. Control the temperature at 70-80°C, add the measured NaOH aqueous solution dropwise within 1.5-2.5 hours, and continue to maintain the supergravity field for 1 hour. Stop the rotation, adjust the pH value of the suspension to 7 with dilute hydrochloric acid in the obtained black magnetic suspension, centrifuge to remove the precipitate in the solution, and then dialyze the sample through double distilled water for 2 to 3 days to remo...

Embodiment 2

[0032] A mixed solution of 0.8mol / L Fe2+ and 0.3mol / L Fe3+ and a 0.4mol / L NaOH solution were prepared respectively with double distilled water. Add 5 parts by weight of poly-5-hydroxymethylfurfural to 50 parts of twice-distilled water, and heat to 60° C. to dissolve it.

[0033]Take 80ml of the iron salt mixed solution and add it to the poly-5-hydroxymethylfurfural solution, and at the same time add it to the rotating packed bed reactor, adjust the rotation speed, and control the supergravity that produces a centrifugal acceleration of 500-800g. Control the temperature at 80-90°C, within 1.5-2.0 hours, add the measured NaOH aqueous solution dropwise, and continue to maintain the supergravity field for 1.5 hours. Stop the rotation, adjust the pH value of the suspension to 7 with dilute hydrochloric acid in the obtained black magnetic suspension, centrifuge to remove the precipitate in the solution, and then dialyze the sample through twice distilled water for 2 to 3 days to rem...

Embodiment 3

[0038] A mixed solution of 0.6mol / L Fe2+ and 0.3mol / L Fe3+ and a 0.5mol / L NaOH solution were prepared respectively with double distilled water. Add 8 parts by weight of poly-5-hydroxymethylfurfural to 60 parts of twice-distilled water, and heat to 60° C. to dissolve it.

[0039] Take 120ml of the iron salt mixed solution and add it to the poly-5-hydroxymethylfurfural solution, and at the same time add it to the rotating packed bed reactor, adjust the rotation speed, and control the supergravity that produces a centrifugal acceleration of 800-900g. Control the temperature at 80-95°C, within 1.5-2.0 hours, add the measured NaOH aqueous solution dropwise, and continue to maintain the supergravity field for 2.0 hours. Stop the rotation, adjust the pH value of the suspension to 7 with dilute hydrochloric acid in the obtained black magnetic suspension, centrifuge to remove the precipitate in the solution, and then dialyze the sample through twice distilled water for 2 to 3 days to r...

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Abstract

The invention relates to a preparation method of a specific functional magnetic fluid; the preparation method is characterized in that water solution containing Fe<+3> and Fe<+2> is taken as raw material, the hydrolysis and the surface modification with NaOH water solution and poly-5-hydroxymethyl-furfural water solution in a supergravity field are carried out to obtain the surface modified magnetic fluid, the surface modified magnetic fluid is further coupled and combined with a synthesis oriented peptide to obtain the specific functional magnetic fluid with biocompatibility, biodegradability, bio-penetrating, magnetic response, nanoparticle property and the like; poly-5-hydroxymethyl-furfural is a soluble polymer organic matter which is obtained by polymerization of a biobased material 5-hydroxymethyl-furfural, the synthesis oriented peptide is generated by peptide formation reaction of various amino acids in an organic solvent under the action of a catalyst and at a certain temperature, and the oriented peptides with the different specific functions and the different uses can be obtained by controlling the types of the amino acids, the mixture ratio, the synthesis process conditions, etc.

Description

technical field [0001] The invention relates to a preparation method of a specific functional magnetic fluid, which belongs to the field of nano science technology and biomedicine. Background technique [0002] Magnetic fluid, also known as magnetic liquid, is one of the important application fields of nanomaterials. It has both solid magnets and fluid materials, and is a new type of liquid functional material. Early ferrofluids were mainly used in sealing, lubrication, separation, printing and dyeing, and environmental protection, and achieved substantial success. In recent years, with the development of nanotechnology and the application of some new technologies, the surface of magnetic nanoparticles has been modified and modified, so that they not only have the usual properties of nanoparticles, but also have biocompatibility and biodegradability. And magnetic responsiveness and other specificities, so it has been widely used in the field of biomedicine, such as immobili...

Claims

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Application Information

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IPC IPC(8): H01F1/44H01F41/02C09C1/24C09C3/10C09C3/08
Inventor 王玉成高玉忠王理想王友志杨凯王圣良曹再林张春来张文娟靳长娟徐安民王乃剑
Owner 徐州诺特化工有限公司
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