Process for producing medical endotracheal tube with anti-bacterial adherence function and photoinduction disinfection function

An anti-bacterial adhesion, endotracheal catheter technology, applied in the direction of catheter, coating, etc., to achieve the effect of good performance stability

Active Publication Date: 2009-05-13
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been a lot of reports on the film formation of photocatalysts on the surface of materials that can withstand high temperature treatment, such as metals, ceramics, and glass. However, the film formation on the surface of polymer materials,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] 1. TiO 2 and the preparation of composite oxide coating solution

[0025] TiO 2 and the preparation of the composite oxide coating solution has two methods: one is to adopt the conventional method to prepare the TiO 2 and its composite oxide colloidal solution as the precursor, and the second is to use commercial TiO 2 The powder and its composite oxide are precursors.

[0026] (1) When the precursor is a sol, the TiO 2 And its composite oxide sol is subjected to airtight heat treatment at a certain temperature in a stainless steel high-pressure reactor with PTFE lining, so that the sol is transformed into anatase-containing TiO 2 crystalline sol. Here, TiO 2 Composite oxides made of TiO 2 With ZnO, SiO 2 one or both components. The semiconductor composite oxide can also be doped with transition metal ions, rare earth element ions or other N, S, P nonmetal ions. The heat treatment temperature of the reactor is 90-200°C, and the treatment time is 2-30 hours. T...

Embodiment 1

[0030] Embodiment 1 Preparation of organic polymer binder

[0031] 20 grams of PVC particles were weighed and dissolved in 1000 mL of tetrahydrofuran solvent, stirred and dissolved to obtain a PVC organic polymer binder using tetrahydrofuran as a solvent.

Embodiment 2

[0032] Example 2: TiO 2 Preparation of sol-type coating solution

[0033] First, the TiO prepared by conventional sol-gel method 2 Sol 200mL (TiO 2 The solid content is 3.0wt%) placed in a closed stainless steel autoclave with polytetrafluoroethylene lining for heat treatment at 150 ° C for 2 hours to obtain crystallized TiO 2 Sol. Then 80mL of this sol was mixed with 20mL of the organic polymer binder prepared in Example 1, and after vigorous stirring, it became suspended TiO 2 Sol type coating solution. In this coating solution, TiO 2 The solids content was 2.4 wt%.

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PUM

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Abstract

The invention provides a method for preparing a medical tracheal catheter capable of resisting bacterial adhesion and performing photo-induced sterilization. The method includes the preparation of TiO2 and a composite oxide coating liquid, and the film forming of a coating liquid on the inner surface of a PVC tracheal catheter. Specifically, the preparation method comprises the following steps: a suspension coating liquid is formed by mixing and dissolving an organic polymer binder in a crystalline state semiconductor oxide sol or a suspension characterized by photo-catalytic activity; and then a thin film with the advantages of high bonding strength, good anti-bacterial performance and excellent lighting sterilization performance is formed by plating the coating liquid uniformly on the surface of the inner wall of a tracheal catheter with a modified surface. The preparation technology can enable the medical PVC tracheal catheter to resist bacterial adhesion and to retain the effectiveness and stability of the photo-induced sterilization performance for a long period.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and more specifically relates to a technology for loading a photocatalytic film with anti-bacterial adhesion and light-induced bactericidal properties on the inner wall surface of a medical PVC tracheal catheter. Background technique [0002] With the continuous development of medicine, the application of biomaterials has become increasingly common, and the biomaterial-associated infection caused by bacteria adhering to the surface of biomaterials to form a biofilm has become an increasingly important problem. The wide application of artificial organs and components of polymer materials in medical treatment has increased the ways for bacteria to invade the human body. Among them, the respiratory infection caused by PVC endotracheal tube is a typical example. Long-term placement of polyvinyl chloride (PVC) tracheal tubes is an important cause of nosocomial respiratory infections, resulting in ...

Claims

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Application Information

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IPC IPC(8): A61L29/10A61L29/04
Inventor 付贤智王绪绪林华香林群戴文新许紫婷
Owner FUZHOU UNIVERSITY
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