Chinese medicine granule containing total phenolic acids in salvia root and preparation method thereof
A technology of total phenolic acids of salvia miltiorrhiza and traditional Chinese medicine granules is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients, etc. Unsightly and other problems, to achieve the effects of good physical properties, good particle fluidity, and short dissolution time
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Embodiment 1
[0046] Preparation of total phenolic acids of salvia miltiorrhiza: 5 kg of salvia miltiorrhiza was crushed into coarse powder, added with deionized water and heated at 90-100° C. for extraction three times. Add 30L water for the first time and heat for 1 hour; add 15L water for the second and third times and heat for 1 / 2 hour respectively. The extract was concentrated under reduced pressure at 40-45°C to 5L, after cooling, 14L of 95% ethanol was added, allowed to stand overnight, and filtered. The filtrate reclaims ethanol under reduced pressure at 40-45°C, and the resulting concentrated solution passes through RA type macroporous adsorption resin (produced by Beijing No. If there is no α-naphthol reaction in the solution, continue to elute with 50% ethanol until the eluent is added with ferric trichloride potassium ferricyanide reagent and there is no obvious phenolic hydroxyl reaction. The eluate was concentrated under reduced pressure at 40-45°C, then placed in the refrige...
Embodiment 2
[0058] Preparation of total phenolic acid of salvia miltiorrhiza: with the same method as in Example 1, the difference is that the extraction temperature of the coarse powder of salvia miltiorrhiza after adding deionized water is 70°C, and the extraction is performed 4 times, and the heating time is respectively: 1.2 for the first extraction. hour, 1 hour during the second extraction, and 0.8 hour for the third and fourth extractions; the preparation obtains the total phenolic acid of salvia miltiorrhiza;
[0059]Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as the base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, ...
Embodiment 3
[0062] Preparation of total salvianolic acid: take 200 g of total salvianolic acid obtained according to the method of Example 1.
[0063] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and screen out the master batch with a particle size of 300μ-400μ for future use.
[0064] Preparation of the product: Take 450g of masterbatch, 50g of microcrystalline cellulose...
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