Process for preparing strontium-doped calcium polyphosphate biological active bone cement

Abstract

The invention discloses a process for preparing fermorite-doped biological active bone cement. The cement solid phase adopted by the process is a mixture comprising tracalcium phosphate and Alpha-calcium phosphate which are distributed in a certain grain fineness and prepared according to a certain molar ratio, wherein, the Alpha-calcium phosphate strontium salt powder is a mixture comprises Alpha-SrxCa3-x(PO4)2 or Alpha-Sr3(PO4)2 and Alpha-Ca3(PO4)2 powder which are mixed by a certain molar ratio; the aqueous phase is a water deionized dilute phosphoric acid solution or a dilute phosphoric acid solution with the concentration being lower than 2 mol / l; the solid-to-liquid mass ratio is 1.0 to 4.0; and the final product under the physiological environment is strontium-doped hydroxylapatite. The cement has the advantages that the strontium doping content and the calcium strontium / phosphorus ratio are adjustable; the manufacturing technology is simpler; and the like. Compared with calcium phosphate bone cement of other types, the biological active bone cement has wider application prospect.

Description

technical field [0001] The invention relates to a preparation process of bioactive bone cement, in particular to a preparation process of strontium-doped apatite bioactive bone cement. Background technique [0002] Calcium Phosphate Cement (CPC) has a porous structure and the cured product is hydroxyapatite, which has good biocompatibility and osteoconductivity, and can be processed into a slurry form and directly injected into bone defects and In situ solidification, thus widely used in dental bone replacement, orthodontic and reconstructive surgery. Calcium phosphate bone cement is mainly composed of two parts: calcium phosphate powder and curing liquid. The solidification solution is generally water or dilute phosphoric acid aqueous solution, and the calcium phosphate powder mainly includes tetracalcium phosphate (Ca 4 (PO 4 ) 2 O), calcium hydrogen phosphate (CaHPO 4 2H 2 O or CaHPO 4 ), calcium dihydrogen phosphate (Ca(H 2 PO 4 ) 2 ·H 2 O or Ca(H 2 PO 4 ) ...

AI Technical Summary

Problems solved by technology

In 2001, French scholars (L.Lerous, J.L.Lacout.Preparation of calcium strontium hydroxyapatites by a new route involving calcium phosphate cements.J.Mater.Res.2001,16(1):171~178) first used calcium phosphate bone cement Strontium-containing hydroxyapatite was synthesized by the method, and the solid phase powder used was Ca 4 (PO 4 ) 2 O and α-Ca 3 (PO 4 ) 2 , the liquid phase is Sr(NO 3 ) 2 with H 3 PO 4 Aqueous solution, but the disadvantage is that the final cured product contains a large amount of NO which is harmful to human tissue 3 - ions, not suitable for clinical applications such as human bone repair, follow-up research on mechanical properties and similar content have not been reported

From the perspective of industrial production cost, it is generally believed that more complex technical links will often lead to an increase in mass production costs