Regenerative medical material and preparation method and application thereof

Abstract

The invention provides a regenerative medical material for promoting soft or hard tissue repair and a preparation method and application thereof. The regenerative medical material has a three-dimensional network structure and is a composite material prepared from inorganic matter and organic matter, wherein the mass ratio of the inorganic matter to the organic matter is 2:1 to 4:1. Based on the total mass of the inorganic matter, the inorganic matter contains 12-38% of SiO2, 3-5% of Na2O, 15-29% of CaO, 10-32.5% of P2O5, 1-5% of inositol hexaphosphate, 1-5% of inositol hexaphosphoric acidand the balance impurities, and the content of the impurities is 0.5% or below. Based on the total mass of the organic matter, the organic matter contains 30-60% of carboxymethyl chitosan and 30-60% of sodium hyaluronate. The regenerative medical material has the composition and the properties suitable a human body and has the key effect on the aspects of cell repair and bonding, cell proliferation and promotion of hair follicle growth.

Description

technical field [0001] The invention relates to the field of regenerative medicine, in particular to a regenerative medical material and its preparation method and application. Background technique [0002] The most notable feature of bioactive glass and glass ceramics is that after being implanted into the human body, the surface condition changes dynamically over time, and a bioactive hydroxycarbonate apatite (HCA) layer forms on the surface, providing a bonding interface for tissues. Most bioactive glasses are Class A bioactive materials, which have both osteoproductive and osteoconductive effects, and have good integration with bone and soft tissue. Bioactive glass (BAG) is considered to be a Good biomaterials for prosthetic applications. This restorative material is not only widely used, but also has irreplaceable magical effects in professional products in many fields, such as skin care, whitening and wrinkle removal, burns and scalds, oral ulcers, gastrointestinal ul...

AI Technical Summary

Problems solved by technology

[0003] But this kind of bioglass has some key problems: 1. The degradation rate is slow, and it usually takes 1-2 years to completely degrade; 2. The pH value is unstable, and its pH value can reach 11, forming a strong alkalinity and having certain cytotoxicity ; 3. This kind of biological glass adopts melting and quenching reaction temperature is very high, at 1700-1900 ℃, resulting in high energy consumption, and the construction of a standard production line needs to invest more than 1 billion yuan; 4. This kind of biological glass cannot form porous materials, which is difficult to realize Highly compatible with materials and extended functions

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