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Method for preparing PAMAM dendrimer-modified gold nanorod composite carrier

A technology of dendrimers and gold nanorods is applied in the field of preparation of gold nanorod composite carriers, which can solve the problems of high cost and limited connection of biomolecules, and achieve the effects of less equipment, easy promotion and low energy consumption.

Inactive Publication Date: 2009-06-03
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantages of these methods are: after modification, it is connected with biomolecules, and chemical synthesis is still required, the biomolecules to be connected are limited, and the cost is high

Method used

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  • Method for preparing PAMAM dendrimer-modified gold nanorod composite carrier
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  • Method for preparing PAMAM dendrimer-modified gold nanorod composite carrier

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Experimental program
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Embodiment 1

[0021] a) Weigh 0.103g chloroauric acid (HAuCl 4 ) and 0.065g (2.5×10 -4 mol / L) sodium citrate was dissolved in 10mL deionized water, and 0.6mL1.67×10 2 mol / L sodium borohydride (NaBH 4 ) to obtain a pink solution of gold nano-seeds, which are used 2-5 hours after preparation.

[0022] b) Weigh 0.103g (2.5×10 -4 mol) chloroauric acid (HAuCl 4 ) and 36.445 g (0.1 mol) of cetyl ammonium bromide (CTAB) were dissolved in 10 mL of deionized water, mixed with 0.05 mL of a freshly prepared aqueous solution of vitamin C containing 17.612 g (0.1 mol) of ascorbic acid, and then added to it The prepared 0.025mL gold nanometer seed solution was aged for 48h to obtain gold nanorods.

[0023] c) Add 5 ml of methyl thioglycolate to 20 mL of an aqueous solution containing 10 mg of freshly prepared G5.0 aminated PAMAM dendrimers, stir and react at 50° C. for 9 h, then vacuum-dry at 70° C. to obtain thiolated PAMAM dendrimers.

[0024] d) Take 10 mL of thiolated PAMAM dendrimer solution a...

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Abstract

The invention relates to a method for preparing a PAMAM dendrimer-modified gold nanorod composite carrier, belonging to the field of nanocomposite materials. In the method, gold ions are firstly reduced into gold nanoseeds through the chemical reduction method in the presence of a coating agent, and the seeds are added into the growth solution of the gold ions for preparing gold nanorods, wherein, the growth solution contains the gold ions, a weak reducing agent and a surfactant; amino-PAMAM dendrimers of any generation are reacted with methyl mercaptoacetate, and mercapto-PAMAM dendrimers are obtained; finally, a hybrid reaction is carried out on the gold nanorods and the mercapto-PAMAM dendrimers, and PAMAM dendrimer-modified gold nanorod composite carrier is obtained. In the composite carrier, the PAMAM dendrimers are evenly coated on the surface of each gold nanorod in the composite carrier, and the maximum absorption peak of the composite carrier is about 542nm and 871nm.

Description

technical field [0001] The invention relates to a preparation method in the technical field of nanocomposite materials, in particular to a preparation method of a gold nanorod composite carrier modified by PAMAM dendrimers. Background technique [0002] In recent years, as a new class of noble metal nanomaterials, gold nanorods have unique optical properties and have been widely used in the fields of electricity, optics, chemistry and biology. The huge potential in this area has attracted widespread attention. The special optical properties of gold nanorods depend on their own size and shape, which are completely different from gold nanoparticles. Gold nanorods have two surface plasmon absorption bands, one is the transverse plasmon absorption band, the absorption and scattering of light is along the short axis of the nanorod, and is located near 520nm of visible light; the other is the longitudinal plasmon absorption band, the absorption and scattering of light is along th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/02C30B29/02C30B29/62C30B33/00A61K47/00A61K49/00
Inventor 崔大祥黄鹏高峰贺蓉
Owner SHANGHAI JIAO TONG UNIV
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