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Lamivudine tablet and preparation method

A lamivudine tablet and lamivudine technology are applied in the directions of pill delivery, antiviral agents, pharmaceutical formulations, etc., to achieve the effects of simple and easy process, convenient operation and convenient source.

Active Publication Date: 2009-06-24
ANHUI BIOCHEM BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the problem of relying on foreign companies to provide expensive lamivudine at present, the present invention provides a lamivudine tablet with controllable quality and low price and its preparation method

Method used

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  • Lamivudine tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get the following raw materials: lamivudine 100g, microcrystalline cellulose 90g, sodium carboxymethyl starch 15g, hypromellose 1g, magnesium stearate 1g, 50% ethanol 90g.

[0026] The preparation method of lamivudine tablet comprises the following processing steps:

[0027] (1) take by weighing lamivudine, microcrystalline cellulose, sodium carboxymethyl starch of above-mentioned parts by weight and cross 100 mesh sieves respectively;

[0028] (2) uniformly mixing microcrystalline cellulose and lamivudine to obtain a mixture;

[0029] (3) take by weighing 50% ethanol, hypromellose of above-mentioned weight portion and stir, add in the mixture that step (2) makes as binder, make soft material, cross 20 mesh sieves and make granule, Dry in an oven below 65°C to obtain dry granules;

[0030] (4) carry out granulation by passing dry granule through 20 mesh sieves;

[0031] (5) adding magnesium stearate and sodium carboxymethyl starch in the above-mentioned parts by weig...

Embodiment 2

[0037] Get the following raw materials: lamivudine 100g, microcrystalline cellulose 100g, sodium starch glycolate 20g, hypromellose 3g, magnesium stearate 3g, 50% ethanol 100g. 1000 lamivudine tablets can be prepared, each containing 100 mg of active ingredient lamivudine. All the other are with embodiment 1.

Embodiment 3

[0039] Get the following raw materials: lamivudine 100g, microcrystalline cellulose 110g, sodium starch glycolate 25g, hypromellose 5g, magnesium stearate 5g, 50% ethanol 110g. 1000 lamivudine tablets can be prepared, each containing 100 mg of active ingredient lamivudine. All the other are with embodiment 1.

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Abstract

The invention relates to a lamivudine tablet and a preparation method thereof, which solve the problem of expensive cost due to the fact that lamivudine is provided by foreign companies at present. The lamivudine tablet consists of the following raw materials by weight portion: 100 portions of lamivudine, 90 to 110 portions of microcrystalline cellulose, 15 to 25 portions of carboxymethyl starch sodium, 1 to 5 portions of hydroxypropyl methyl cellulose, 1 to 5 portions of magnesium stearate, and 90 to 110 portions of 50 percent alcohol. The lamivudine tablet has convenient raw material sources, low cost, simple production process, and convenient and quick operation, and is easy to process a main medicine, namely the lamivudine with an active ingredient into a tablet which satisfies the drug standard; and the preparation method has a simple and easy process, and steady and controllable product quality.

Description

technical field [0001] The invention relates to a lamivudine tablet and a preparation method thereof. Background technique [0002] Lamivudine, whose chemical name is (2R-cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-1H-pyrimidine -2-one [0003] Its chemical structural formula is as follows: [0004] [0005] Molecular formula: C 8 h 11 N 3 o 3 S [0006] Molecular weight: 229.26 [0007] Lamivudine is a nucleoside antiviral drug. It has a strong inhibitory effect on hepatitis B virus (HBV) in vitro and in experimentally infected animals. Lamivudine can be metabolized in HBV-infected cells and normal cells to produce lamivudine triphosphate, which is the active form of lamivudine, which is both an inhibitor of HBV polymerase and a substrate of this polymerase. Lamivudine triphosphate penetrates into the viral DNA strand and blocks the synthesis of viral DNA. Lamivudine triphosphate does not interfere with the metabolism of deoxynucleosides in normal cel...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/513A61P31/12
Inventor 邢怀阳操铖金忠红刘斌郭翠平沈蔡月
Owner ANHUI BIOCHEM BIO PHARMA
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