Chinese medicine solid preparation for treating climacteric syndrome and preparation method thereof

A technology for solid preparations and syndromes, applied in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as hindering domestic and overseas expansion, low level of production automation, and difficult product quality control. The effect of modern production, good bioavailability and convenient storage

Active Publication Date: 2009-06-24
BEIJING TONGRENTANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This variety is still a traditional raw powder water honeyed pill formulation at present. The water honey pill has the characteristics of mild and long-lasting effect, can cover the bad smell of the medicine, and is convenient to take. However, the preparation method of the traditional Chinese medicine water honey pill is still relatively backward, and the production automation level is low. Large, inconvenient to take, and difficult to control product quality, thus hindering the domestic and overseas expansion of this variety. Therefore, it is urgent to transform the dosage form of this drug, and develop a drug that can not only maintain its original curative effect, but also facilitate modern production, dissolution rate and biological properties. The utilization is better than that of pills, the quality is stable, the production is mechanized, the degree of automation is high, the output is large, the cost is low, and the hygiene of the medicine is easy to meet the standards; it is a new dosage form that is more convenient to take, carry, and store.
However, due to the various medicinal flavors of Kunbao Pills, it is bound to cause many difficulties in dosage form improvement.

Method used

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  • Chinese medicine solid preparation for treating climacteric syndrome and preparation method thereof
  • Chinese medicine solid preparation for treating climacteric syndrome and preparation method thereof
  • Chinese medicine solid preparation for treating climacteric syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Embodiment 1: Kunbao tablets

[0156] Prescription (kg): Ligustrum lucidum (wine roasted) 3 raspberries 2 Cuscuta 2

[0157] Goji berry 2 Polygonum multiflorum (black bean roasted in wine) 2

[0158] Tortoise shell 1.5 Digupi 3 Nansha ginseng 2

[0159] Ophiopogon japonicus 2 Suanzaoren (stir-fried) 1

[0160] Rehmannia 3 Paeoniae Alba 6 Paeoniae Rubra 3

[0161] Angelica 2 Milletah 6 Mother of Pearl 6

[0162] Dendrobium 3 Chrysanthemum 3 Eclipta 4

[0163] Mulberry leaf 2 Baiwei 3 Anemarrhena 3

[0164] Scutellaria baicalensis 3 (the above mass units are in kilograms)

[0165] Excipients: appropriate amount of microcrystalline cellulose and starch.

[0166] Preparation Process:

[0167] The above twenty-three flavors, Polygonum multiflorum and Radix Paeoniae Alba were crushed into fine powder, and sieved; Ligustrum lucidum, dodder, Digupi, Angelica, Mildew Spatholobus, Anemarrhena,...

Embodiment 2

[0168] Embodiment 2: water pill (compression)

[0169] Prescription: with embodiment 1.

[0170] Preparation Process:

[0171] The above twenty-three flavors, Polygonum multiflorum and Radix Paeoniae Alba are crushed into fine powder, sieved, and set aside; Ligustrum lucidum, Cuscuta, Digupi, Angelica, Mildew Spatholobus, Zhimu plus 75% ethanol for reflux extraction twice, each time 1 hours, filter, combine the filtrates, recycle ethanol until there is no alcohol smell, and concentrate to a clear paste with a relative density of 1.25-1.30 (50°C); the other fifteen flavors such as raspberries are decocted 3 times with water, respectively 2, 1.5, After 1.5 hours, filter, combine the filtrates, concentrate to a clear paste with a relative density of 1.25-1.30 (50°C), combine the above two clear pastes, and dry them into a fine powder; mix with the above two fine powders, add an appropriate amount of water as an auxiliary material , make 1000 grams of water pills, and coat them ...

Embodiment 3

[0172] Embodiment 3: capsules

[0173] Prescription: with embodiment 1. The auxiliary materials are low-substituted hydroxypropyl cellulose and starch.

[0174] Preparation Process:

[0175] The above twenty-three flavors, Polygonum multiflorum and Radix Paeoniae Alba are crushed into fine powder, sieved, and set aside; Ligustrum lucidum, Cuscuta, Digupi, Angelica, Mildew Spatholobus, Zhimu plus 70% ethanol are refluxed twice, each time 1.5 hours, filter, combine the filtrates, recover ethanol until there is no alcohol smell, and concentrate to a clear paste with a relative density of 1.25-1.30 (50°C); the remaining fifteen flavors such as raspberries are decocted with water for 3 times, each time for 1.5 hours, filtered After filtering, the filtrates were combined and concentrated to a clear paste with a relative density of 1.25 to 1.30 (50°C). The above two clear pastes were combined, added with low-substituted hydroxypropyl cellulose and starch, and spray-dried to make gr...

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PUM

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Abstract

The invention provides traditional Chinese medicine solid preparation for treating climacteric syndrome, which comprises traditional Chinese medicine components and medicine accessories. The traditional Chinese medicine components consist of the following raw materials by weight portion: 3 portions of glossy privet fruit, 2 portions of raspberry, 2 portions of dodder, 2 portions of medlar, 2 portions of fleece-flower root, 1.5 portions of tortoise shell, 3 portions of cortex lycii radicis, 2 portions of ladybell root, 2 portions of dwarf lilyturf turber, 1 portion of seed of wild jujube, 3 portions of rehmannia, 6 portions of white paeony root, 3 portions of red paeony root, 2 portions of angelica, 6 portions of caulis milletiae, 6 portions of nacre, 3 portions of dendrobe, 3 portions of chrysanthemum, 4 portions of yerbadetajo, 2 portions of mulberry leaves, 3 portions of radix cynanchi atrati, 3 portions of rhizome anemarrhenae, and 3 portions of scutellaria, wherein the fleece-flower root and the white paeony root are raw powder, and the other 21 traditional Chinese medicines are extracts obtained by extracting raw material crude drugs. The solid preparation overcomes the defect that the prior preparation has large oral dosage, and has good bioavailability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine solid preparation for treating climacteric syndrome and a preparation method thereof, that is, the invention relates to a traditional Chinese medicine solid preparation containing jujube seed, salvia miltiorrhiza and schisandra chinensis and a preparation method thereof. Background technique [0002] Menopausal syndrome is a common clinical disease. At present, the effect of western medicine treatment is not good, and there are certain clinical adverse reactions. Drug residue reactions often occur after taking medicine, which affects mental state, life and work. Among the patients with climacteric syndrome, many patients find it difficult to accept the adverse reactions caused by western medicine. And Chinese medicine has accumulated a large amount of experiences aspect the treatment of menopausal syndrome, and, because Chinese medicine has few adverse reactions to nerve and spirit, it has broad d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/14A61K9/16A61K9/20A61K9/48A61P15/12A61K35/56A61K35/586A61K35/618
Inventor 张维钧薛海晨刘柏刚彭鹏吴炜张丽娟励华夏蓉
Owner BEIJING TONGRENTANG CO LTD
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