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Method for producing shell-core structure medicament nano-fibre with emulsion electrostatic spinning technology

An electrospinning technology and nanofiber technology are applied in the field of preparing shell-core structure drug nanofibers by emulsion electrospinning technology, and achieve the effects of good economic benefits, mild reaction conditions and simple operation.

Inactive Publication Date: 2009-08-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These technologies can control the release of drugs very well. At present, there is no relevant report on nano-drugs using emulsion electrospinning technology to achieve drug control and release.

Method used

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  • Method for producing shell-core structure medicament nano-fibre with emulsion electrostatic spinning technology
  • Method for producing shell-core structure medicament nano-fibre with emulsion electrostatic spinning technology
  • Method for producing shell-core structure medicament nano-fibre with emulsion electrostatic spinning technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 0.5g BSA with an electronic balance, and dissolve it in 10mL ultrapure water, stir and oscillate to dissolve completely to obtain an aqueous phase solution;

[0030] Weigh 0.8g polylactic acid-caprolactone P(LLA-CL)[75:25], 0.05g rhodamine B, and 0.05g SPAN-80 respectively with an electronic balance, dissolve them in 10mL of dichloromethane, stir and oscillate until dissolved Completely, an oil phase solution is obtained;

[0031] Under the condition of stirring, 0.5 mL of aqueous solution was added dropwise to the oil phase solution, and the stirring was continued until a uniform emulsion was obtained. Electrospinning was performed on the obtained emulsion, the applied voltage was 20kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm. The diameter of the obtained nanofiber is between 200nm and 1500nm.

Embodiment 2

[0033] Weigh 0.3g tetracycline hydrochloride with an electronic balance, dissolve it in 10mL ultrapure water, stir and oscillate to dissolve completely to obtain an aqueous phase solution;

[0034] Weigh 0.8g of polylactic acid-caprolactone P(LLA-CL) [50:50], 0.3g of griseofulvin, and 0.05g of sodium dodecylsulfonate with an electronic balance, and dissolve them in 10mL of chloroform , stirred and oscillated until completely dissolved to obtain an oil phase solution;

[0035] Under the condition of stirring, 0.5 mL of aqueous solution was added dropwise to the oil phase solution, and the stirring was continued until a uniform emulsion was obtained. Electrospinning was performed on the obtained emulsion, the applied voltage was 20kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm. The diameter of the obtained nanofiber is between 300nm and 1000nm.

Embodiment 3

[0037] Weigh 0.5g doxorubicin with an electronic balance, dissolve it in 10mL ultrapure water, stir and oscillate to dissolve completely to obtain an aqueous phase solution;

[0038] Weigh 0.8g polylactic acid PLLA, 0.05g paclitaxel, and 0.05g glycerol monooleate respectively with an electronic balance, dissolve them in 10mL of chloroform, stir and oscillate until completely dissolved, and obtain an oil phase solution;

[0039]Under the condition of stirring, 0.5 mL of aqueous solution was added dropwise to the oil phase solution, and the stirring was continued until a uniform emulsion was obtained. Electrospinning was performed on the obtained emulsion, the applied voltage was 20kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm. The diameter of the obtained nanofiber is between 200nm and 1200nm.

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Abstract

The invention relates to a method for preparing shell-core structured medicament nano fiber by emulsion electrostatic spinning technology, comprising dissolving water soluble medicaments or active growth factors in super pure water to prepare uniform water phase solution; (2) dissolving high molecular polymers and oil soluble medicaments in organic solution, and adding emulsifier to prepare uniform oil phase solution; (3) dripping the water solution into the oil phase solution, and completely stirring the mixed solution to obtain uniform water-in-oil type W / O emulsion; and (4) carrying out electrostatic spinning on the emulsion, setting the spinning voltage at 15-25kv, the reception distance at 10-20cm, the spinning pushing speed at 0.5-1.5mL / h, and the spinning nozzle as 0.9mm, and obtaining the target product. The preparation method is simple in operation, mild in reaction condition, low in cost and favorable for economic benefit; and the prepared shell-core composite nano fiber not only has better mechanical property, but also can realize loading of oil soluble medicaments.

Description

technical field [0001] The invention belongs to the field of preparing drug nanofibers with a shell-core structure, in particular to a method for preparing drug nanofibers with a shell-core structure by emulsion electrospinning technology. Background technique [0002] The electrospinning method is to charge the polymer solution under a high-voltage electrostatic field and form a filament during the spraying process to a low electric field, so that ultra-fine uniform fibers with diameters from nanometers to micrometers can be obtained. Electrospinning first appeared in 1934. Formhals first introduced the method of using electrostatic repulsion to obtain polymer filaments in a patent. The principle is to use an external electric field force to make the polymer solution or melt overcome the surface tension in the capillary of the spinning nozzle. The tip forms a jet. When the electric field strength is high enough, under the joint action of electrostatic repulsion, Coulomb and...

Claims

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Application Information

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IPC IPC(8): D01D5/34D01D1/02A61K9/00
Inventor 莫秀梅苏艳李晓强周倩
Owner DONGHUA UNIV
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