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Composite gel film agent

A composite gel and film technology, which can be used in drug combinations, non-active components of polymer compounds, and medical preparations with non-active components, etc. It can solve the problems of excessive decomposition, insufficient strength and toughness, and excessive viscosity. , to achieve the effect of inhibiting the growth of fungi, no residues and toxic side effects, and stable preparations

Inactive Publication Date: 2009-09-09
大连永兴生物医药孵化器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the disadvantages of insufficient strength and toughness, too high or too low viscosity, too fast or too slow decomposition of a single-component film, the present invention provides a compound compound of sodium carboxymethyl cellulose and other gels. gel film

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In the preparation of 1000g treatment burn and scald film:

[0017] (1) 600g sodium carboxymethylcellulose, 100g chitosan, 80g polyvinyl alcohol are mixed evenly;

[0018] (2) Add 10g of glycerin, 10g of Tween-80, and 6000ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0019] (3) Slowly pour 100g of Shaoshangling percolation solution into (2) while stirring, and after stirring evenly, the film raw material is obtained;

[0020] (4) The raw material (3) of the film agent is formed into a film by a film forming machine to prepare a gel film agent for treating burns and scalds.

Embodiment 2

[0022] In the preparation of 1000g treatment eczema, eczema, yellow water sore film agent:

[0023] (1) 450g sodium carboxymethylcellulose, 90g sodium starch glycolate are mixed evenly;

[0024] (2) Add 50 g of glycerin, 10 g of Tween-80, and 5000 ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0025] (3) Slowly pour 400g of Jiusheng San into (2) while stirring, and after stirring evenly, the film raw material is obtained;

[0026] (4) The raw material (3) of the film preparation is formed into a film by a film forming machine to prepare the Jiusheng film preparation for treating eczema, eczema, and yellow water sore.

Embodiment 3

[0028] In the preparation of 1000g treatment bruises, rheumatic arthralgia film:

[0029] (1) Fully mix 440g sodium carboxymethylcellulose and 100g sodium alginate;

[0030] (2) Add 50 g of glycerin, 10 g of Tween-80, and 5000 ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0031] (3) pour the extract solution of 400g Fengshi Dieda Gao into (2) while stirring, and after stirring, the film raw material is obtained;

[0032] (4) The film preparation raw material (3) is formed into a film by a film forming machine to prepare a film preparation for treating bruises and rheumatic arthralgia.

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PUM

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Abstract

The invention relates to a composite gel film agent, which is characterized in that sodium carboxymethyl cellulose and other gels are compounded into film agent matrix. The composite gel film agent has the following advantages that the film agent has hemostasis function, has the function of inhibiting bacteria growth, is more stable, can slowly and durably release components of drug so as to improve curative effect, is convenient to use because the gel film agent can quickly absorb water (tissue fluid) in the anus, vagina or uterus, nasal cavity and auditory meatus to expand and dissolve to generate biological adhesion so that the gel film agent is adhered to the cavity and the film agent drug solution is not easy to flow out and a barrier does not need to be placed at the vagina or the anus due to no outflow, has no stimulation, can be biodegradable in vivo, has no residue or toxic and side effects, and is accepted more easily by a patient under the condition of enhancing curative effect.

Description

technical field [0001] The invention relates to a composite gel film capable of carrying multiple medicines, which is composed of sodium carboxymethyl cellulose and other gels. Background technique [0002] At present, there are two types of film-forming materials commonly used as drug carriers, natural and synthetic polymers. Natural ones include starch, dextrin, cellulose, gelatin, gum arabic, agar, alginic acid, etc.; synthetic polymers include cellulose derivatives, polyvinyl alcohol, polyvinylpyridine, etc. Due to the single composition, there are inevitably disadvantages such as insufficient strength and toughness, too high or too low viscosity, too fast or too slow decomposition, etc. [0003] Usually the used medicament of various medicines for external use is mostly the form of liquid medicine, tincture, ointment. Not only is it inconvenient to store and carry, but also the clothes are polluted and part of the medicament is lost due to the need to smear on the aff...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/36A61K47/34A61K47/32A61K47/40A61K47/42A61K9/70A61P7/04A61P31/04A61K47/10
Inventor 冯伯智滕锡山
Owner 大连永兴生物医药孵化器有限公司
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