Chinese traditional compound medicine preparation for treating hepatitis C and preparation method thereof

Abstract

The invention discloses a Chinese traditional compound medicine preparation for treating hepatitis C and a preparation method thereof. The Chinese traditional compound medicine is prepared by the bulkdrugs with the following weight percentage: 30 to 40 percent of Lysimachia clethroides Duby, 15 to 25 percent of cuchaihu, 15 to 25 percent of Herba Artemisiae Capillaris, 10 to 20 percent of fried radix codonopsitis as well as 5 to 15 percent of liquorice. Pharmacological test and clinical trial show that the Chinese traditional compound medicine has good effects of protecting liver, improving the liver function, and promoting liver cytothesis. Moreover, the Chinese traditional compound medicine has low side effects and low cost. The preparation method for the Chinese traditional compound medicine adopts a supercritical carbon dioxide fluid extraction technology which has the advantages of less organic solvent, high extraction and separation efficiency, strong maneuverability, low production cost and being suitable for industrial production.

Description

technical field [0001] The invention relates to a medicine, in particular to a compound traditional Chinese medicine preparation, a preparation method thereof and an application of the compound traditional Chinese medicine preparation for preparing a compound traditional Chinese medicine preparation for treating viral hepatitis. Background technique [0002] Hepatitis C is a kind of viral hepatitis, mainly caused by liver damage. Hepatitis C is a disease mainly transmitted by blood. Chronic infection of hepatitis C virus can lead to chronic inflammation, necrosis and fibrosis of the liver, and some patients may develop Liver cirrhosis or even hepatocellular carcinoma is extremely harmful to the health and life of patients, and has become a serious social and public health problem. [0003] my country is one of the countries with a high incidence of viral hepatitis in the world. Among the more than 2 million new cases of acute hepatitis each year, hepatitis C patients accoun...

AI Technical Summary

Problems solved by technology

[0003] my country is one of the countries with a high incidence of viral hepatitis in the world. Among the more than 2 million new cases of acute hepatitis each year, hepatitis C patients account for 5% to 10%. There are no completely effective treatment methods and specific drugs. The clinical first-line drug interferon is currently the first choice for the treatment of hepatitis C, but the effect of interferon drugs is limited. The complete response rate in 6 months is only about 45%, and the durable response rate is only 20%, and many side effects, expensive, difficult to popularize and use

At the same time, the disease of hepatitis C is spreading rapidly, so the current marketed drugs still fail to meet the needs of hospitals and patients

[0004] Traditional Chinese medicine extraction methods often use water extraction, alcohol extraction, alkaline water or acid water extraction. After the crude product is separated, it is mainly based on its polarity, acidity, and molecular weight. Or special structure and properties, using suitable separation methods for separation and purification, the main disadvantages are the large amount of organic solvent used, and the extraction of active ingredients is not complete, the loss of active ingredients in the process of separation and purification is large, the cost is high, and the operation is inconvenient, etc.