Method for preparing biodegradable blood vessel external scaffold material used in tissue engineering
A technology of tissue engineering and scaffold materials, which is applied in the field of preparing biodegradable tissue engineering vascular outer layer scaffold materials, can solve the problems of poor mechanical properties and fast degradation rate of scaffold materials, and achieve excellent immunocompatibility and immune rejection The effect of low reaction and elimination of virus hazards
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Embodiment 1
[0023] Dissolve human-like collagen with distilled water into a 1.0% solution, and dissolve chitosan with a degree of deacetylation of 60% and a molecular weight of 400,000 daltons into a 1.0% solution with 0.5% acetic acid, and then press the two to 5 :1 (mass ratio) mix, add 0.4% of the total solution of glycerol, stir evenly, then add 40μL of 25% glutaraldehyde aqueous solution, gently stir for 30min, after filtering, vacuum degassing, pour into the tubular mold, 4 After being cross-linked at ℃ for 2 days, it was placed in a refrigerator at -80℃ for 5h to form, and vacuum dried at -10℃ to form an intravascular stent. After washing 5 times with distilled water, it was again freeze-dried and formed. 60 Standby after disinfection.
Embodiment 2
[0025] Dissolve human-like collagen with distilled water into a 2.0% solution, dissolve chitosan with a degree of deacetylation of 70% and a molecular weight of 450,000 daltons into a 1.5% solution with 0.5% acetic acid, and then press the two :1 (mass ratio) mix, add 0.4% of the total solution of glycerol, stir evenly, then add 20μL of 50% glutaraldehyde aqueous solution, gently stir for 30min, after filtering, vacuum degassing, pour into the tubular mold, 4 After being cross-linked at ℃ for 2 days, it was placed in a refrigerator at -80℃ for 5h to form, and vacuum dried at -10℃ to form an intravascular stent. After washing 5 times with distilled water, it was again freeze-dried and formed. 60 Standby after disinfection.
Embodiment 3
[0027] Dissolve human-like collagen with distilled water into a 1.0% solution, dissolve chitosan with a degree of deacetylation of 80% and a molecular weight of 500,000 Daltons into a 0.5% solution with 0.5% acetic acid, and then press the two :1 (mass ratio) mix, add 0.4% of the total solution of 1.3-butanediol, stir evenly, then add 40μL of 25% glutaraldehyde aqueous solution, gently stir for 30min, after filtering, vacuum degassing, inject into the tubular mold After cross-linking at 4°C for 3 days, it was placed in a -80°C refrigerator for 5h to form, and vacuum dried at -10°C to form an intravascular stent. After washing with distilled water for 5 times, it was again freeze-dried and molded. 60 Standby after disinfection.
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