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Preparation method of orthopaedics inner fixing apparatus based on polyhydroxyalkanote material

A technology of polyhydroxyalkanoate and hydroxycaproate, which is applied in the fields of medical science, household components, and applications, can solve the problems of delayed fracture healing, complicated operation steps, tissue inflammation, etc., and achieves a simple, easy-to-operate, hydrophilic method. Good sex and strong cell adhesion

Inactive Publication Date: 2012-01-25
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in use, metal internal fixation materials have the following disadvantages: they are prone to electrolytic corrosion in a body fluid environment, producing metal ions, causing local tissue inflammation; metals are prone to stress shielding, resulting in delayed fracture healing; secondary surgery is required to remove, increasing Reduced surgical costs and patient suffering
The disadvantage of this preparation method is that the operation steps are complicated, and at the same time, there will be residual organic solvents in the sample, which will have a toxic effect on orthopedic implant materials after they are implanted into the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The invention provides a method for preparing an orthopedic internal fixation device based on a polyhydroxyalkanoate material, comprising the following steps:

[0019] In the drying treatment step, polyhydroxyalkanoate is used as the main ingredient and inorganic materials are used as additives, and the above-mentioned main ingredients and additives are subjected to vacuum drying treatment to remove the moisture contained therein;

[0020] In the blending step, the dried main material and the additive are blended according to a predetermined mass ratio;

[0021] In the injection molding step, the mold of the orthopedic internal fixation device is used for injection molding processing on a micro-injection molding machine, and the barrel temperature of the injection molding machine is higher than the melting temperature of the blend;

[0022] In the post-processing step, after the injection molding is completed, the mold with the injection molded part is cooled and demoul...

example 1

[0030] Put the polyhydroxybutyrate-hydroxycaproate as the main ingredient and the hydroxyapatite as the additive into a vacuum drying oven to dry for 4 hours to remove the moisture in the raw material; then, according to the main ingredient: additive = 99 : 1 mass ratio ratio, the main material and the additive are blended; then, the specially processed molds for internal fixation bone screws, bone plates and intervertebral cages are selected and placed on a micro-injection molding machine, and then the blend Add it to the injection molding machine for injection molding. During injection molding, the temperature of the barrel is 5°C higher than the melting temperature of the blend through temperature control. The screw speed in the injection molding machine is 75rpm, and the holding time is 5min. After the injection molding is completed, the mold is cooled to Open the mold at room temperature to take out the injection molded part, and obtain a degradable orthopedic internal fix...

example 2

[0032] Put the poly-3-hydroxybutyrate-4-hydroxybutyrate-hydroxyhexanoate as the main material and the bioglass as the additive into a vacuum drying oven to dry for 5 hours to remove the moisture in the raw materials; then, according to the main Material: additives = 95:5 mass ratio, the main material and additives are blended; then, the specially processed molds for internal fixation bone screws, bone plates and intervertebral cages are selected and placed on a micro-injection molding machine , and then put the blend into the injection molding machine for injection molding. During injection molding, the temperature of the barrel is 10°C higher than the melting temperature of the blend. The screw speed in the injection molding machine is 75rpm, and the holding time is 8min; After the mold is cooled to room temperature, the mold is opened and the injection molded part is taken out, and the degradable orthopedic internal fixation device is obtained after trimming.

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PUM

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Abstract

The invention relates to a preparation method of an orthopaedics inner fixing apparatus based on a polyhydroxyalkanote material, which comprises the following steps: drying and treating: respectively carrying out vacuum drying treatment on polyhydroxyalkanote as a main material and an inorganic material as an addition material to remove water; blending: carrying out blending and processing on themain material and the addition material which are subject to drying treatment according to the preset mass ratio; injection molding: carrying out injection, molding and processing on a miniature injection machine by using the orthopaedics inner fixing apparatus to ensure that the temperature of a material cylinder is higher than the melting temperature of blend; and post treatment: demolding a mold after the mold is cooled, and carrying out surface finishing to obtain a degradable orthopaedics inner fixing apparatus. The orthopaedics inner fixing apparatus is a bone nail, a bone plate or a vertebral fusion device. The preparation method takes the polyhydroxyalkanote as the main material and the inorganic material as the addition material, combines blending processing and miniature injection processes and is convenient and easy to operate; and the orthopaedics inner fixing apparatus has favorable mechanical strength without hurting human bodies.

Description

technical field [0001] The invention relates to a preparation method of an orthopedic internal fixation device, in particular to a preparation method of an orthopedic internal fixation device based on a polyhydroxyalkanoate material. Background technique [0002] Orthopedic diseases are frequent diseases in modern society. Orthopedic diseases represented by spinal diseases, joint diseases, osteoporosis, bone tumors and fractures caused by external forces such as car accidents are relatively common cases in hospitals. The main treatment for fractures is to butt and fix the broken bones with the help of external force, and rely on the reconstruction function of bone cells to fill the cracks and reconnect them into a whole. At present, there are three types of orthopedic internal fixation materials commonly used: metal materials, inorganic bioceramic materials and degradable polymer materials. For internal fixation materials, it is not only required that the fixation materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C45/00B29C45/17B29B13/06A61L31/12A61L31/14C08L67/04C08K3/32C08K3/04B29B7/00B29C45/78A61L31/06A61L31/02B29L31/00
Inventor 王臻刘伟强胡庆柳尚鹏廖振华佘振定
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN