Production method of water-soluble hemostatic gauze

A production method and technology of hemostatic gauze, which is applied in the field of production of water-soluble hemostatic gauze, can solve the problems of unsafe products, inability to use, and insufficient strength, etc., achieve no cytotoxic reaction and side effects, prevent surgical adhesion, and facilitate acceleration The effect of rehabilitation

Active Publication Date: 2010-01-13
宁波恒达医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin sponge, gelatin fiber, artificial water-soluble mixed coating, etc., which can barely be used as auxiliary products, cannot completely replace medical gauze due to either poor hemostatic function or insufficient strength
In recent years, some people have envisioned the production of water-soluble hemostatic fiber, but it is still difficult to apply it in practice due to the shortcomings of complicated process, long reaction time, high production cost, and unsafe raw materials.
Such as Chinese patent CN1286329 provides a kind of water-soluble hemostatic fiber and preparation method thereof, but, according to the production process of this patent embodiment 1,3,5,6, find that the product produced has fiber agglomeration, yellowing, texture Hard and other shortcomings, and throug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Gauze pretreatment:

[0048] 1.1 Preparation materials: 1200 grams of cotton gauze, 4800 ml of 95% (v / v) ethanol solution.

[0049] 1.2 Pretreatment: Put the raw material of cotton gauze into a glass container, let the gauze spread out as much as possible, do not overlap, then slowly pour ethanol along the wall of the glass container, tamp it with a glass rod, so that the gauze is completely soaked, and then use a silicone plug Seal for 1 hour.

[0050] 2. Microcrystalline treatment of gauze:

[0051] 2.1 Preparation of microcrystallization reaction solution: use sodium hydroxide to analyze pure crystals and distilled water to prepare 4800ml of 40wt% sodium hydroxide solution, stir with a glass rod until it is completely dissolved and becomes clear and transparent. The liquid was cooled to 20°C and sealed for later use.

[0052] 2.2 Put the pretreated gauze raw material in a circulating rotary reactor, then add 4800ml of the prepared microcrystallization reaction ...

Embodiment 2

[0063] In the microcrystallization treatment, 50 wt% sodium hydroxide solution was selected, and other operations were the same as in Example 1. The obtained water-soluble hemostatic gauze has a mass per unit area of ​​95g / m 2 , 25ml per gram of water absorption, and other test results are the same as in Example 1.

Embodiment 3

[0065] In the cross-linking reaction, 60 wt% ethanol solution of chloroacetic acid was selected, and other operations were the same as in Example 1. The obtained water-soluble hemostatic gauze has a mass per unit area of ​​80g / m 2 , 30ml per gram of water absorption, and other test results are the same as in Example 1.

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PUM

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Abstract

The invention discloses a production method of water-soluble hemostatic gauze. The production method comprises the following steps: carrying out sterilizing process on natural full-cotton gauze after preprocessing, sitallization processing, cross linking reaction, washing and drying, wherein the preprocessing is realized by modifying the natural full-cotton gauze by using ethanol or acetone; the sitallization processing is carried out for 1-2h by adopting a sodium hydroxide solution under the condition that the temperature is 20-30 DEG C and the rotational speed of a reaction vessel is 15-20 r/min; and the cross linking reaction is carried out for 1-2h at the temperature of 25-30 DEG C by adopting an ethanol chloroactic acid solution. The water-soluble hemostatic gauze has favorable functions of physical hemostasis, chemical hemostasis and physiological hemostasis, can rapidly realize hemostasis and diminish inflammation without medicaments, also prevent operation conglutination and be finally decomposed in the body to form monosaccharide absorbed by a human body.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to a method for making water-soluble hemostatic gauze. Background technique [0002] With the rapid development of health care and medicine, the requirements for medical equipment are gradually developing in the direction of high, refined and beautiful. Medical gauze is an important commonly used medical dressing, which has the characteristics of large usage and wide application. However, when it comes to various departments such as surgery, facial features, gynecology, and burns, many problems and accidents caused by conventional gauze cannot be solved for a while, such as repeated infection of the dressing, exacerbating the suffering of patients due to dressing changes, and the negligence of medical staff. Cause the viscera to be left behind and become a serious disaster, the environmental pollution of discarded pus and blood gauze and so on. Therefore, the international medical ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/62A61F13/02D06M14/04D06M11/38D06M13/236D06M13/144D06M13/127D06M101/06
Inventor 黄艇
Owner 宁波恒达医疗器械有限公司
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