Chitosan-polylactic acid graft copolymer and preparation method and application thereof

A technology of graft copolymer and chitosan, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences, etc., can solve the problems of biotoxicity, complex process routes, and insolubility of polymers, and achieve excellent results. The effect of biocompatibility, good biocompatibility, good mechanical properties

Inactive Publication Date: 2010-01-20
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since chitin or chitosan is suspended in toluene, it cannot form a homogeneous reaction system with lactide, the grafting rate of the copolymer is low, and it cannot be dissolved in common solvents for polylactic acid
(3) Coupling macromolecular method: Utilize end-formylation polylactic acid oligomer and chitosan coupling to prepare chitosan-polylactic acid copolymer, adopt this method to introduce polylactic acid with molecular weight definite, but the process route is more complicated ( Chines

Method used

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  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof
  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof
  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Under the catalysis of CCL, chitosan with a degree of deacetylation of 90% and lactide 1:10 (this is the molar ratio of the unit sugar ring number of chitosan to the lactide monomer, the same below).

[0034] Add 0.1118g of chitosan, 1.0000g of lactide and 0.0050g of CCL (put into a bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 90°C, increase the pressure in the reactor and control it at 40MPa, start recording the reaction time, and the reaction ends after 24 hours; continue to keep the pressure in the reactor at 40MPa and the temperature at 90°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 3h, r...

Embodiment 2

[0038] Implementation of 1:0.1 chitosan and lactide with a degree of deacetylation of 95% under PPL catalysis.

[0039] Add 5.5910g of chitosan, 0.5000g of lactide and 0.0500g of PPL (put into a bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 60°C, increase the pressure in the reactor and control it at 25MPa, start recording the reaction time, and the reaction ends after 72 hours; continue to keep the pressure in the reactor at 25MPa and the temperature at 60°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 2h, reduce the pressure of the reactor to atmospheric pressure, and then open the reaction The graft...

Embodiment 3

[0041] Implementation of 1:1 chitosan and lactide with a deacetylation degree of 90% under PPL catalysis.

[0042] Add 1.1182g of chitosan, 1.000g of lactide and 0.0200g of PPL (put into the bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 80°C, increase the pressure in the reactor and control it at 30MPa, start recording the reaction time, and the reaction ends after 24 hours; continue to keep the pressure in the reactor at 30MPa and the temperature at 80°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 4h, reduce the pressure of the reactor to atmospheric pressure, and then open the reaction The graft cop...

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Abstract

The invention provides a chitosan-polylactic acid graft copolymer and a preparation method and an application thereof; the preparation method is to adopt supercritical carbon dioxide fluid as reaction medium and lipase as catalyst to perform graft copolymerization between chitosan or derivative thereof and lactide monomer. The invention is simple to operate, the products are easy to separate, no organic solvent is used in the preparation and purification of the copolymer, the method has no pollution to the environment, and the obtained copolymer has excellent biocompatibility and good mechanical properties so that the copolymer can be used as body-implanted biological materials such as the scaffold for tissue engineering, the carrier for self-assemble micelle drugs, blood compatible material and the like.

Description

technical field [0001] The invention relates to biodegradable medical materials, in particular to a chitosan-polylactic acid graft copolymer and its preparation method and application. Background technique [0002] Polylactic acid has good mechanical and molding properties, biocompatibility and biodegradability, and has been widely used in the field of biomedicine. However, polylactic acid materials are hydrophobic, have poor cell affinity, and the degradation products are acidic, which easily triggers sterile inflammatory reactions and is not conducive to cell growth. [0003] Chitosan is a partial deacetylation product of chitin, a natural polysaccharide with extremely rich sources, non-toxic, non-irritating, good biocompatibility and biodegradability, with free amino groups in its molecule, It is weakly alkaline and can effectively adjust the pH value of the human body; it also has certain physiological activities, which can not only improve the activity and phagocytosis...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08G63/685C08G63/82A61L27/20A61K47/36
CPCY02P20/54
Inventor 罗丙红程松周长忍
Owner JINAN UNIVERSITY
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