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Moguisteine dispersible tablet and preparation method thereof

A technology for dispersible tablets within minutes, applied in the field of mogisteine ​​dispersible tablets and its preparation, can solve the problems of low bioavailability and low solubility of oral solid preparations, achieve the goals of reducing adverse reactions, simple production process, and improving solubility Effect

Inactive Publication Date: 2010-02-03
广州达信生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the low solubility of mogisteine ​​in water easily leads to low bioavailability of the oral solid preparation

Method used

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  • Moguisteine dispersible tablet and preparation method thereof
  • Moguisteine dispersible tablet and preparation method thereof
  • Moguisteine dispersible tablet and preparation method thereof

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preparation example Construction

[0030] In another aspect, the present invention provides a method for preparing mogisteine ​​dispersible tablets, which comprises the following steps: (1) mixing 5 parts by weight to 45 parts by weight of mogisteine, 10 parts by weight to 50 parts by weight The disintegrant, the filler of 20 parts by weight-80 parts by weight and the flavoring agent of 0.5 parts by weight-3.0 parts by weight are mixed to prepare a premix; (2) Add 0.5 parts by weight to 2.5 parts by weight of (3) granulating the obtained soft material; (4) drying the obtained granules; (5) sizing the dried granules; (6) adding 0.4 parts by weight to 1.5 parts by weight of Lubricants are blended and tabletted.

[0031] The preparation method of the present invention preferably further includes: before step (1), passing the mogisteine ​​raw material through a 100-mesh sieve, and passing the disintegrating agent, filler, flavoring agent and lubricant through a 60-80 mesh sieve .

[0032] In the preparation metho...

Embodiment 1

[0050] First, pass the main ingredient of mogisteine ​​through a 100-mesh sieve, and pass the excipients (including disintegrant sodium carboxymethyl starch, filler mannitol, flavoring agent aspartame and lubricant magnesium stearate) through a 60-mesh sieve. -80 mesh sieve.

[0051] Then, take by weighing 25g mogisteine, 50g sodium starch glycolate, 100g mannitol and 1.0g aspartame respectively, they are mixed by equal increment method, in the gained mixture, add 40ml of 3% (weight / volume) ethanol solution of povidone to make soft materials, pass through a 24-mesh sieve to granulate, and then air-dry at 40°C.

[0052] The dried granules are passed through a 24-mesh sieve for granulation, 1.6 g of magnesium stearate is added thereto, mixed evenly, and compressed into tablets to obtain the mogisteine ​​dispersible tablet of the present invention.

[0053] Measure according to the method described in the two appendices of "Chinese Pharmacopoeia" (2005 edition), the disintegrat...

Embodiment 2

[0055] Prepare mogistein dispersible tablet according to the method described in embodiment 1, difference is to take by weighing 50g mogistein as main ingredient, take by weighing 20g cross-linked carmellose sodium and 50g cross-linked povidone As a disintegrant, weigh 80g mannitol and 100g pregelatinized starch as filler, weigh 1.2g aspartame as flavoring agent, and use 60ml of 5% (weight / volume) povidone ethanol solution as Binder, 3 g magnesium stearate as lubricant.

[0056] According to the method measurement described in the two appendices of "Chinese Pharmacopoeia" (2005 edition), the disintegration time limit of the dispersible tablet in this embodiment is 1.1 minutes.

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Abstract

The invention relates to a moguisteine dispersible tablet and a preparation method thereof. The moguisteine dispersible tablet comprises the following components in portion by weight: 5 to 45 portionsof moguisteine, 10 to 50 portions of disintegrating agent, 20 to 80 portions of filling agent, 0.5 to 3.0 portions of flavouring agent, 0.4 to 1.5 portions of lubricating agent, and 0.5 to 2.5 portions of binding agent. The moguisteine dispersible tablet has the advantages of high dissolubility, quick response, quick release, obvious effect, conclusive curative effect and the like. The moguisteine dispersible tablet can be applied to cough relief.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a mogisteine ​​dispersible tablet and a preparation method thereof. Background technique [0002] Coughing is an important reflex protection mechanism. Coughing can expel sputum and foreign objects in the respiratory tract, protect the cleanliness and smoothness of the respiratory tract, and prevent infection. However, if the severe cough persists, not only the patient suffers, but also other complications are likely to occur. With the aging of society and the aggravation of environmental pollution, the incidence of respiratory diseases continues to rise. Expectorant and antitussive drugs will be an important part of respiratory system drugs, so it is necessary to choose appropriate antitussives to relieve cough. [0003] Moguisteine ​​(moguisteine) is an acetylcholine antagonist developed by Swiss Roche Company, a peripheral non-narcotic antitussive drug, which has no effect on the cent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/426A61P11/14
Inventor 陈宝林雍智全阴元魁陈皓赖观平韩为跃闻亚磊
Owner 广州达信生物技术有限公司
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