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A compound slow-release preparation of guaiacol and pseudoephedrine

A technology of guaiacol glycerol ether and pseudoephedrine, which is applied in the field of medicine and achieves the effects of small fluctuation, reduction of taking times and stable blood drug concentration

Active Publication Date: 2011-12-07
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific treatment at all, it is not necessary for the virus to be firm, and only symptomatic treatment can be used to relieve many symptoms of the common cold

Method used

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  • A compound slow-release preparation of guaiacol and pseudoephedrine
  • A compound slow-release preparation of guaiacol and pseudoephedrine
  • A compound slow-release preparation of guaiacol and pseudoephedrine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] Guaifenesin 800g Pseudoephedrine Hydrochloride 90g Hypromellose E5 40g carnauba wax 25g microcrystalline cellulose 36g Povidone K 30 aqueous solution Appropriate amount Magnesium stearate Appropriate amount

[0029] Coating prescription:

[0030] Opadry 15g pure water Add to 100ml

[0031] Preparation:

[0032] (1) Preparation of granules Hypromellose E5 and microcrystalline cellulose were sieved respectively, mixed evenly with guaiacol glyceryl ether, pseudoephedrine hydrochloride and carnauba wax, and mixed with 5% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0033] (2) Preparation of coating liquid Add Opadry to pure water, and add pure water to 100ml, stir for 1 hour, set aside.

[0034] (3) Coating the granules of (1) to ...

Embodiment 2

[0043] prescription:

[0044] Guaifenesin 400g Pseudoephedrine Hydrochloride 60g Hypromellose K100 6g Hypromellose E5 75g

[0045] microcrystalline cellulose 45g Povidone K 30 aqueous solution Appropriate amount stearic acid Appropriate amount

[0046] Coating prescription:

[0047] Pseudoephedrine Hydrochloride 30g Opadry 25g water Appropriate amount until completely dissolved

[0048] Preparation:

[0049] (1) Preparation of granules Hypromellose and microcrystalline cellulose are sieved respectively, mixed and evenly mixed, then mixed evenly with guaiacol glyceryl ether and pseudoephedrine hydrochloride, and mixed with 8% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0050] (2) Preparation of coating solution Dissolve pseudoephedrine hydroch...

Embodiment 3

[0060] prescription:

[0061] Guaifenesin 600g pseudoephedrine sulfate 60g pregelatinized starch 110g Sodium carboxymethyl starch 20g Hypromellose K4 7g Hydroxyethyl cellulose 72g microcrystalline cellulose 60g carnauba wax 50g Povidone K 30 aqueous solution Appropriate amount talcum powder 20g

[0062] Coating prescription:

[0063] Opadry II 30g pure water 1000ml

[0064] Preparation:

[0065] (1) Each component in the prescription is passed through a 100-mesh sieve respectively, and set aside;

[0066] (2) Preparation of immediate-release granules: Fully mix the prescription amount of pregelatinized starch and 1 / 2 amount of sodium carboxymethyl starch, mix evenly with guaiacol glyceryl ether, and mix with 5% povidone K 30 The aqueous solution is a soft material made of adhesive, 20-mesh sieve is used to make wet granules, air-dried at 50°C, granulated with 20-mesh sieve, 1 / 2 amount...

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Abstract

The invention relates to a slow-release preparation with guaiacol glycerin, pseudoephedrine or physiologically acceptable salts thereof as active ingredients. Provided is a compound preparation capable of overcoming cold-related symptoms, and in which all active ingredients are released in a sustained manner.

Description

technical field [0001] The invention relates to a sustained-release preparation with guaiacol glycerin, pseudoephedrine or a physiologically acceptable salt thereof as active components, and belongs to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and myalgia. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects to relieve different symptoms that exist at the same time. If the patient h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/09A61K9/28A61K31/137A61P11/00A61P31/12
Inventor 郑顺利
Owner 北京科信聚润医药科技有限公司
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