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Carteolol orally disintegrating tablets and preparation method thereof

A technology of orally disintegrating tablets and hydrochloric acid cards, which is applied in the field of pharmaceutical preparations, can solve the problems that have not yet been reported on carteolol hydrochloride orally disintegrating tablets, and achieve the effects of good medication compliance, convenient taking, and broad market prospects

Inactive Publication Date: 2010-04-07
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no research report on carteolol hydrochloride orally disintegrating tablets

Method used

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  • Carteolol orally disintegrating tablets and preparation method thereof
  • Carteolol orally disintegrating tablets and preparation method thereof
  • Carteolol orally disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] prescription

[0047]

[0048] manufacturing method Pulverize all the components in the prescription into fine powder with a fineness of more than 100 meshes; 5g carteolol hydrochloride, 45g lactose, 21.5g microcrystalline cellulose, 3.5g low-substituted hydroxypropyl cellulose, 3g citric acid , 0.02 g of sodium saccharin and 0.5 g of menthol were mixed, and 4% povidone K30 solution was added to make a soft material, granulated with a 24-mesh sieve, dried at 50 °C, and the dry granules were sieved through a 24-mesh sieve to granulate; Add 21.5 g of microcrystalline cellulose, 3.5 g of low-substituted hydroxypropyl cellulose, 1 g of sodium bicarbonate and 0.5 g of magnesium stearate to the dry granules, mix well, and press into tablets to make carteolol hydrochloride orally disintegrating. Dissolve 1000 tablets, each tablet contains carteolol hydrochloride 5mg.

[0049] quality The obtained orally disintegrating tablet has a smooth and glossy appearance; it ...

Embodiment 2

[0051] prescription

[0052]

[0053] manufacturing method Pulverize all the components in the prescription into fine powder with a fineness of more than 100 meshes; 5 g of carteolol hydrochloride, 15 g of mannitol, 15 g of lactose, 22.5 g of microcrystalline cellulose, 5 g of low-substituted hydroxypropyl cellulose, 9 g of tartaric acid, 0.02 g of sodium saccharin and 2.5 g of menthol were mixed, and 4% povidone K30 solution was added to make a soft material, granulated with a 24-mesh sieve, dried at 50°C, and the dried granules passed through a 24-mesh sieve to granulate ; Add 22.5 g of microcrystalline cellulose, 5 g of low-substituted hydroxypropyl cellulose, 3 g of sodium bicarbonate and 0.5 g of magnesium stearate to the dry granules, mix well and press into tablets to make carteolol hydrochloride oral cavity 1000 disintegrating tablets, each containing carteolol hydrochloride 5mg.

[0054] quality The obtained orally disintegrating tablet has a smooth and g...

Embodiment 3

[0056] prescription

[0057]

[0058] manufacturing method All components in the prescription were pulverized into fine powder with a fineness of more than 100 meshes; carteolol hydrochloride 5g, mannitol 57g, lactose 16g, microcrystalline cellulose 5.5g, low-substituted hydroxypropyl cellulose 1g, 7g of citric acid, 0.02g of sodium saccharin and 2.5g of menthol were mixed, and 4% povidone K30 solution was added to make a soft material, granulated with a 24-mesh sieve, dried at 50°C, and the dry granules were sieved through a 24-mesh sieve. Then add 5.5g of microcrystalline cellulose, 1g of low-substituted hydroxypropyl cellulose, 4g of sodium bicarbonate and 0.6g of magnesium stearate to the dry granules, mix well and press into tablets to make carteolol hydrochloride. 1000 orally disintegrating tablets, each containing carteolol hydrochloride 5mg.

[0059] quality The obtained orally disintegrating tablet has a smooth and glossy appearance; completely disintegra...

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Abstract

The invention discloses carteolol orally disintegrating tablets and a preparation method thereof. The orally disintegrating tablets comprise the following compositions in percentage by mass: 0.1 to 10 percent of carteolol, 50 to 90 percent of filler, 5 to 40 percent of disintegrating agent, 0.1 to 5 percent of lubricant and 0.1 to 5 percent of flavoring agent. The orally disintegrating tablets can be quickly disintegrated in oral cavity, has quick absorption, quick response, small first-pass effect of the liver, high biological utilization rate and small irritation on gastrointestinal tract, is convenient for taking, has excellent taste and is particularly suitable for old people, children and patients with swallow difficulty or drinking inconvenience. The orally disintegrating tablets are prepared by adopting a wet granulation and tableting method or a direct powder tableting method, have simple manufacture process, low cost, easily controlled quality, stable preparation, safety and efficiency, are applicable to large-scale industrial production and have wide market prospect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a carteolol hydrochloride oral disintegrating tablet, and also to a preparation method of the oral disintegrating tablet. Background technique [0002] Tablet is a traditional pharmaceutical dosage form, which has become one of the most commonly used pharmaceutical dosage forms at present because of its advantages of stable quality, accurate dosage, convenient taking and carrying, high degree of mechanization, and low production cost. Slow disintegration, low bioavailability, and difficulty in swallowing for some patients are limited in application to a certain extent. To this end, oral solid immediate-release preparations have become one of the hotspots in the research and development of new drugs in recent years, and oral disintegrating tablets, dispersible tablets and sublingual tablets are emerging. Orally disintegrating tablet is a kind of tablet that can disintegrate or diss...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4704A61K47/38A61K47/36A61P27/06A61P9/12A61P9/06A61P9/10A61P9/00
Inventor 罗永煌聂延君乔彦茹田朋鑫刘艳玲雷曙光陈君罗雷
Owner SOUTHWEST UNIVERSITY
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