Unlock instant, AI-driven research and patent intelligence for your innovation.

Organic/inorganic hybridized microcapsule prepared in biomimetic way by simulated body fluid method and preparation method thereof

A technology for simulating body fluids and microcapsules, applied in biochemical equipment and methods, chemical instruments and methods, microsphere preparation, etc., can solve the problems of expensive and toxic precursors, and improve mechanical strength and operational stability. Good reproducibility and mild preparation conditions

Inactive Publication Date: 2010-04-14
TIANJIN UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the sol-gel method is the most common method, which can avoid phase separation caused by high temperature treatment, allow doping a large amount of organic and inorganic substances, and easily obtain high-purity and high-uniform materials, but the precursors are expensive And poisonous, acid (or base) catalyst also limits its wide application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Organic/inorganic hybridized microcapsule prepared in biomimetic way by simulated body fluid method and preparation method thereof
  • Organic/inorganic hybridized microcapsule prepared in biomimetic way by simulated body fluid method and preparation method thereof
  • Organic/inorganic hybridized microcapsule prepared in biomimetic way by simulated body fluid method and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation containing simulated body fluid (I), the specific composition is: 134.0mmol / L Na + , 5.0mmol / L K + , 30.0mmol / LCa 2+ , 3.0mmol / L Mg 2+ , 258.0mmol / L Cl - , 0.5mmol / L SO 4 2- . Prepare simulated body fluid (II), the specific composition is 350.0mmol / L Na + , 5.0mmol / L K + , 8.4mmol / L HCO 3 - , 148.0mmol / L Cl - , 50.0mmol / LHPO 4 2- , 0.5mmol / L SO 4 2- .

[0022] Sodium alginate was dissolved in simulated body fluid (II) to prepare a solution containing 1.0% sodium alginate mass fraction. Chitosan is dissolved in simulated body fluid (I) to prepare a solution containing chitosan with a mass fraction of 0.5%. At room temperature, use a 5ml syringe with a needle tube diameter of 0.5mm to drop the prepared sodium alginate solution in the chitosan solution, and the small droplet is taken out after chitosan is dissolved in the simulated body fluid (I) and preserved for 20 minutes, and then Rinse in distilled water. All steps were performed at room ...

Embodiment 2

[0024] Preparation containing simulated body fluid (I), the specific composition is: 134.0mmol / L Na + , 5.0mmol / L K + , 60.0mmol / LCa 2+ , 3.0mmol / L Mg 2+ , 258.0mmol / L Cl - , 0.5mmol / L SO 4 2- . Prepare simulated body fluid (II), the specific composition is 350.0mmol / L Na + , 5.0mmol / L K + , 8.4mmol / L HCO 3 - , 148.0mmol / L Cl - , 100.0mmol / L HPO 4 2- , 0.5mmol / L SO 4 2- .

[0025] Sodium alginate was dissolved in simulated body fluid (II) to prepare a solution containing 2.0% sodium alginate mass fraction. Chitosan was dissolved in simulated body fluid (I) to prepare a solution containing chitosan with a mass fraction of 0.8%. At room temperature, the prepared sodium alginate solution was added dropwise to the chitosan solution with a 5ml syringe with a needle diameter of 0.9 mm to prepare polysaccharide microcapsules biomimetic mineralized with hydroxyapatite. The small droplets were removed after 30 min in chitosan dissolved in simulated body fluid (I) and r...

Embodiment 3

[0027] Preparation containing simulated body fluid (I), the specific composition is: 134.0mmol / L Na + , 5.0mmol / L K + , 120.0mmol / LCa 2+ , 3.0mmol / L Mg 2+ , 258.0mmol / L Cl - , 0.5mmol / L SO 4 2- . Prepare simulated body fluid (II), the specific composition is 350.0mmol / L Na + , 5.0mmol / L K + , 8.4mmol / L HCO 3 - , 148.0mmol / L Cl - , 200.0mmol / L HPO 4 2- , 0.5mmol / L SO 4 2- .

[0028]Sodium alginate was dissolved in simulated body fluid (II) to prepare a solution containing 3.0% sodium alginate mass fraction. Chitosan was dissolved in simulated body fluid (I) to prepare a solution containing chitosan with a mass fraction of 1.2%. At room temperature, the prepared sodium alginate solution was added dropwise to the chitosan solution with a 5ml syringe with a needle diameter of 1.5 mm to prepare polysaccharide microcapsules biomimetic mineralized with hydroxyapatite. Droplets were removed after 50 min of chitosan dissolved in simulated body fluid (I) and rinsed in d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
quality scoreaaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention relates to an organic / inorganic hybridized microcapsule prepared in biomimetic way by simulated body fluid method and a preparation method thereof. In simulated body fluid, the hybridized microcapsule is prepared by adopting sodium alga acid and chitosan as raw materials, wherein the mass percent of sodium alga acid solution is 1.0%-3.0% and the mass percent of chitosan solution is 0.5%-1.2%. The simulated body fluid solution of the sodium alga acid reacts with the simulated body fluid solution of the chitosan, which contains Ca 2+ ions, to produce a hydroxyapatite biomimetic-mineralized polysaccharose microcapsule, placing in the chitosan solution and then washing with water. The invention has the advantages of simple and convenient operation and gentle reaction condition, uniform prepared hybridized microsphere, good stability, and excellent repeatability.

Description

Technical field: [0001] The invention relates to the preparation of composite materials, in particular to a method for bionic preparation of organic-inorganic hybrid microcapsules by simulating body fluids and a preparation method thereof, specifically a method for bionics preparation of organic-inorganic hybrid materials by simulating body fluids. Background technique: [0002] Due to its suitable hydrophilicity, controllable mass transfer characteristics and excellent physical and chemical properties, organic-inorganic hybrid microcapsules can be used as a multifunctional material and are widely used in drug embedding, immobilized enzymes and cells, and cosmetics. quality assurance and so on. At present, the preparation methods of organic-inorganic hybrid carriers mainly include: intercalation method, in-situ polymerization method, self-assembly method and sol-gel method, etc. The intercalation method has a simple process, abundant and low-cost raw materials, and because ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/02A61K8/73A61K8/02B01J13/02C12N11/00C07K17/00
Inventor 姜忠义张蕾石家福
Owner TIANJIN UNIV