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Heard-brain benefiting dropping pills and method for preparing same

A technology of benefiting the heart and dropping pills. It is used in pill delivery, pharmaceutical formulations, cardiovascular system diseases, etc., to achieve the effects of increasing specific surface area, dilating coronary arteries, and improving solubility.

Inactive Publication Date: 2010-05-19
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of using natural plant drugs to treat cardiovascular and cerebrovascular diseases, the present invention provides a traditional Chinese medicine Yixinnao dripping pill and its preparation method

Method used

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  • Heard-brain benefiting dropping pills and method for preparing same
  • Heard-brain benefiting dropping pills and method for preparing same
  • Heard-brain benefiting dropping pills and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the formula of Chinese medicine Yixinnao dripping pill: Radix Astragali 15g, Panax notoginseng 6g, Safflower 9g, Gardenia 9g, Borneolum 0.5g The water-soluble solid matrix that the present invention adopts is polyethylene glycol 6000 (PEG-6000 ) and polyethylene glycol 4000 (PEG-4000).

[0031] The preparation method of the present invention is:

[0032] 【Extract preparation】

[0033] a. Grind astragalus, notoginseng, gardenia and safflower into coarse powder, first impregnate with 50% ethanol for 24 hours, then use 12 times the mass of 50% ethanol to percolate, and collect the filtrate at a percolation speed of 5ml / min , the condition of the filtrate is: 60-70°C, -0.08MPa decompression concentration to recover ethanol, concentrated to a thick paste with a relative density of 1.30-1.32 (60-70°C), and the concentrated thick paste at 60-70°C, - Dry under reduced pressure for 8 hours at 0.08Mpa, and pass through a 100-mesh sieve to obtain product A;

[003...

experiment example 1

[0069] Experimental Example 1 Mix the drug powder with the molten matrix (PEG4000 and PEG6000=3:1), drop it into the immiscible condensing agent simethicone, and fix other conditions (the ratio of drug to matrix is ​​1: 2; the dripping temperature is 75°C; the dripping speed is 30d / min), and the dripping is made into pellets.

experiment example 2

[0070] Experimental Example 2 Mix the drug powder with the molten matrix (PEG4000 and PEG6000=2:1), drop it into the immiscible condensing agent simethicone, and fix other conditions (the ratio of drug to matrix is ​​1: 2; the dripping temperature is 75°C; the dripping speed is 30d / min), and the dripping is made into pellets.

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Abstract

The invention relates to a Chinese medicinal preparation, in particular to heard-brain benefiting dropping pills for treating cardiovascular and cerebrovascular diseases and a method for preparing the same. The invention aims to solve the problem of treating cardiovascular and cerebrovascular diseases by natural plant medicaments. The dropping pill is characterized by consisting of the following raw material medicaments in part by weight: 13 to 17 parts of astragalus, 5 to 7 parts of sanchi, 8 to 10 parts of safflower, 8 to 10 parts of cape jasmine fruit and 1 to 5 parts of borneol. In the heard-brain benefiting dropping pills of the invention, the water soluble polyethylene glycol solid dispersion technique is used to disperse effective components of the medicaments on water soluble carriers in a molecular, colloidal, amorphous or ultrathin state, so that the degree of dispersion of the medicaments is improved, the medicament granularity is reduced, and the specific surface area is increased; because the carriers are water soluble, the dissolvability of the medicaments is improved, the dissolution rate is increased, the biological utilization rate is improved, the clinical curing effect is improved, and the aim of quick response is achieved; and thus, the heard-brain benefiting dropping pills are suitable to be used for treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine Yixinnao dripping pill for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a major disease that seriously endangers human health. Its mortality rate has always ranked second, and it has the characteristics of high prevalence, high disability rate, and high mortality rate. In recent years, drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases have made great progress in the development, application and clinical treatment. Damage and other side effects of varying degrees. With the rise of the upsurge of people returning to nature, mining and developing new low-toxicity and high-efficiency drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases from natural plants a...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/20A61P9/10A61K31/045
Inventor 李晓妮张剑宇张晓霞张艳利杨兴鑫
Owner SHANXI MEDICAL UNIV
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