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Method for preparing Ag-carrying bacterial cellulose hydrogel antimicrobial dressing and product thereof

A bacterial cellulose and hydrogel technology, which is applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of complex preparation process route, difficult to scale production, etc., and achieves controllable preparation technology, simple and easy preparation process, Avoid the effects of the use of reducing agents

Active Publication Date: 2012-07-18
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process route is relatively complicated, and it is not easy to produce on a large scale

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) The bacterial cellulose hydrogel membrane was prepared by Acetobacter xylinum, and the separated and purified bacterial cellulose hydrogel membrane was immersed in a 0.01mol / L silver nitrate solution for 5 minutes.

[0034] (2) The bacterial cellulose hydrogel membrane and the silver nitrate solution were moved into an autoclave, and treated at a temperature of 121° C. and a pressure of 0.205 MPa under high temperature and high pressure for 10 minutes.

[0035] (3) Wash the processed composite membrane with twice distilled water, and the washing time is 10 minutes, until silver metal ions no longer appear in the distilled water after washing; the composite membrane after cleaning is partially dehydrated by natural drying, and γ-irradiated to sterilize , that is, a silver-loaded bacterial cellulose hydrogel antibacterial dressing with silver metal nanoparticles attached to the bacterial cellulose three-dimensional porous network structure is obtained. Wherein, the hy...

Embodiment 2

[0037] (1) The bacterial cellulose hydrogel membrane was prepared from Acetobacter acetogenes, and the separated and purified bacterial cellulose hydrogel membrane was immersed in a 0.001mol / L silver nitrate solution for 2 minutes.

[0038] (2) Move the bacterial cellulose hydrogel membrane together with the silver nitrate solution into an autoclave, and treat for 30 minutes at a temperature of 121° C. and a pressure of 0.25 MPa under high temperature and high pressure.

[0039] (3) Wash the treated composite membrane with twice distilled water, and the washing time is 20 minutes, until silver metal ions no longer appear in the distilled water after washing; Bacteria, that is, a silver-loaded bacterial cellulose hydrogel antibacterial dressing with silver metal nanoparticles attached to the bacterial cellulose three-dimensional porous network structure is obtained. Wherein, the hydrogel dressing is composed of 1% bacterial cellulose in mass percentage, 0.01% in mass percentage...

Embodiment 3

[0041] (1) The bacterial cellulose hydrogel membrane was prepared from Bacillus aceti. The separated and purified bacterial cellulose hydrogel membrane was immersed in a 0.1 mol / L silver sulfate solution for 10 min.

[0042] (2) The bacterial cellulose hydrogel membrane and the silver nitrate solution were moved into an autoclave, and treated at a temperature of 125° C. and a pressure of 0.232 MPa under high temperature and high pressure for 5 minutes.

[0043] (3) wash the processed composite membrane with physiological saline, and the washing time is 15 minutes, until silver metal ions no longer appear in the distilled water after washing; the composite membrane after cleaning is dehydrated through vacuum drying, electron beam sterilization After sterilization, the silver-loaded bacterial cellulose hydrogel antibacterial dressing with silver metal nanoparticles attached to the bacterial cellulose three-dimensional porous network structure is obtained. Wherein, the hydrogel d...

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Abstract

The invention discloses a method for preparing an Ag-carrying bacterial cellulose hydrogel antimicrobial dressing and a product thereof. The method comprises the following steps of: soaking a bacterial cellulose hydrogel film in solution of silver metal precursor; then heating the film to be between 121 and 135 DEG C in a high-pressure sterilizing pot, and pressurizing between 0.205 and 0.313MPa;standing bacterial cellulose for 5 to 30min; and then taking the treated bacterial cellulose out for washing, partial dehydration, packaging and sterilization to obtain an Ag-carrying bacterial cellulose hydrogel antimicrobial dressing which is formed by compounding silver metal nano-particles and bacterial cellulose and is attached with 0.01 to 10 weight percent of the silver metal nano-particles in a bacterial cellulose three-dimensional porous network structure. The preparation process of the invention has the advantages of simplicity, easiness, convenient operation, controllable preparation technology, no pollution and low cost; and the prepared nano-particles have the advantages of high purity, small particle size, uniform size and good dispersity. The obtained Ag-carrying bacterial cellulose hydrogel antimicrobial dressing has the characteristics of good antimicrobial property, high water content, good water-retaining property, strong toughness, good air permeability and the like, and can meet the requirements of treating various wounds by a wet method.

Description

technical field [0001] The invention relates to a method for preparing a silver-loaded bacterial cellulose hydrogel antibacterial dressing and a product thereof. The invention belongs to the composite field of metal nanomaterials and biopolymer materials, and specifically relates to a method for preparing silver metal nanoparticle composite bacterial cellulose with bacterial cellulose as a carrier and a product thereof. Background technique [0002] Humans have been using dressings for a long time, but the wound dressings used in the 1960s were all for the purpose of absorbing, removing wound exudate and isolating wounds. With the popularity of "wet therapy", high-tech medical dressings have been paid more and more attention in the medical and health field since the 1970s. Traditional cotton gauze is increasingly being replaced by new medical dressings. In August 2000, the U.S. Food and Drug Administration (FDA) particularly emphasized in the newly promulgated wound medica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42
Inventor 钟春燕李喆陈仕艳王华平王朝生潘磊
Owner DONGHUA UNIV
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